Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andreas Mahl"'
Autor:
Keith Jones, Michael K. Pugsley, Helen Booler, Wendy Roosen, Aidan McGuire, Jacques Richard, David Jones, Noel Downes, Ruth A. Roberts, Ankie Schoenmakers, Mark Holbrook, Andreas Rothfuss, Julia Hui, Paul Brown, Marjorie A. Peraza, S.G. Moesgaard, Helen Prior, Sonja Beken, Meghan Flaherty, Leigh Ann Burns-Naas, Ian Kimber, Melissa Chapman, Lolke de Haan, Olaf Doehr, Richard J. Weaver, Paul Brooker, Nichola Gellatly, Brian Burlinson, Elisabeth Mortimer-Cassen, Hilla Kedar, Nancy Bower, Lucinda Weir, Andreas Mahl, Alison Wolfreys, Jennifer Harris, Alli Manninen, David W. Clarke, Warren Casey, Paul Baldrick, Fiona Sewell
Publikováno v:
Regulatory Toxicology and Pharmacology. 113:104624
An international expert working group representing 37 organisations (pharmaceutical/biotechnology companies, contract research organisations, academic institutions and regulatory bodies) collaborated in a data sharing exercise to evaluate the utility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64937b1a362ed5fb5c52709a1d9219f
https://doi.org/10.1016/j.yrtph.2020.104624
https://doi.org/10.1016/j.yrtph.2020.104624
Publikováno v:
Toxicologic pathology. 46(2)
Arteritis/polyarteritis occurs spontaneously in many species used in preclinical toxicology studies. In Göttingen minipigs, arteritis/polyarteritis is an occasionally observed background change. In the minipig, this finding differs in frequency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86baa5d11fb7c25c3e3df3491e0a07a9
https://pubmed.ncbi.nlm.nih.gov/29471777
https://pubmed.ncbi.nlm.nih.gov/29471777
Autor:
Terrilyn A. Richardson, Chi-Hse Teng, Audrey Fischer, Marianne Schwald, William Kluwe, Joerg Andreas Mahl, Robin Alec Fairhurst, Luigi Manenti, Francois Pognan, Armin Wolf, Gerd A. Kullak-Ublick, Mathilde Lienard, Jacqueline Kinyamu-Akunda, Elizabeth Skuba, Salah-Dine Chibout, Andreas Weiss, Kuno Wuersch, Philippe Couttet, Heiko Schadt, Diana Graus Porta, Corinne Emotte
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 163(1)
The FGF19- fibroblast growth factor receptor (FGFR4)-βKlotho (KLB) pathway plays an important role in the regulation of bile acid (BA) homeostasis. Aberrant activation of this pathway has been described in the development and progression of a subset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d746446e070550903c7f77a79f7ce1e
https://pubmed.ncbi.nlm.nih.gov/29432567
https://pubmed.ncbi.nlm.nih.gov/29432567
Autor:
André Cordier, David Ledieu, Francois Pognan, Sarah B. Voytek, J. Andreas Mahl, Page Bouchard, Annabelle Heier, Marc Raccuglia, Salah-Dine Chibout, Maria Papoutsi, Diethilde Theil, Carine Kolly, Andreas Hartmann, Katie Kubek-Luck, Christian Trendelenburg, Natalie M. Claudio, Patrick J. Devine
Publikováno v:
Archives of Toxicology
A high incidence of hemangiosarcoma (HSA) was observed in mice treated for 2 years with siponimod, a sphingosine-1-phosphate receptor 1 (S1P1) functional antagonist, while no such tumors were observed in rats under the same treatment conditions. In 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80cfb9fc5b3106fc9755e4ddeae32e9
https://pubmed.ncbi.nlm.nih.gov/29556671
https://pubmed.ncbi.nlm.nih.gov/29556671
Autor:
Elaine Tritto, Francois Pognan, Li Li, Alessandro Piaia, David Ledieu, Nicolau Beckmann, Armin Wolf, Valerie Dubost, Marianne Uteng, Pierre Moulin, Salah-Dine Chibout, Andreas Mahl
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 155(1)
