Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Andreas R Pfenning"'
Autor:
Alyssa J Lawler, Easwaran Ramamurthy, Ashley R Brown, Naomi Shin, Yeonju Kim, Noelle Toong, Irene M Kaplow, Morgan Wirthlin, Xiaoyu Zhang, BaDoi N Phan, Grant A Fox, Kirsten Wade, Jing He, Bilge Esin Ozturk, Leah C Byrne, William R Stauffer, Kenneth N Fish, Andreas R Pfenning
Publikováno v:
eLife, Vol 11 (2022)
Recent discoveries of extreme cellular diversity in the brain warrant rapid development of technologies to access specific cell populations within heterogeneous tissue. Available approaches for engineering-targeted technologies for new neuron subtype
Externí odkaz:
https://doaj.org/article/95df1d9dbb294e8484fc20dc51bd5aec
Autor:
Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Luis Felipe L Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne
Publikováno v:
eLife, Vol 10 (2021)
Background: Adeno-associated virus (AAV)-mediated gene therapies are rapidly advancing to the clinic, and AAV engineering has resulted in vectors with increased ability to deliver therapeutic genes. Although the choice of vector is critical, quantita
Externí odkaz:
https://doaj.org/article/2f839da7c7b643a2acc12975971ae2e2
Autor:
BaDoi N. Phan, Madelyn H. Ray, Xiangning Xue, Chen Fu, Robert J. Fenster, Stephen J. Kohut, Jack Bergman, Suzanne N. Haber, Kenneth M. McCullough, Madeline K. Fish, Jill R. Glausier, Qiao Su, Allison E. Tipton, David A. Lewis, Zachary Freyberg, George C. Tseng, Shelley J. Russek, Yuriy Alekseyev, Kerry J. Ressler, Marianne L. Seney, Andreas R. Pfenning, Ryan W. Logan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract In brain, the striatum is a heterogenous region involved in reward and goal-directed behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use disorder (OUD). Striatal subregions are divided based on neuroanato
Externí odkaz:
https://doaj.org/article/82f5489316cf4dc69335f0d491c9b09c
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10870 (2010)
Calcium-Response Factor (CaRF) was first identified as a transcription factor based on its affinity for a neuronal-selective calcium-response element (CaRE1) in the gene encoding Brain-Derived Neurotrophic Factor (BDNF). However, because CaRF shares
Externí odkaz:
https://doaj.org/article/66ee6d24791b449f85ef76a649c4e237
Autor:
Irene M. Kaplow, Daniel E. Schäffer, Morgan E. Wirthlin, Alyssa J. Lawler, Ashley R. Brown, Michael Kleyman, Andreas R. Pfenning
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-23 (2022)
Abstract Background Evolutionary conservation is an invaluable tool for inferring functional significance in the genome, including regions that are crucial across many species and those that have undergone convergent evolution. Computational methods
Externí odkaz:
https://doaj.org/article/7743500a21774d7b96b13f84255422c2
Autor:
Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A. Bennett, Li-Huei Tsai, Andreas R. Pfenning
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymo
Externí odkaz:
https://doaj.org/article/ceb332e45eeb48778b5b9d9ca1cfaaef
Autor:
BaDoi N. Phan, Madelyn H. Ray, Xiangning Xue, Robert J. Fenster, Stephen J. Kohut, Jack Bergman, Suzanne N. Haber, Kenneth M. McCullough, Madeline K. Fish, Jill R. Glausier, Qiao Su, Allison E. Tipton, David A. Lewis, Zachary Freyberg, George C. Tseng, Shelley J. Russek, Yuriy Alekseyev, Kerry J. Ressler, Marianne L. Seney, Andreas R. Pfenning, Ryan W. Logan
The striatum in the brain is involved in various behavioral functions, including reward, and disease processes, such as opioid use disorder (OUD). Further understanding of the role of striatal subregions in reward behaviors and their potential associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf90a0c33219c0801ee6ce03b721202
https://doi.org/10.1101/2023.05.17.541145
https://doi.org/10.1101/2023.05.17.541145
Autor:
Jenesis Gayden, Stephanie Puig, Chaitanya Srinivasan, Silas A. Buck, Mackenzie C. Gamble, Jill R. Glausier, Hugo A. Tejeda, Yan Dong, Andreas R. Pfenning, Ryan W. Logan, Zachary Freyberg
Publikováno v:
bioRxiv
Striatal dopamine (DA) neurotransmission is critical for an array of reward-related behaviors and goal-directed motor control. In rodents, 95% of striatal neurons are GABAergic medium spiny neurons (MSNs) that have been traditionally segregated into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21db480c08023acc55d780aaaf7f9273
https://europepmc.org/articles/PMC10187292/
https://europepmc.org/articles/PMC10187292/
Autor:
Noelle Toong, Teresa A. Spix, Irene M. Kaplow, Yazel Goksen, Andreas R. Pfenning, Brian R. Isett, Shruti Nanivadekar, Aryn H. Gittis
Publikováno v:
Science. 374:201-206
Symptoms of neurological diseases emerge through the dysfunction of neural circuits whose diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep brain stimulation (DBS) improves Parkinson’s disease symptoms acu
Autor:
Easwaran Ramamurthy, Snigdha Agarwal, Noelle Toong, Irene M. Kaplow, BaDoi Phan, Andreas R. Pfenning
Alzheimer’s disease (AD) involves aggregation of amyloid β and tau, neuron loss, cognitive decline, and neuroinflammatory responses. Both resident microglia and peripheral immune cells have been associated with the immune component of AD. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc430ab1c42163531e6fb1cacf13626
https://doi.org/10.1101/2022.12.02.518903
https://doi.org/10.1101/2022.12.02.518903