Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Andreas M. Voll"'
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity liga
Externí odkaz:
https://doaj.org/article/8747d8ebdc714803b1a832dea9eb333a
Autor:
Martha C. Taubert, Jürgen M. Kolos, Christian Meyners, Thomas M. Geiger, Andreas Bracher, Patrick L. Purder, Tim Heymann, Pablo Wessig, Andreas M. Voll, Nils C. Gassen, Anna Charalampidou, Felix Hausch, Stephanie Merz, Thomas Bajaj
Publikováno v:
Angewandte Chemie. 133:13366-13372
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc7ccf4922205c36b9eb05b01bf872ee
https://doi.org/10.1002/ange.202017352
https://doi.org/10.1002/ange.202017352
Autor:
Gabriele M. König, Alesia A. Tietze, Desireé Kaufmann, Raphael Reher, Daniel Tietze, Felix Hausch, Andreas M. Voll
Publikováno v:
Journal of Chemical Information and Modeling. 59:4361-4373
Specific inhibition of G proteins holds a great pharmacological promise to, e.g., target oncogenic Gq/11 proteins and can be achieved by the two natural products FR900359 (FR) and YM-254890 (YM). Unfortunately, recent rational-design-based approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbfb93f4ec22775df34b89235e69beb
https://doi.org/10.1021/acs.jcim.9b00433
https://doi.org/10.1021/acs.jcim.9b00433
Autor:
Stephanie Merz, Felix Hausch, Andreas M. Voll, Patrick L. Purder, Wisely Oki Sugiarto, Michael Bauder, Tim Heymann, Christian Meyners
Publikováno v:
Journal of medicinal chemistry. 64(6)
The FK506-binding protein 51 (FKBP51) emerged as a key player in several diseases like stress-related disorders, chronic pain, and obesity. Linear analogues of FK506 called SAFit were shown to be highly selective for FKBP51 over its closest homologue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07383e4fa788acd0ddb9b755aae709d
https://pubmed.ncbi.nlm.nih.gov/33666419
https://pubmed.ncbi.nlm.nih.gov/33666419
Autor:
Michael Bauder, Andreas M. Voll, Sabine E. Huber, Christian P. Müller, Felix Hausch, Johannes Kornhuber, Liubov S. Kalinichenko, Loretta König
Publikováno v:
Addiction Biology. 25
There is still no widely effective pharmacotherapy for alcohol addiction available in the clinic. FK506-binding protein 51 (FKBP51) is a negative regulator of the glucocorticoid receptor signaling pathway that regulates the stress-induced glucocortic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b71f7535f54983fdab61d71cb4bfe6
https://doi.org/10.1111/adb.12758
https://doi.org/10.1111/adb.12758