Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Andreas Reinisch"'
Autor:
Laura Scholz, MD, Florian Posch, MD, PhD, Eduard Schulz, MD, PhD, Max Gornicec, MD, Albert Wölfler, MD, Alexander C. Reisinger, MD, PhD, Andreas Reinisch, MD, PhD, Philipp Eller, MD, Florian Eisner, MD, Philipp Kreuzer, MD, Martin Stradner, MD, Alexander R. Rosenkranz, MD, Florian Krammer, PhD, Gernot Schilcher, MD, Robert Krause, MD, Stefan Hatzl, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 2, p e1046 (2024)
OBJECTIVES:. Secondary hemophagocytic lymphohistiocytosis (sHLH) is a cytokine-driven inflammatory syndrome that is associated with substantial morbidity and mortality and frequently leads to ICU admission. Overall survival in adults with sHLH remain
Externí odkaz:
https://doaj.org/article/9d4850746bd04822b4d328e0793b3d35
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 599 (2024)
Acute myeloid leukemia (AML) is an aggressive malignant disease with a high relapse rate due to the persistence of chemoresistant cells. To some extent, these residual cells can be traced by sensitive flow cytometry and molecular methods resulting in
Externí odkaz:
https://doaj.org/article/d553fa8ee5864a048d2f1a9af4c65440
Autor:
Amy C. Fan, Yusuke Nakauchi, Lawrence Bai, Armon Azizi, Kevin A. Nuno, Feifei Zhao, Thomas Köhnke, Daiki Karigane, David Cruz-Hernandez, Andreas Reinisch, Purvesh Khatri, Ravindra Majeti
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Disease-initiating mutations in the transcription factor RUNX1 occur as germline and somatic events that cause leukemias with particularly poor prognosis. However, the role of RUNX1 in leukemogenesis is not fully understood, and effective therapies f
Externí odkaz:
https://doaj.org/article/9d67e910a2aa4c2186e242f58f9edee6
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Langerhans cell histiocytosis (LCH) is a rare and clinically heterogeneous hematological disease characterized by the accumulation of mononuclear phagocytes in various tissues and organs. LCH is often characterized by activating mutations of the mito
Externí odkaz:
https://doaj.org/article/788cb49423fc40b882dc15d0b474e546
Publikováno v:
Bio-Protocol, Vol 13, Iss 2 (2023)
Primary hematopoietic stem and progenitor cell (HSPC)-derived megakaryocytes are a valuable tool for translational research interrogating disease pathogenesis and developing new therapeutic avenues for patients with hematologic disorders including my
Externí odkaz:
https://doaj.org/article/6765bb370d5e4c2fa571f68dd4657f9d
Autor:
Michael A. Koldobskiy, Jordi Abante, Garrett Jenkinson, Elisabet Pujadas, Ashley Tetens, Feifei Zhao, Rakel Tryggvadottir, Adrian Idrizi, Andreas Reinisch, Ravindra Majeti, John Goutsias, Andrew P. Feinberg
Publikováno v:
Epigenetics, Vol 15, Iss 8, Pp 841-858 (2020)
Translocations of the KMT2A (MLL) gene define a biologically distinct and clinically aggressive subtype of acute myeloid leukaemia (AML), marked by a characteristic gene expression profile and few cooperating mutations. Although dysregulation of the
Externí odkaz:
https://doaj.org/article/492a9c76f8d946b29e69b4fde8834c85
Autor:
Shruti Daga, Angelika Rosenberger, Franz Quehenberger, Nina Krisper, Barbara Prietl, Andreas Reinisch, Armin Zebisch, Heinz Sill, Albert Wölfler
Publikováno v:
Cancer Medicine, Vol 8, Iss 4, Pp 1771-1778 (2019)
Abstract Acute myeloid leukemia (AML) is driven by a minor fraction of leukemic stem cells (LSCs) whose persistence is considered being the primary cause of disease relapse. A detailed characterization of the surface immunophenotype of LSCs to discri
Externí odkaz:
https://doaj.org/article/04d90a6c94de47319cc3b03fe10b2578
Autor:
Subarna Sinha, Daniel Thomas, Steven Chan, Yang Gao, Diede Brunen, Damoun Torabi, Andreas Reinisch, David Hernandez, Andy Chan, Erinn B. Rankin, Rene Bernards, Ravindra Majeti, David L. Dill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
There are no robust methods for systematically identifying mutation-specific synthetic lethal (SL) partners in cancer. Here, the authors develop a computational algorithm that uses pan-cancer data to detect mutation-andcancer-specific SL partners and
Externí odkaz:
https://doaj.org/article/e49e620b8adf451f9e5a7aa02173d0b8
Autor:
Rasmus O Bak, Daniel P Dever, Andreas Reinisch, David Cruz Hernandez, Ravindra Majeti, Matthew H Porteus
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/d4c2005f6d104a00964040de1f7520df
Autor:
Rasmus O Bak, Daniel P Dever, Andreas Reinisch, David Cruz Hernandez, Ravindra Majeti, Matthew H Porteus
Publikováno v:
eLife, Vol 6 (2017)
Precise and efficient manipulation of genes is crucial for understanding the molecular mechanisms that govern human hematopoiesis and for developing novel therapies for diseases of the blood and immune system. Current methods do not enable precise en
Externí odkaz:
https://doaj.org/article/5e393cd711a6436783665d4d668bcec8