Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andreas Mantoulidis"'
Autor:
Lukas Junk, Volker M. Schmiedel, Somraj Guha, Katharina Fischel, Peter Greb, Kristin Vill, Violetta Krisilia, Lasse van Geelen, Klaus Rumpel, Parvinder Kaur, Ramya V. Krishnamurthy, Shridhar Narayanan, Radha Krishan Shandil, Mayas Singh, Christiane Kofink, Andreas Mantoulidis, Philipp Biber, Gerhard Gmaschitz, Uli Kazmaier, Anton Meinhart, Julia Leodolter, David Hoi, Sabryna Junker, Francesca Ester Morreale, Tim Clausen, Rainer Kalscheuer, Harald Weinstabl, Guido Boehmelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Antimicrobial resistance is a global health threat that requires the development of new treatment concepts. These should not only overcome existing resistance but be designed to slow down the emergence of new resistance mechanisms. Targeted
Externí odkaz:
https://doaj.org/article/762402cfc91745d09f200167975e5d00
Autor:
Joachim Bröker, Alex G. Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R. Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, Lorenz Herdeis, Tobias Wunberg, Andreas Gollner, Harald Weinstabl, Andreas Mantoulidis, Oliver Krämer, Darryl B. McConnell, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 65:14614-14629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4c212d783bab500794ca19ea0996c93
https://doi.org/10.1021/acs.jmedchem.2c01120
https://doi.org/10.1021/acs.jmedchem.2c01120
Autor:
Dongsung Kim, Lorenz Herdeis, Dorothea Rudolph, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I. Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y. Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kropatsch, Rui Qu, Elisa de Stanchina, Ben Sang, Chuanchuan Li, Darryl B. McConnell, Norbert Kraut, Piro Lito
Publikováno v:
Nature.
KRAS is one of the most commonly mutated proteins in cancer, and efforts to directly inhibit its function have been continuing for decades. The most successful of these has been the development of covalent allele-specific inhibitors that trap KRAS G1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409e1bd71739f2699717b05ba38036b5
https://doi.org/10.1038/s41586-023-06123-3
https://doi.org/10.1038/s41586-023-06123-3
Autor:
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J. Martin, Julian E. Fuchs, Gerd Bader, Andreas Gollner, Bernhard Wolkerstorfer, Catherine Rogers, Esra Balıkçı, Jesse J. Lipp, Nikolai Mischerikow, Sandra Doebel, Thomas Gerstberger, Wolfgang Sommergruber, Kilian V. M. Huber, Jark Böttcher
Publikováno v:
ChemMedChem. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d1b74e691f2507bc3544e1dd6c012e
https://doi.org/10.1002/cmdc.202200686
https://doi.org/10.1002/cmdc.202200686
Autor:
Andreas Mantoulidis, Daniel Gerlach, Matthias Treu, Jörg Rinnenthal, Irene Waizenegger, Heribert Arnhof, Joachim Broeker, Jason Phan, Alex G. Waterson, Stephan W. Fesik, Jesse J. Lipp, Fabio Savarese, Annette Machado, Hengyu Lu, Norbert Kraut, Christian Smethurst, Darryl B. McConnell, Mark Petronczki, Timothy P. Heffernan, Michael Gmachl, Francesca Trapani, Andreas Gollner, Joseph R. Daniele, Joseph R. Marszalek, Dorothea Rudolph, Christopher P. Vellano, Peter Ettmayer, Johannes Popow, Marco H. Hofmann
Publikováno v:
Cancer Research. 81:1271-1271
KRASG12C mutations are predominantly found in non-small cell lung cancer (NSCLC, 13%), in colorectal cancer (CRC, 3%), and with a lower prevalence in pancreatic ductal adenocarcinoma (PDAC, 1%). The amino acid exchange at position 12 from glycine to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbdda807f85664794dd2b07fd2adbbf4
https://doi.org/10.1158/1538-7445.am2021-1271
https://doi.org/10.1158/1538-7445.am2021-1271
Autor:
Andreas Schrenk, Daniela Häring, Silke Fischer, Stefan Kornigg, Alex G. Waterson, Andreas Mantoulidis, Manfred Koegl, Markus Zeeb, Thomas Gerstberger, Mark Pearson, Wolfgang Hela, Andreas Zoephel, Darryl B. McConnell, Michael Gmachl, Bernadette Sharps, Jale Karolyi-Oezguer, Johann Hoffmann, Franziska Moser, Jason Phan, Teresa Gmaschitz, David Covini, Bernhard Wolkerstorfer, Qi Sun, Lyne Lamarre, Gabriella Siszler, Renate Schnitzer, Moriz Mayer, Dirk Kessler, Katharina Schipany, Petr Knesl, Christian Salamon, Peter Greb, Stephen W. Fesik, Andreas Gollner, Yvonne Scherbantin, Silvia Munico-Martinez, Craig M. Goodwin, Roland Kousek, Jörg Rinnenthal, Jiqing Sai, Christoph Peinsipp, Laetitia J. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite decades of research, no approved drugs have been discovered for KRAS. Recently, a pocket occurring on the surface of the active and inactive form of KRAS was found, but, due to its comparatively shallow, polar nature, this pocket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb3a3b7c6eb6eb9f74dfaa7050cde56
https://pubmed.ncbi.nlm.nih.gov/32047043
https://pubmed.ncbi.nlm.nih.gov/32047043
Autor:
Gabriella Siszler, Andreas Bergner, Barbara Müllauer, Andreas Mantoulidis, Laetitia J. Martin, Andreas Gollner, Darryl B. McConnell, Bernhard Wolkerstorfer, Xiao-Ling Cockcroft, Moriz Mayer, Dirk Kessler, Wolfgang Hela, Gerhard Fischer, Roland Kousek
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Natural products have proven to be a rich source of molecular architectures for drugs. Here, an integrated approach to natural product screening is proposed, which uncovered eight new natural product scaffolds for KRAS—the most frequently mutated o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76863501a4fb5d279835adefcd8a8f8
https://pubmed.ncbi.nlm.nih.gov/31231840
https://pubmed.ncbi.nlm.nih.gov/31231840
Autor:
Andreas Gollner, Dirk Kessler, Andreas Mantoulidis, Darryl B. McConnell, Bernhard Wolkerstorfer, Gabriella Siszler, Barbara Müllauer, Andreas Bergner, Roland Kousek, Wolfgang Hela, Laetitia J. Martin, Moriz Mayer, Gerhard Fischer, Xiao-Ling Cockcroft
Publikováno v:
Chemistry – A European Journal. 25:11998-11998
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0442b83d758074e821c739a5fad0548a
https://doi.org/10.1002/chem.201903597
https://doi.org/10.1002/chem.201903597
Publikováno v:
Synlett. 2001:1105-1108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6fd23fa9813da11baf5192f79f40d78
https://doi.org/10.1055/s-2001-15145
https://doi.org/10.1055/s-2001-15145
Publikováno v:
Tetrahedron Letters. 39:8633-8636
An easy access to four out of five naturally occurring epothilones (A-E, 1–5 ) is reported. Key steps are an enantioselective Mukaiyama type aldol reaction, ( E )- and ( Z )-selective olefinations, and a sulfone alkylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba1790d57564f1a0bff565ee60a8951
https://doi.org/10.1016/s0040-4039(98)02026-7
https://doi.org/10.1016/s0040-4039(98)02026-7