Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andreas Perlegas"'
Autor:
Nadeem Wajih, Swati Basu, Anuj Jailwala, Hee Won Kim, David Ostrowski, Andreas Perlegas, Crystal A. Bolden, Nancy L. Buechler, Mark T. Gladwin, David L. Caudell, Elaheh Rahbar, Martha A. Alexander-Miller, Vidula Vachharajani, Daniel B. Kim-Shapiro
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 1026-1039 (2017)
Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in he
Externí odkaz:
https://doaj.org/article/6cbd35867bd04e4cafdee1f7691998b9
Autor:
Jiqing Zhu, Nadeem Wajih, Daniel B. Kim-Shapiro, Andreas Perlegas, Elmira Alipour, Fernando Rigal, David L. Caudell
Publikováno v:
Nitric Oxide
Nitric oxide, NO, has been explored as a therapeutic agent to treat thrombosis. In particular, NO has potential in treating mechanical device-associated thrombosis due to its ability to reduce platelet activation and due to the central role of platel
Autor:
Swati Basu, Martin Guthold, Elaheh Rahbar, Daniel B. Kim-Shapiro, Robert M. Mayberry, Elisabeth Rebholz, Andreas Perlegas, Kelli N Simms
Publikováno v:
Ann Biomed Eng
OBJECTIVE: Red blood cell (RBC) hemolysis is one of the most common storage lesions in packed RBCs (pRBC). Older units of pRBCs, especially those >21 days old, have increasing levels of hemolysis leading to increased oxidative stress and premature pl
Autor:
Daniel B. Kim-Shapiro, Kamille A. West, Mark T. Gladwin, Swati Basu, Harvey G. Klein, Steven B. Solomon, Irene Cortés-Puch, Dong Wang, Kevin P. Blaine, Junfeng Sun, Jing Feng, Charles Natanson, Andreas Perlegas
Publikováno v:
Transfusion. 59:347-358
Background Storage temperature is a critical factor for maintaining red-blood cell (RBC) viability, especially during prolonged cold storage. The target range of 1 to 6°C was established decades ago and may no longer be optimal for current blood-ban
Autor:
Daniel B. Kim-Shapiro, Mark T. Gladwin, Shekina Gonzalez-Ferrer, David O. Osei-Hwedieh, Samuel L. Brashears, Hernán F. Peñaloza, Tolani F. Olonisakin, Michael A. Bachman, Yuting Xiong, Claudette M. St. Croix, Valerian E. Kagan, Tomeka Suber, Prabir Ray, Andreas Perlegas, Zeyu Xiong, Janet S. Lee, Yulia Y. Tyurina, Eldad A. Hod, Jesús Tejero, Wendy M. Mars, Rick van der Geest, Anuradha Ray, Rama K. Mallampalli, Daria Van Tyne, Matthew R. Rosengart
Publikováno v:
J Clin Invest
Macrophages are main effectors of heme metabolism, increasing transiently in the liver during heightened disposal of damaged or senescent red blood cells (sRBC). Macrophages are also essential in defense against microbial threats, but pathologic stat
Autor:
Kenneth E. Remy, Swati Basu, Charles Natanson, Andreas Perlegas, Junfeng Sun, Juan J Lertora, Steven B. Solomon, Irene Cortés-Puch, Thomas F. Risoleo, Jing Feng, Julia Katz, Xiaohua Liu, Daniel B. Kim-Shapiro, Harvey G. Klein
Publikováno v:
Transfusion, vol 59, iss 12
Transfusion
Transfusion
Background During sepsis, higher plasma cell-free hemoglobin (CFH) levels portend worse outcomes. In sepsis models, plasma proteins that bind CFH improve survival. In our canine antibiotic-treated Staphylococcus aureus pneumonia model, with and witho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1482cde1f932e50b26607475ddb428a
https://escholarship.org/uc/item/9bg3d12h
https://escholarship.org/uc/item/9bg3d12h
Autor:
David L. Caudell, Nancy L. Buechler, Anuj Jailwala, Mark T. Gladwin, Vidula Vachharajani, Hee Won Kim, Daniel B. Kim-Shapiro, Andreas Perlegas, Martha A. Alexander-Miller, Elaheh Rahbar, Nadeem Wajih, Swati Basu, Crystal Bolden, David Ostrowski
Publikováno v:
Redox Biology, Vol 12, Iss, Pp 1026-1039 (2017)
Redox Biology
Redox Biology
Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in he
Autor:
Harvey G. Klein, Samuel L. Brashears, Daniel B. Kim-Shapiro, Junfeng Sun, Dante A. Suffredini, Jesús Barea‐Mendoza, Irene Cortés-Puch, Wanying Xu, Steven B. Solomon, Charles Natanson, Andreas Perlegas
Publikováno v:
Transfusion. 57:2338-2347
BACKGROUND No studies have been performed comparing intravenous (IV) iron with transfused red blood cells (RBCs) for treating anemia during infection. In a previous report, transfused older RBCs increased free iron release and mortality in infected a
Autor:
Daniel B. Kim-Shapiro, Martin Pettinati, Marcelo A. Martí, Darío A. Estrin, Ritesh R. Sevalkar, Elmira Alipour, Vineel P. Reddy, Swati Basu, Joel N. Glasgow, Jack R. Lancaster, Adrie J. C. Steyn, Andreas Perlegas
Publikováno v:
Free Radical Biology and Medicine. 159:S98
Autor:
Mark T. Gladwin, Juan J Lertora, Roy R. Hantgan, H. Shaw Warren, Kenneth E. Remy, Irene Cortés-Puch, Benjamin M Pockros, Xiaohua Liu, Junfeng Sun, Charles Natanson, Andreas Perlegas, Jing Feng, Harvey G. Klein, Steven B. Solomon, Daniel B. Kim-Shapiro
Publikováno v:
JCI insight. 3(18)
During the last half-century, numerous antiinflammatory agents were tested in dozens of clinical trials and have proven ineffective for treating septic shock. The observation in multiple studies that cell-free hemoglobin (CFH) levels are elevated dur