The human platelet antigen-1b (Pro33) variant of αIIbβ3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state

Autor: Andreas R. P. Beck, Rüdiger E. Scharf, Volker R. Stoldt, Holger Gohlke, Joana Pereira, Giulia Pagani

Publikováno v: Journal of Biological Chemistry. 293:4830-4844

Integrins are heterodimeric cell-adhesion receptors comprising α and β subunits that transmit signals allosterically in both directions across the membrane by binding to intra- and extracellular components. The human platelet antigen-1 (HPA-1) poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57c4d53f8f8321fc2d37f1958271c3a7
https://doi.org/10.1074/jbc.ra118.002149

Involvement of p130 Cas and p105 HEF1 , a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells

Autor: Andreas R. P. Beck, Anne Astier, Hisamaru Hirai, Erica A. Golemis, Serge Manié, Arnold S. Freedman, James D. Griffin, Brian J. Druker, Nilou Haghayeghi, Martin Sattler, Tim Canty, Susan F. Law, Ravi Salgia, Hava Avraham

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1997, 272 (7), pp.4230-4236. ⟨10.1074/jbc.272.7.4230⟩

The Crk-associated substrate p130(Cas) (Cas) and the recently described human enhancer of filamentation 1 (HEF1) are two proteins with similar structure (64% amino acid homology), which are thought to act as "docking" molecules in intracellular signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512ed1125ca980934613b8a25ea5b1d0
https://hal.archives-ouvertes.fr/hal-02322550