Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Andreas Kaczmarczyk"'
Autor:
María Pérez-Burgos, Marco Herfurth, Andreas Kaczmarczyk, Andrea Harms, Katrin Huber, Urs Jenal, Timo Glatter, Lotte Søgaard-Andersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Phenotypic heterogeneity in bacteria can result from stochastic processes or deterministic programs. The deterministic programs often involve the versatile second messenger c-di-GMP, and give rise to daughter cells with different c-di-GMP le
Externí odkaz:
https://doaj.org/article/d9083822274d47c3b805ba313a8961d8
A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution
Autor:
Andreas Kaczmarczyk, Simon van Vliet, Roman Peter Jakob, Raphael Dias Teixeira, Inga Scheidat, Alberto Reinders, Alexander Klotz, Timm Maier, Urs Jenal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Monitoring changes of signaling molecules and metabolites with high temporal resolution is key to understanding dynamic biological systems. Here, we use directed evolution to develop a genetically encoded ratiometric biosensor for c-di-GMP,
Externí odkaz:
https://doaj.org/article/804602f9ff134e97855c8b3b96983e8f
Autor:
Andreas Kaczmarczyk, Antje M. Hempel, Christoph von Arx, Raphael Böhm, Badri N. Dubey, Jutta Nesper, Tilman Schirmer, Sebastian Hiller, Urs Jenal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here the authors show that an increase in c-di-GMP concentration modulates the activity of kinase ShkA and transcript
Externí odkaz:
https://doaj.org/article/a8b0383615d04194986ba09c5f07fc8e
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152519 (2016)
In Alphaproteobacteria, the general stress response (GSR) is controlled by a conserved partner switch composed of the sigma factor σ(EcfG), its anti-sigma factor NepR and the anti-sigma factor antagonist PhyR. Many species possess paralogues of one
Externí odkaz:
https://doaj.org/article/c25c7316414342b4bb8953d862e3b8a5
Publikováno v:
Applied and Environmental Microbiology.
Reverse genetics is a powerful approach to study bacterial physiology and behavior by relying on well-developed genetic tools, such as inducible promoters. For the human pathogen Pseudomonas aeruginosa , well-characterized inducible promoters are sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033b0cbfac456762d2e2230f93a6bb0f
https://doi.org/10.1128/aem.00211-23
https://doi.org/10.1128/aem.00211-23
Autor:
Andreas Kaczmarczyk, Simon van Vliet, Roman Peter Jakob, Alberto Reinders, Alexander Klotz, Timm Maier, Urs Jenal
Cyclic diguanylate (c-di-GMP) is a ubiquitous second messenger that regulates a wide range of biological processes in bacteria, including motility, surface attachment, virulence and persistence. The regulatory networks controlling c-di-GMP are genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75eafdc447170f4251781cab21d8a712
https://doi.org/10.1101/2022.10.18.512705
https://doi.org/10.1101/2022.10.18.512705
Autor:
Vanessa R Povolo, Glen G D’Souza, Andreas Kaczmarczyk, Astrid KM Stubbusch, Urs Jenal, Martin Ackermann
Microbial breakdown of carbon polymers is an essential process in all ecosystems. Carbon polymers generally require extracellular breakdown by secreted exoenzymes. Exoenzymes and breakdown products can be lost through diffusion or flow. This diffusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce39e8d143fef150d6e7026097e8be5b
https://doi.org/10.1101/2022.06.13.495907
https://doi.org/10.1101/2022.06.13.495907
Autor:
Johannes Hartl, Patrick Kiefer, Thomas Vonderach, Julia A. Vorholt, Fabian Meyer, Bodo Hattendorf, Andreas Kaczmarczyk, Maximilian Mittelviefhaus, Urs Jenal
Publikováno v:
Nature Metabolism, 2 (2)
Nature metabolism
Nature metabolism
Cell cycle progression requires the coordination of cell growth, chromosome replication, and division. Consequently, a functional cell cycle must be coupled with metabolism. However, direct measurements of metabolome dynamics remained scarce, in part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edef23aec510184bbe6523d86b9c6768
https://doi.org/10.1038/s42255-019-0166-0
https://doi.org/10.1038/s42255-019-0166-0
Autor:
Antje M. Hempel, Andreas Kaczmarczyk, Sebastian Hiller, Jutta Nesper, Christoph von Arx, Urs Jenal, Tilman Schirmer, Raphael Böhm, Badri N. Dubey
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here we demonstrate that a gradual increase in the concentration of the second messenger c-di-GMP determines precise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5067ac8da89e53d22a57c8a12abcf70b
http://link.springer.com/article/10.1038/s41467-020-14585-6
http://link.springer.com/article/10.1038/s41467-020-14585-6
Autor:
Francesca Mangia, Raphael Böhm, Urs Jenal, Andreas Kaczmarczyk, Ivan Plaza-Menacho, Christoph von Arx, Tilman Schirmer, Badri N. Dubey, Elia Agustoni, Sebastian Hiller
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Expression of bacterial genes in response to various cues is predominantly regulated by 2- or multicomponent systems with autophosphorylation of a histidine kinase (HK), the first component, being controlled by an N-terminal sensor domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550be1838c5e577b93d6d7ed4546e81c
http://europepmc.org/articles/PMC6969517
http://europepmc.org/articles/PMC6969517