Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Andreas Hutloff"'
Autor:
Marta Ferreira-Gomes, Yidan Chen, Pawel Durek, Hector Rincon-Arevalo, Frederik Heinrich, Laura Bauer, Franziska Szelinski, Gabriela Maria Guerra, Ana-Luisa Stefanski, Antonia Niedobitek, Annika Wiedemann, Marina Bondareva, Jacob Ritter, Katrin Lehmann, Sebastian Hardt, Christian Hipfl, Sascha Hein, Eberhard Hildt, Mareen Matz, Henrik E. Mei, Qingyu Cheng, Van Duc Dang, Mario Witkowski, Andreia C. Lino, Andrey Kruglov, Fritz Melchers, Carsten Perka, Eva V. Schrezenmeier, Andreas Hutloff, Andreas Radbruch, Thomas Dörner, Mir-Farzin Mashreghi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we de
Externí odkaz:
https://doaj.org/article/6afb3ecd327947ce81ffe2bed6522ae5
Autor:
Ricardo Santamaría, Javier Cruz-Caballero, Polyxeni Gkontra, Alberto Jiménez-Montiel, Cristina Clemente, Juan A. López, María Villalba-Orero, Jesús Vázquez, Andreas Hutloff, Enrique Lara-Pezzi, Alicia G. Arroyo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Removal of poorly perfused capillaries by pruning contributes to remodeling the microvasculature to optimize oxygen and nutrient delivery. Blood flow drives this process by promoting the intravascular migration of endothelial cells in d
Externí odkaz:
https://doaj.org/article/59b3226bfe404e288216a94b75cf606a
Autor:
Stefanie Gryzik, Yen Hoang, Timo Lischke, Elodie Mohr, Melanie Venzke, Isabelle Kadner, Josephine Poetzsch, Detlef Groth, Andreas Radbruch, Andreas Hutloff, Ria Baumgrass
Publikováno v:
eLife, Vol 9 (2020)
Dysregulated cytokine expression by T cells plays a pivotal role in the pathogenesis of autoimmune diseases. However, the identification of the corresponding pathogenic subpopulations is a challenge, since a distinction between physiological variatio
Externí odkaz:
https://doaj.org/article/b192ba23600248ffb4e36f9abad57946
Autor:
Jana Sarkander, Shintaro Hojyo, Mathias Mursell, Yuzuru Yamasaki, Tsung-Yen Wu, Damon J. Tumes, Kosuke Miyauchi, Cam Loan Tran, Jinfang Zhu, Max Löhning, Andreas Hutloff, Mir-Farzin Mashreghi, Masato Kubo, Andreas Radbruch, Koji Tokoyoda
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
CD4 T cell memory is fundamental for long-lasting immunity and effective secondary responses following infection or vaccination. We have previously found that memory CD4 T cells specific for systemic antigens preferentially reside in the bone marrow
Externí odkaz:
https://doaj.org/article/f7e58968267c4ca28fd3c9813a104a1c
Autor:
Julia Ritzau-Jost, Andreas Hutloff
Publikováno v:
Vaccines, Vol 9, Iss 10, p 1074 (2021)
Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review
Externí odkaz:
https://doaj.org/article/78df6cd50279436a88deec12c02859af
Autor:
Dana Vu Van, Katja C. Beier, Lea-Jean Pietzke, Maysun S. Al Baz, Randi K. Feist, Stephanie Gurka, Eckard Hamelmann, Richard A. Kroczek, Andreas Hutloff
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
In secondary lymphoid organs T follicular helper (Tfh) cells help B cells to develop into memory B and plasma cells. Here, the authors show that inflamed lung becomes a reservoir of activated B cells with a germinal centre phenotype, and T cells that
Externí odkaz:
https://doaj.org/article/745dc794203e438ea935aca0e77d92d9
Autor:
Andreas Hutloff
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T and B cell cooperation normally takes place in secondary lymphoid organs (SLO). However, both cell types are also frequently found in inflamed non-lymphoid tissues. Under certain conditions, these infiltrates develop into ectopic lymphoid structure
Externí odkaz:
https://doaj.org/article/ae2a6d9933a04fceb87ea40902ecb5c8
Autor:
Franziska Fuhrmann, Timo Lischke, Fridolin Gross, Tobias Scheel, Laura Bauer, Khalid Wasim Kalim, Andreas Radbruch, Hanspeter Herzel, Andreas Hutloff, Ria Baumgrass
Publikováno v:
eLife, Vol 5 (2016)
The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen loads are translated into appropriate IL-2 production to ensure adequate responses against
Externí odkaz:
https://doaj.org/article/d310283e1bb24d51a07bff04aff02f3f
Autor:
Ismail Sebina, Kylie R James, Megan S F Soon, Lily G Fogg, Shannon E Best, Fabian de Labastida Rivera, Marcela Montes de Oca, Fiona H Amante, Bryce S Thomas, Lynette Beattie, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth, Paul J Hertzog, Geoffrey R Hill, Andreas Hutloff, Christian R Engwerda, Ashraful Haque
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005999 (2016)
Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many months for naturally-exposed individuals to develop robust humoral immunity. Explanations for this have focused on antig
Externí odkaz:
https://doaj.org/article/a54be06609244dfbb023d5a998aed957
Autor:
Andreas Hutloff, Sebastian Drube, Sylvia Müller, Philine Wegner, Romy Böttcher-Loschinski, Nico Andreas, Thomas Kamradt, Franziska Weber, Matthias Gaestel
Publikováno v:
Immunology
Summary IL‐33 is a member of the IL‐1 family. By binding to its receptor ST2 (IL‐33R) on mast cells, IL‐33 induces the MyD88‐dependent activation of the TAK1‐IKK2 signalling module resulting in activation of the MAP kinases p38, JNK1/2 an