Differential methylation of linoleic acid pathway genes is associated with PTSD symptoms – a longitudinal study with Burundian soldiers returning from a war zone

Autor: Anselm Crombach, Anja C. Rukundo-Zeller, Vanja Vukojevic, Corina Nandi, Manassé Bambonye, Dominique J.-F. de Quervain, Andreas Papassotiropoulos, Thomas Elbert

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract Soldiers may be exposed to traumatic stress during combat deployment and thus are at risk for developing posttraumatic stress disorder (PTSD). Genetic and epigenetic evidence suggests that PTSD is linked to forming stress-related memories. I

Externí odkaz: https://doaj.org/article/edc7947c785b4470bf0732e2c561b2f9

Virtual reality gaze exposure treatment reduces state anxiety during public speaking in individuals with public speaking anxiety: A randomized controlled trial

Autor: Bernhard Fehlmann, Fabian D Mueller, Nan Wang, Merle K Ibach, Thomas Schlitt, Dorothée Bentz, Anja Zimmer, Andreas Papassotiropoulos, Dominique JF de Quervain

Publikováno v: Journal of Affective Disorders Reports, Vol 14, Iss , Pp 100627- (2023)

Background: Public speaking anxiety (PSA) is a prevalent social anxiety affecting up to 30% of the population. Individuals with PSA often express fear of being evaluated by others and avoid eye contact. Despite this behavioral characteristic, the pot

Externí odkaz: https://doaj.org/article/95fe3f57fca74eccbab38abe85fb3c03

Phosphorylation of MSI-1 is implicated in the regulation of associative memory in Caenorhabditis elegans

Autor: Pavlina Mastrandreas, Csaba Boglari, Andreas Arnold, Fabian Peter, Dominique J.-F. de Quervain, Andreas Papassotiropoulos, Attila Stetak

Publikováno v: PLoS Genetics, Vol 18, Iss 10 (2022)

The Musashi family of RNA-binding proteins controls several biological processes including stem cell maintenance, cell division and neural function. Previously, we demonstrated that the C. elegans Musashi ortholog, msi-1, regulates forgetting via tra

Externí odkaz: https://doaj.org/article/b3b058391920430089b560dae159271e

The genetic architecture of human brainstem structures and their involvement in common brain disorders

Autor: Torbjørn Elvsåshagen, Shahram Bahrami, Dennis van der Meer, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur-Streubel, Alessandro Bertolino, Mona K. Beyer, Giuseppe Blasi, Stefan Borgwardt, Birgitte Boye, Jan Buitelaar, Erlend Bøen, Elisabeth Gulowsen Celius, Simon Cervenka, Annette Conzelmann, David Coynel, Pasquale Di Carlo, Srdjan Djurovic, Sarah Eisenacher, Thomas Espeseth, Helena Fatouros-Bergman, Lena Flyckt, Barbara Franke, Oleksandr Frei, Barbara Gelao, Hanne Flinstad Harbo, Catharina A. Hartman, Asta Håberg, Dirk Heslenfeld, Pieter J. Hoekstra, Einar A. Høgestøl, Rune Jonassen, Erik G. Jönsson, Karolinska Schizophrenia Project (KaSP) consortium, Peter Kirsch, Iwona Kłoszewska, Trine Vik Lagerberg, Nils Inge Landrø, Stephanie Le Hellard, Klaus-Peter Lesch, Luigi A. Maglanoc, Ulrik F. Malt, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Torgeir Moberget, Jan Egil Nordvik, Lars Nyberg, Kevin S. O’ Connell, Jaap Oosterlaan, Marco Papalino, Andreas Papassotiropoulos, Paul Pauli, Giulio Pergola, Karin Persson, Dominique de Quervain, Andreas Reif, Jaroslav Rokicki, Daan van Rooij, Alexey A. Shadrin, André Schmidt, Emanuel Schwarz, Geir Selbæk, Hilkka Soininen, Piotr Sowa, Vidar M. Steen, Magda Tsolaki, Bruno Vellas, Lei Wang, Eric Westman, Georg C. Ziegler, Mathias Zink, Ole A. Andreassen, Lars T. Westlye, Tobias Kaufmann

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that i

Externí odkaz: https://doaj.org/article/bb60787933434b12ab5b236140b403a3

Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect

Autor: Anastasia P. Grigorenko, Maria S. Protasova, Alexandra A. Lisenkova, Denis A. Reshetov, Tatiana V. Andreeva, Gilberto De Lima Garcias, Maria Da Graça Martino Roth, Andreas Papassotiropoulos, Evgeny I. Rogaev

Publikováno v: Cells, Vol 11, Iss 3, p 400 (2022)

Bipedalism, speech, and intellect are the most prominent traits that emerged in the evolution of Homo sapiens. Here, we describe a novel genetic cause of an “involution” phenotype in four patients, who are characterized by quadrupedal locomotion,

Externí odkaz: https://doaj.org/article/2cb7439ceeb144b198316666e33a6a09