Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Andreas Neueder"'
Autor:
Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Björn von Einem, Gillian P. Bates, G. Bernhard Landwehrmeyer, Andreas Neueder
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-11 (2024)
Abstract Background The disease-causing mutation in Huntington disease (HD) is a CAG trinucleotide expansion in the huntingtin (HTT) gene. The mutated CAG tract results in the production of a small RNA, HTT1a, coding for only exon 1 of HTT. HTT1a is
Externí odkaz:
https://doaj.org/article/9ec4c65459834bfbab4da67068402bb0
Autor:
Andreas Neueder, Philipp Nitzschner, Ronja Wagner, Julia Hummel, Franziska Hoschek, Maximilian Wagner, Alshaimaa Abdelmoez, Björn vonEinem, G. Bernhard Landwehrmeyer, Sarah J. Tabrizi, Michael Orth
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 1, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/19f6feb2cffc4452b1934535095a3080
Autor:
Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Björn von Einem, Gillian P. Bates, G. Bernhard Landwehrmeyer, Andreas Neueder
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/2d846457660242f48e96f658de611dda
Autor:
Andreas Neueder, Kerstin Kojer, Tanja Hering, Daniel J. Lavery, Jian Chen, Nathalie Birth, Jaqueline Hallitsch, Sonja Trautmann, Jennifer Parker, Michael Flower, Huma Sethi, Salman Haider, Jong-Min Lee, Sarah J. Tabrizi, Michael Orth
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Background A major challenge in neurodegenerative diseases concerns identifying biological disease signatures that track with disease progression or respond to an intervention. Several clinical trials in Huntington disease (HD), an inherited
Externí odkaz:
https://doaj.org/article/91d57965d1a84fddb14c7d745fbb7ca5
Autor:
Aynur Sönmez, Rasem Mustafa, Salome T. Ryll, Francesca Tuorto, Ludivine Wacheul, Donatella Ponti, Christian Litke, Tanja Hering, Kerstin Kojer, Jenniver Koch, Claudia Pitzer, Joachim Kirsch, Andreas Neueder, Grzegorz Kreiner, Denis L. J. Lafontaine, Michael Orth, Birgit Liss, Rosanna Parlato
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract Transcriptional and cellular-stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal-dominant neurodegenerative disorder caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The
Externí odkaz:
https://doaj.org/article/ef5389a9059145348fc5353ee8922ca1
Autor:
Michael A. Mason, Casandra Gomez-Paredes, Kirupa Sathasivam, Andreas Neueder, Aikaterini-Smaragdi Papadopoulou, Gillian P. Bates
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract We have previously shown that the incomplete splicing of exon 1 to exon 2 of the HTT gene results in the production of a small polyadenylated transcript (Httexon1) that encodes the highly pathogenic exon 1 HTT protein. There is evidence to s
Externí odkaz:
https://doaj.org/article/75c2b3b27ebe45d08097db3813c6768f
Autor:
Christina B. Bielmeier, Sabrina I. Schmitt, Nikolai Kleefeldt, Stefaniya K. Boneva, Anja Schlecht, Mario Vallon, Ernst R. Tamm, Jost Hillenkamp, Süleyman Ergün, Andreas Neueder, Barbara M. Braunger
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2626 (2022)
Transforming growth factor β (TGFβ) signaling has manifold functions such as regulation of cell growth, differentiation, migration, and apoptosis. Moreover, there is increasing evidence that it also acts in a neuroprotective manner. We recently sho
Externí odkaz:
https://doaj.org/article/703eb6eb3f2147ef8a1a458ad30f94f2
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.
Externí odkaz:
https://doaj.org/article/bd15556f976d414a8586ab29954b52a8
Autor:
Christina B. Bielmeier, Saskia Roth, Sabrina I. Schmitt, Stefaniya K. Boneva, Anja Schlecht, Mario Vallon, Ernst R. Tamm, Süleyman Ergün, Andreas Neueder, Barbara M. Braunger
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6307 (2021)
Hereditary retinal degenerations like retinitis pigmentosa (RP) are among the leading causes of blindness in younger patients. To enable in vivo investigation of cellular and molecular mechanisms responsible for photoreceptor cell death and to allow
Externí odkaz:
https://doaj.org/article/160ef5e94e2a49c08176d4db1d1fd420
Autor:
Andreas Neueder, Christian Landles, Rhia Ghosh, David Howland, Richard H. Myers, Richard L. M. Faull, Sarah J. Tabrizi, Gillian P. Bates
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract We have previously shown that exon 1 of the huntingtin gene does not always splice to exon 2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein. The level of this read-
Externí odkaz:
https://doaj.org/article/880697bfb72a45d88a4cbeba52640f2d