Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andreas Plueckthun"'
Publikováno v:
RSC Chemical Biology.
Late-stage prostate cancer often acquires resistance to conventional chemotherapies and transforms into a hormone-refractory, drug-resistant, and non-curative disease. Developing non-invasive tools to detect the biochemical changes that correlate wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7dab2dd5d0a29ec697a7c8c7d96036
https://doi.org/10.1039/d3cb00010a
https://doi.org/10.1039/d3cb00010a
Autor:
C. Qi, B. Khanppnavar, Andreas Plueckthun, P. Lavriha, Yan Li, Volodymyr M. Korkhov, B. Dreier, Ved Mehta, Ana-Nicoleta Bondar, Jonas V. Schaefer, Michalis Lazaratos, Inayatulla Mohammed, Carmen W. Dessauer
Publikováno v:
Nature Communications, 13 (1)
Adenylyl cyclase 9 (AC9) is a membrane-bound enzyme that converts ATP into cAMP. The enzyme is weakly activated by forskolin, fully activated by the G protein Gαs subunit and is autoinhibited by the AC9 C-terminus. Although our recent structural stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f408d8d097215e104e5e72d262b5dd
Autor:
Erin A. Stephens, T. Ye, Morgan B. Ludwicki, Bunyarit Meksiriporn, Mingji Li, K. J. Forsythe, C. Monticello, Andreas Plueckthun, Matthew P. DeLisa, Lutz Kummer
Ubiquibodies (uAbs) are a customizable proteome editing technology that utilizes E3 ubiquitin ligases genetically fused to synthetic binding proteins to steer otherwise stable proteins of interest (POIs) to the proteasome for degradation. The ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f4466137d09b4151d3e69214ae8619
https://doi.org/10.1101/2021.04.16.440242
https://doi.org/10.1101/2021.04.16.440242
Autor:
Andreas Plueckthun
Publikováno v:
Biophysical Journal. 114:12a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e077c54149ae5210a1616f7921ff631
https://doi.org/10.1016/j.bpj.2017.11.109
https://doi.org/10.1016/j.bpj.2017.11.109
Autor:
Christiane Ganter, Andreas Plueckthun
Publikováno v:
ResearcherID
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from chicken was expressed in and purified from Escherichia coli. To investigate the physical basis of possible protein stabilization strategies, the effect of substitutions of glycine residues by alan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4d062ba8a7a75b7369a3c5be79e64c
https://doi.org/10.1021/bi00492a013
https://doi.org/10.1021/bi00492a013
Autor:
Andreas Plueckthun
Publikováno v:
Biophysical Journal. 108:43a
G protein coupled receptors (GPCRs) have enormous pharmacological relevance but our understanding of GPCR architecture and signaling mechanism has remained limited, as have the design features of agonists and antagonists. Low expression levels, poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b45d90cc727b85800a3042470b0bde7
https://doi.org/10.1016/j.bpj.2014.11.263
https://doi.org/10.1016/j.bpj.2014.11.263
Autor:
Celestino Padeste, Hans-Joachim Guentherodt, Robert Ros, Andreas Plueckthun, Dario Anselmetti, Falk Schwesinger, Louis Tiefenauer
Publikováno v:
Scanning and Force Microscopies for Biomedical Applications.
The identification of specific binding molecules is of increasing interest in the context of drug development based on combinatorial libraries. Scanning Probe Microscopy (SPM) is the method of choice to image and probe individual biomolecules on a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27fb19986caf8067d4ecf3f4de20672a
https://doi.org/10.1117/12.350621
https://doi.org/10.1117/12.350621
Autor:
Edward A. Dennis, Andreas Plueckthun
Publikováno v:
The Journal of Physical Chemistry. 85:678-683
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8a74a90ec693bb6fbc2e708d626bb56
https://doi.org/10.1021/j150606a013
https://doi.org/10.1021/j150606a013