Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Andreas N Madsen"'
Autor:
Thi Ai Diep, Andreas N Madsen, Sandra Krogh-Hansen, Marwa Al-Shahwani, Laila Al-Sabagh, Birgitte Holst, Harald S Hansen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100365 (2014)
BACKGROUND AND AIMS: Oleoylethanolamide and several other N-acylethanolamines (NAEs), e.g. linoleoylethanolamide and palmitoylethanolamide, have anorectic properties in rats, and prolonged intake of a high-fat diet decreases the levels of the anorect
Externí odkaz:
https://doaj.org/article/8f9e4fd7904f4211b62b1d8bf3f769f6
Autor:
Birgitte Holst, Kenneth L Madsen, Anna M Jansen, Chunyu Jin, Mattias Rickhag, Viktor K Lund, Morten Jensen, Vikram Bhatia, Gunnar Sørensen, Andreas N Madsen, Zhichao Xue, Siri K Møller, David Woldbye, Klaus Qvortrup, Richard Huganir, Dimitrios Stamou, Ole Kjærulff, Ulrik Gether
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001542 (2013)
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and t
Externí odkaz:
https://doaj.org/article/1b1e37beba824678913f7f38cf8eb86b
Autor:
Karl Bacos, Luz Andreone, Kristian Helin, Aditya Sankar, Charlotte Ling, Madhusudhan Bysani, Thomas Mandrup-Poulsen, Marie Balslev Backe, Andreas N. Madsen, Birgitte Holst, Steen Seier Poulsen, Chunyu Jin, Marcelo Javier Perone, Karl Agger
Publikováno v:
Journal of Diabetes Research
Journal of Diabetes Research, Vol 2019 (2019)
Backe, M B, Jin, C, Andreone, L, Sankar, A, Agger, K, Helin, K, Madsen, A N, Poulsen, S S, Bysani, M, Bacos, K, Ling, C, Javier Perone, M, Holst, B & Mandrup-Poulsen, T 2019, ' The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis ', Journal of Diabetes Research, vol. 2019, 5451038 . https://doi.org/10.1155/2019/5451038
Journal of Diabetes Research, Vol 2019 (2019)
Backe, M B, Jin, C, Andreone, L, Sankar, A, Agger, K, Helin, K, Madsen, A N, Poulsen, S S, Bysani, M, Bacos, K, Ling, C, Javier Perone, M, Holst, B & Mandrup-Poulsen, T 2019, ' The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis ', Journal of Diabetes Research, vol. 2019, 5451038 . https://doi.org/10.1155/2019/5451038
Aims. Posttranslational modifications of histones and transcription factors regulate gene expression and are implicated in beta-cell failure and diabetes. We have recently shown that preserving H3K27 and H3K4 methylation using the lysine demethylase
Autor:
Rashmi B. Prasad, Torben Hansen, Patrick C.N. Rensen, Sune Skeldal, Dorthe Maria Vittrup, Karen M. Pedersen, Olof Asplund, Christian Bjerggaard Vaegter, Anette Marianne Prior Gjessing, Andreas N. Madsen, Karen Marie Juul Sørensen, Mads Kjolby, Maarten Rotman, Dovile Januliene, Olav M. Andersen, Guido Hermey, Edwin T. Parlevliet, Birgitte Holst, Arne Moller, Gangadaar Thotakura, Ernst-Martin Füchtbauer, Søren Thirup, Peder Madsen, Niels Wellner, Peter Breining, Arulmani Manavalan
Type II diabetes mellitus (T2DM) has reached endemic levels and comprises a substantial burden to the patient and the society. Along with lifestyle factors, a number of genetic loci predisposing to T2DM have been suggested including SORCS1 that encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbdadf328d061149c37f06c00ea13f49
https://doi.org/10.1101/2020.11.10.376178
https://doi.org/10.1101/2020.11.10.376178
Autor:
Thue W. Schwartz, Maja S. Engelstoft, Andreas N. Madsen, Pascal Timshel, Jeppe P. Ekberg, Maria Hauge
Publikováno v:
Molecular and Cellular Endocrinology. 449:64-73
GPR40 is generally known to signal through Gq. However, in transfected cells, certain synthetic agonists can make the receptor signal also through Gs and cAMP (Hauge et al., 2015). Here we find that, in colonic crypt cultures, the GLP-1 secretion ind
Autor:
Birgitte Holst, Anna-Sofie Husted, Jeppe H. Ekberg, Thue W. Schwartz, Frank Reiman, Line Vildbrad Kristensen, Kristoffer L. Egerod, Fiona M. Gribble, Maja S. Engelstoft, Timothy J. Kowalski, Rasmus M. Sichlau, Harald S. Hansen, Andrew D. Howard, Andreas N. Madsen, Pascal Timshel, Maria Hauge
Publikováno v:
Endocrinology
Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, the relative importance of FFA1 (G Protein-coupled Receptor [GPR] 40), FFA4 (GPR120), and GPR119, which all recognize TG metabolites, ie, long-chain fatty
Autor:
Annette G. Beck-Sickinger, Thue W. Schwartz, Kathrin Bellmann-Sickert, Helen M. Cox, Birgitte Holst, Andreas N. Madsen, V. Thieme, N. Jolly
Publikováno v:
British Journal of Pharmacology. 173:3208-3221
Background and purpose Human pancreatic polypeptide (hPP) is known to suppress appetite and food intake, thereby representing a potential therapeutic approach against obesity and associated metabolic disorders. The aim of this study was to improve hP
Autor:
Lis Hasholt, Birgitte Holst, Olga Rudenko, Andreas N. Madsen, Anne Nørremølle, Louisa J. Skov, Cecilie Springer
Publikováno v:
Journal of Neuroendocrinology. 31
Huntington's disease (HD) is a heritable neurodegenerative disorder, characterised by metabolic disturbances, along with cognitive and psychiatric impairments. Targeting metabolic HD dysfunction via the maintenance of body weight and fat mass and res
Autor:
Louise Aas Holm, Alireza Kashani, Birgitte Holst, Andreas N. Madsen, Georg K. Gerber, Asker Daniel Brejnrod, Timo Kern, Chunyu Jin, Manimozhiyan Arumugam, Torben Hansen, Jens-Christian Holm
Publikováno v:
Kashani, A, Brejnrod, A D, Jin, C, Kern, T, Madsen, A N, Holm, L A, Gerber, G K, Holm, J-C, Hansen, T, Holst, B & Arumugam, M 2019, ' Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob/ob mice ', Animal Microbiome, vol. 1, 11 . https://doi.org/10.1186/s42523-019-0007-1
Animal Microbiome, Vol 1, Iss 1, Pp 1-16 (2019)
Animal Microbiome
Animal Microbiome, Vol 1, Iss 1, Pp 1-16 (2019)
Animal Microbiome
Background Growing evidence supports the role of gut microbiota in obesity and its related disorders including type 2 diabetes. Ob/ob mice, which are hyperphagic due to leptin deficiency, are commonly used models of obesity and were instrumental in s
Autor:
Michel Bouvier, Bianca Plouffe, Stefan Offermanns, Andreas N. Madsen, Thomas M. Frimurer, Birgitte Holst, Michael Lückmann, Louise J. Skov, Bjoørn Sivertsen, Cecilie Hundahl, Franziska Mende, Thi Ai Diep
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(43)
Biased signaling has been suggested as a means of selectively modulating a limited fraction of the signaling pathways for G-protein–coupled receptor family members. Hence, biased ligands may allow modulation of only the desired physiological functi