Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis

Autor: Ye Cao, Masaya Araki, Yoshimi Nakagawa, Luisa Deisen, Annemarie Lundsgaard, Josephine M. Kanta, Stephanie Holm, Kornelia Johann, Jens Christian Brings Jacobsen, Markus Jähnert, Annette Schürmann, Bente Kiens, Christoffer Clemmensen, Hitoshi Shimano, Andreas M. Fritzen, Maximilian Kleinert

Publikováno v: Molecular Metabolism, Vol 87, Iss , Pp 101991- (2024)

Objective: Dietary medium-chain fatty acids (MCFAs), characterized by chain lengths of 8–12 carbon atoms, have been proposed to have beneficial effects on glucose and lipid metabolism, yet the underlying mechanisms remain elusive. We hypothesized t

Externí odkaz: https://doaj.org/article/a73423385e39458e84871af2e20ee693

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

Autor: Anders B. Klein, Trine S. Nicolaisen, Niels Ørtenblad, Kasper D. Gejl, Rasmus Jensen, Andreas M. Fritzen, Emil L. Larsen, Kristian Karstoft, Henrik E. Poulsen, Thomas Morville, Ronni E. Sahl, Jørn W. Helge, Jens Lund, Sarah Falk, Mark Lyngbæk, Helga Ellingsgaard, Bente K. Pedersen, Wei Lu, Brian Finan, Sebastian B. Jørgensen, Randy J. Seeley, Maximilian Kleinert, Bente Kiens, Erik A. Richter, Christoffer Clemmensen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food

Externí odkaz: https://doaj.org/article/8f1d9eea4091471ca84ea46086fb7636

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Autor: Janne R. Hingst, Rasmus Kjøbsted, Jesper B. Birk, Nicolas O. Jørgensen, Magnus R. Larsen, Kohei Kido, Jeppe Kjærgaard Larsen, Sasha A.S. Kjeldsen, Joachim Fentz, Christian Frøsig, Stephanie Holm, Andreas M. Fritzen, Tine L. Dohlmann, Steen Larsen, Marc Foretz, Benoit Viollet, Peter Schjerling, Peter Overby, Jens F. Halling, Henriette Pilegaard, Ylva Hellsten, Jørgen F.P. Wojtaszewski

Publikováno v: Molecular Metabolism, Vol 40, Iss , Pp 101028- (2020)

Objective: Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption of AMPK function. Findings based on such model

Externí odkaz: https://doaj.org/article/7b639b94cb3449f3af4191459a29d7c6

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

Autor: Anne-Marie Lundsgaard, Andreas M. Fritzen, Kim A. Sjøberg, Lene S. Myrmel, Lise Madsen, Jørgen F.P. Wojtaszewski, Erik A. Richter, Bente Kiens

Publikováno v: Molecular Metabolism, Vol 6, Iss 1, Pp 22-29 (2017)

Objective: Fibroblast-growth factor 21 (FGF21) is thought to be important in metabolic regulation. Recently, low protein diets have been shown to increase circulating FGF21 levels. However, when energy contribution from dietary protein is lowered, ot

Externí odkaz: https://doaj.org/article/54048959bcbc47c6baddc008c0df70d2

Contributors

Autor: Catherine E.M. Aiken, Azita Amiri, Faith L. Anderson, Arthur Argenson, Anna Arita, Hrayr Attarian, Alison Berner, Vineet Bhandari, Vishwanath Bhat, Angelo Jose Goncalves Bos, Neil A. Bradbury, Meghan L. Bucher, Jan Burns, Ilaria Campesi, Arturo Casadevall, Hossein Chiti, Dorte M. Christiansen, Beth Coad, Dolores Corella, Ellie J. Coromilas, Romina Garcia de leon, Virginia Devi-Chou, Jocelyn Dicent, Mehmet Tevfik Dorak, Gillian Einstein, Harun Fajkovic, Ferric C. Fang, Liana Fattore, Anne Fausto-Sterling, Alireza Fazeli, Dov Feldberg, Roger B. Fillingim, Flavia Franconi, Karen H. Frith, Andreas M. Fritzen, Michika Fukui, Liisa A.M. Galea, Dan Gazit, Zulma Gazit, Donato Gemmati, Josephine Giblin, Marek Glezerman, Kasun Godakumara, Sydney Gram, Antonio Guillamon, Susanne B. Haga, Jessica A. Hennessey, Masakatsu Hihara, William V. Holt, Antonia Hufnagel, Hideki Iwaguro, Tannaz Jamialahmadi, Daphna Joel, Emil Jovanov, Natsuko Kakudo, Bente Kiens, Jin Kyung Kim, Sylvia Kirchengast, Stephanie M. Kochav, Suranga P. Kodithuwakku, L.M. Kok, Peter Koopman, Zoe Krut, Atsuyuki Kuro, Ryosuke Kuroda, Satoshi Kushida, Yunjia Lai, Bonnie H. Lee, Ana Lleo, Anne-Marie Lundsgaard, Adriana C. Maggi, Satoshi Matsushita, Margaret M. McCarthy, Alice Melloni, Maurizio Meloni, Gary W. Miller, Suresh Mishra, Toshihito Mitsui, Hiroshi Mizuno, R.G.H.H. Nelissen, Petr Nickl, Tatsuya Nomura, Sabine Oertelt-Prigione, Gabriela Guimaraes Oliveira-Zumda, Jose M. Ordovas, Negin Parsamanesh, Gadi Pelled, Andrei A. Puiu, M. Natasha Rajah, Doodipala Samba Reddy, Željko Reiner, Amirhossein Sahebkar, Yoshitomo Saita, Ibis Sánchez-Serrano, Reza Sari Motlagh, Ivanka Savic, Manuela Schmidinger, Caleb M. Schmidt, Michael A. Schmidt, Radislav Sedlacek, Angelo Serani, Fidaa Shaib, Shahrokh F. Shariat, Keshav K. Singh, Satoshi Sobajima, Dustin J. Sokolowski, Marla B. Sokolowski, Simón(e) D. Sun, Zhongxin Sun, Jihyun Sung, Linn Amanda Syding, Veena Taneja, Diethard Tautz, Lisa M. Thurston, Siobhan Tierney, Veronica Tisato, Morikuni Tobita, Jessica Tollkuhn, Masanori Tsubosaka, Valter Tucci, Carme Uribe, A. Van Noort, Mikhail Votinov, Reubs J. Walsh, Elaine Y. Wan, Leire Zubiaurre-Elorza

Publikováno v: Principles of Gender-Specific Medicine ISBN: 9780323885348

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecb3833742d2c6524e411d2266f8fcf0
https://doi.org/10.1016/b978-0-323-88534-8.09993-4