Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Andreas Kaerner"'
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32:2261-2273
Using desorption electrospray ionization (DESI) as part of an automated high-throughput system, tandem mass spectra of the compounds in a pharmaceutical library were recorded in the positive mode under standardized conditions. Quality control filteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857f15029fd6e75910049f347e0d57e4
https://doi.org/10.1021/jasms.1c00176
https://doi.org/10.1021/jasms.1c00176
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :1-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eadce5bed7b744bc352c3e8c17fc5456
https://doi.org/10.1002/0471266949.bmc261
https://doi.org/10.1002/0471266949.bmc261
Publikováno v:
The Analyst. 144(16)
We describe a reaction screening system, based on a 96-well array, and scaled to suit use on the individual scientist's bench. The system was built by modifying a desktop 3D printer and fitting it with a glass syringe and microtiter plate. The effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b054dd583c0e4a4bd10bac7973293bce
https://pubmed.ncbi.nlm.nih.gov/31322145
https://pubmed.ncbi.nlm.nih.gov/31322145
Autor:
María Luz de la Puente, Thomas J. Perun, Eric P. Seest, John Burnett, Andreas Kaerner, Matthew D. Belvo, Alfonso Rivera, Craig White, Thomas M. Castle, Cristina Anta, Arancha Sonia Marin, Pilar Lopez
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f48a0ccb95124978b7e9e70307ba5c7
https://doi.org/10.1515/9783110500776-004
https://doi.org/10.1515/9783110500776-004
Autor:
Andreas Kaerner, Patrick J. Jansen, Matthew Clemens, Tim A. Smitka, Steven W. Baertschi, Lindsay Maxwell-Backer, Jerry R. Draper, K. Wayne Taylor
Publikováno v:
Journal of pharmaceutical sciences. 108(9)
Prasugrel hydrochloride is the active ingredient in Effient™, a thienopyridine platelet inhibitor. An extensive study of the degradation chemistry of prasugrel hydrochloride (LY640315 hydrochloride) has been carried out on the drug substance (part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a888408d554366a2f98bbc09fb6964f
https://pubmed.ncbi.nlm.nih.gov/30981754
https://pubmed.ncbi.nlm.nih.gov/30981754
The assessment of degradation in pharmaceutical products involves two aspects of analytical measurement. First, a selective analytical method must be available for accurate assay of the parent drug compound, in order to correctly measure any loss. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd4e4ef548ce29201cd50577f97be32
https://doi.org/10.3109/9781439801802-13
https://doi.org/10.3109/9781439801802-13
Autor:
Allen D. Kline, Edward R. Zartler, Huaping Mo, Tim A. Smitka, Frank Delaglio, Gregory A. Stephenson, Jiangli Yan, Andreas Kaerner, Michael J. Shapiro
Publikováno v:
Journal of the American Chemical Society. 126:5008-5017
Residual dipolar couplings (RDCs), in combination with molecular order matrix calculations, were used to unambiguously determine the complete relative stereochemistry of an organic compound with five stereocenters. Three simple one-dimensional experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b47b0cb37b46c4913cef412711aac49
https://doi.org/10.1021/ja037605q
https://doi.org/10.1021/ja037605q
Autor:
Dallas L. Rabenstein, Andreas Kaerner
Publikováno v:
Biochemistry. 38:5459-5470
alpha-Conotoxin GI is a 13 residue snail toxin peptide cross-linked by Cys2-Cys7 and Cys3-Cys13 disulfide bridges. The formation of the two disulfide bonds by thiol/disulfide exchange with oxidized glutathione (GSSG) has been characterized. To charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d50bc3a8d30e137b557269b545113f2
https://doi.org/10.1021/bi9826658
https://doi.org/10.1021/bi9826658
Autor:
Andreas Kaerner, Dallas L. Rabenstein
Publikováno v:
Magnetic Resonance in Chemistry. 36:601-607
Application of an ω1-band-selective, ω1-homonuclear decoupled ROESY (BASHD-ROESY) experiment to the assignment of 1H NMR spectra of peptides is demonstrated. Band selection in the ω1 dimension is achieved with the double pulsed field gradient spin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d02354025f450ace734ee148a85a69
https://doi.org/10.1002/(sici)1097-458x(199808)36:8<601::aid-omr342>3.0.co
https://doi.org/10.1002/(sici)1097-458x(199808)36:8<601::aid-omr342>3.0.co
Publikováno v:
Analytical Chemistry. 69:4310-4316
An NMR method is described for determining residue-specific acid dissociation constants for peptides which contain more than one residue of the same acidic or basic amino acid. The method is based on using the differences in C alpha H proton chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed0afc775c27140510f68666e660431
https://doi.org/10.1021/ac970675t
https://doi.org/10.1021/ac970675t