The aim of this study was to determine the relative safety of four antiviral drugs (telbivudine, tenofovir, adefovir, entecavir) against hepatitis B virus with respect to kidney function and toxicity in male Spraque-Dawley rats. The antiviral drugs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35571dc0e691998e508940355cca645
https://pubmed.ncbi.nlm.nih.gov/27742868
https://pubmed.ncbi.nlm.nih.gov/27742868
Publikováno v:
Toxicologic pathology. 44(3)
Minipigs are increasingly being used as an alternative to dog or monkey in nonclinical safety testing of pharmaceuticals since they share similar anatomical and physiological characteristics to humans. Integrative assessment of pharmacodynamic and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfa742f582e52cf3b7d530136f0d0d8
https://pubmed.ncbi.nlm.nih.gov/26698323
https://pubmed.ncbi.nlm.nih.gov/26698323
Autor:
Daniel J. Holder, Douglas Thudium, Francois Legay, P. F. Verdes, Salah-Dine Chibout, Warren E. Glaab, Sean P. Troth, Frank D. Sistare, Wendy J. Bailey, Andreas Mahl, Frank Staedtler, David Gerhold, Katerina Vlasakova, Michael J Topper, Hong Jin, Frank Dieterle, Daniel Robert Roth, Gerard Maurer, Zoltan Erdos, Spencer Reynolds, Daniel Wahl, Yan Yu, Joseph F. Sina, André Cordier, Tom Forest, Elias Perentes, Holly K Clouse, Thomas R. Skopek, Olivier Grenet, Jacky Vonderscher, Nagaraja Muniappa, Josef S Ozer
Publikováno v:
Nature Biotechnology. 28:486-494
The Predictive Safety Testing Consortium's first regulatory submission to qualify kidney safety biomarkers revealed two deficiencies. To address the need for biomarkers that monitor recovery from agent-induced renal damage, we scored changes in the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be18e7daf842766d51dfd09786e797eb
https://doi.org/10.1038/nbt.1627
https://doi.org/10.1038/nbt.1627
Autor:
Vicente Nogues, Jörg Andreas Mahl, Danielle Roman, Maryelle Kolopp, Mireille Court, Beate Vogel
Publikováno v:
Experimental and Toxicologic Pathology. 57:341-345
In view of more morphological and physiological similarities between human and porcine skin than for other laboratory animal species, the minipig is a preferred model to evaluate the safety profile of dermally applied xenobiotics. Different methods o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46c939f51b131c4bf08d1bcc4063362
https://doi.org/10.1016/j.etp.2006.03.004
https://doi.org/10.1016/j.etp.2006.03.004
Autor:
Daniel Robert Roth, Ursula Junker, Elias Perentes, Danielle Roman, Peter Ulrich, Andreas Mahl
Publikováno v:
Experimental and Toxicologic Pathology. 57:367-371
The evaluation of potential adverse effects of pharmaceuticals on the immune system is part of the standard drug development procedures and needs to be available prior to the start of phase III clinical trials. Although the histopathological assessme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062970ca1554a488a370d35d9e90f3a0
https://doi.org/10.1016/j.etp.2006.03.012
https://doi.org/10.1016/j.etp.2006.03.012
Autor:
Markus Winkler, Marc Vergez, Andreas Mahlke, Mathias Gebauer, Phillip Müller, Christoph Reising, Kilian Bartholomé, Olaf Schäfer-Welsen
Publikováno v:
Energies, Vol 16, Iss 22, p 7463 (2023)
In many energy-related applications, components with high heat loads, such as power electronics, play an important role. Pulsating heat pipes (PHPs) are an effective solution to deal with the increasing heat load of these components. In many real-lif
Externí odkaz:
https://doaj.org/article/b3781316bb9d4c0e99112a895c440a73