Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Andreas S. Ivessa"'
Autor:
Andreas S. Ivessa, Sukhwinder Singh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Calorie restriction (CR), which is a reduction in calorie intake without malnutrition, usually extends lifespan and improves tissue integrity. This report focuses on the relationship between nuclear genomic instability and dietary-restrictio
Externí odkaz:
https://doaj.org/article/9eb5a63e543d41358f5eaee0ed6f440d
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1747-1754 (2016)
There is substantial evidence that genomic instability increases during aging. Replication pausing (and stalling) at difficult-to-replicate chromosomal sites may induce genomic instability. Interestingly, in aging yeast cells, we observed reduced rep
Externí odkaz:
https://doaj.org/article/2733ad0951e942d3aabaab94c0b28397
Autor:
Michelle D. Tallquist, Shohei Ikeda, Yu Zhang, Shinichi Oka, Wataru Mizushima, Jamie Francisco, Peiyong Zhai, Jae Im Jeong, Andreas S. Ivessa, Dominic P. Del Re
Publikováno v:
JACC: Basic to Translational Science. 5:931-945
Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea51887b6aa1f2819792ee1f62c4444b
https://doi.org/10.1016/j.jacbts.2020.07.009
https://doi.org/10.1016/j.jacbts.2020.07.009
Autor:
Andreas S. Ivessa, Jamie Francisco, Jae Im Jeong, Yu Zhang, Yasuki Nakada, Dominic P. Del Re, Chun-yang Huang, Shinichi Oka, Gopal J. Babu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Fibrosis is a hallmark of heart disease independent of etiology and is thought to contribute to impaired cardiac dysfunction and development of heart failure. However, the underlying mechanisms that regulate the differentiation of fibroblasts to myof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b867e842c374d39e0fc4d7cfd16b36fa
https://doi.org/10.1038/s41598-021-89989-5
https://doi.org/10.1038/s41598-021-89989-5
Publikováno v:
J Mol Cell Cardiol
Coordinated functional balance of negative and positive transcription complexes maintain and accommodate gene expression in hearts during quiescent and hypertrophic conditions, respectively. Negative elongation factor (Nelf) complex has been implicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a102d7dd4059dc24ea2f72a23375a3b
https://europepmc.org/articles/PMC7275912/
https://europepmc.org/articles/PMC7275912/
Autor:
Andreas S. Ivessa
Publikováno v:
Trends in Cancer. 3:387-390
Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes by the mutant alleles. The underlying mechanisms, of why LOH rates increase with age, are not well understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694c2c140c6d6d311186459b8baeb23
https://doi.org/10.1016/j.trecan.2017.04.003
https://doi.org/10.1016/j.trecan.2017.04.003
Autor:
Yasuki Nakada, Peiyong Zhai, Zhi Yang, Michinari Nakamura, Satomi Dohi, Andreas S. Ivessa, Junichi Sadoshima, Maha Abdellatif, Natalija Odanovic
Publikováno v:
Cardiovascular research. 117(11)
Aims A diet with modified components, such as a ketogenic low-carbohydrate (LC) diet, potentially extends longevity and healthspan. However, how a LC diet impacts on cardiac pathology during hemodynamic stress remains elusive. This study evaluated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5df1c5a222816676d955fd343f6e169
https://pubmed.ncbi.nlm.nih.gov/33772583
https://pubmed.ncbi.nlm.nih.gov/33772583
Autor:
Junichi Sadoshima, Chiao Po Hsu, Hong Li, Andreas S. Ivessa, Dominic P. Del Re, Dae-Sik Lim, Daniela Zablocki, Mitsuaki Isobe, Yasuhiro Maejima, Peiyong Zhai, Sebastiano Sciarretta, Tong Liu, Shiori Kyoi
Publikováno v:
Nature medicine
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy. Stress-induced activation of Mst1 in cardiomyocytes promoted accumulation of p62 and aggresome formation, accompan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d422ae87098bdf59da24fd8258465f
https://doi.org/10.1038/nm.3322
https://doi.org/10.1038/nm.3322
Publikováno v:
Aging Cell. 10:438-447
Summary Regulator of G-protein signaling (RGS) proteins contribute to G-protein signaling pathways as activators or repressors with GTPase-activating protein (GAP) activity. To characterize whether regulation of RGS proteins influences longevity in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153bf95b2e7bbbbc9f787d5699589c6e
https://doi.org/10.1111/j.1474-9726.2011.00678.x
https://doi.org/10.1111/j.1474-9726.2011.00678.x
Autor:
Andreas S. Ivessa, Xin Cheng
Publikováno v:
European Journal of Cell Biology. 89:742-747
Previously we demonstrated that the mitochondrial form of the yeast Pif1p DNA helicase, which we found to be attached to mitochondrial DNA (mtDNA), is required for the maintenance of mtDNA under genotoxic stress conditions. Here, we demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978c1a929bd9f73916fbeeaa7cc7adc
https://doi.org/10.1016/j.ejcb.2010.06.008
https://doi.org/10.1016/j.ejcb.2010.06.008