Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Andreas Huge"'
Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
Autor:
Cora S. Thiel, Svantje Tauber, Swantje Christoffel, Andreas Huge, Beatrice A. Lauber, Jennifer Polzer, Katrin Paulsen, Hartwin Lier, Frank Engelmann, Burkhard Schmitz, Andreas Schütte, Christiane Raig, Liliana E. Layer, Oliver Ullrich
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-24 (2018)
Abstract The gravitational force has been constant throughout Earth’s evolutionary history. Since the cell nucleus is subjected to permanent forces induced by Earth’s gravity, we addressed the question, if gene expression homeostasis is constantl
Externí odkaz:
https://doaj.org/article/44e64d0c24c0444c8c368d6412db525b
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9426 (2021)
The mechanisms underlying gravity perception in mammalian cells are unknown. We have recently discovered that the transcriptome of cells in the immune system, which is the most affected system during a spaceflight, responds rapidly and broadly to alt
Externí odkaz:
https://doaj.org/article/339a116c667045f685a5197db5235866
Autor:
Cora S. Thiel, Swantje Hauschild, Andreas Huge, Svantje Tauber, Beatrice A. Lauber, Jennifer Polzer, Katrin Paulsen, Hartwin Lier, Frank Engelmann, Burkhard Schmitz, Andreas Schütte, Liliana E. Layer, Oliver Ullrich
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-22 (2017)
Abstract We investigated the dynamics of immediate and initial gene expression response to different gravitational environments in human Jurkat T lymphocytic cells and compared expression profiles to identify potential gravity-regulated genes and ada
Externí odkaz:
https://doaj.org/article/cb286fb18e6c487984773382255761ca
Autor:
Charlotta Sophie Behrens, Maximilian Kolbe, Julia Freese, Sophia Hanke, Maria Köhne, Andreas Huge, Aya Shibamiya, Arne Hansen, Lucie Carrier, Bärbel Ulmer, Thomas Eschenhagen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:155-156
Autor:
Charlotta Sophie Behrens, Julia Freese, Antonia T.L. Zech, Maria Köhne, Christoph Krisp, Ingke Braren, Malte Loos, Maximilian Kolbe, Andreas Huge, Hartmut Schlüter, Arne Hansen, Lucie Carrier, Bärbel Ulmer, Thomas Eschenhagen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:110
Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
Autor:
Swantje Christoffel, Burkhard Schmitz, Frank Engelmann, Andreas Schütte, Hartwin Lier, Jennifer Polzer, Svantje Tauber, Oliver Ullrich, Cora S. Thiel, Liliana E. Layer, Katrin Paulsen, Beatrice A. Lauber, Andreas Huge, Christiane Raig
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-24 (2018)
Scientific Reports
Scientific Reports
The gravitational force has been constant throughout Earth’s evolutionary history. Since the cell nucleus is subjected to permanent forces induced by Earth’s gravity, we addressed the question, if gene expression homeostasis is constantly shaped
Autor:
Frank Rühle, Anika Witten, Andre Franke, Monika Stoll, Verena Limperger, Andrei Barysenka, Andreas Huge, Mona Riemenschneider, Rolf M. Mesters, Ulrike Nowak-Göttl, Astrid Arning, Anne Krümpel, Christine Heller, Wolfgang Lieb, Milan Hiersche
Publikováno v:
Blood, 129(6), 783-790. The American Society of Hematology
Recent genome-wide association studies (GWAS) have confirmed known risk mutations for venous thromboembolism (VTE) and identified a number of novel susceptibility loci in adults. Here we present a GWAS in 212 nuclear families with pediatric VTE follo
Autor:
Reinhard Voss, Delf-Magnus Kummerfeld, Boris V. Skryabin, Jochen Seggewiss, Chenna R. Galiveti, Andreas Huge, Anna Wolters, Carsten A. Raabe, Juergen Brosius, Timofey S. Rozhdestvensky
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The ac
Autor:
Svantje Tauber, Andreas Huge, Jennifer Polzer, Cora S. Thiel, Frank Engelmann, Andreas Schütte, Hartwin Lier, Swantje Hauschild, Burkhard Schmitz, Beatrice A. Lauber, Oliver Ullrich, Liliana E. Layer, Katrin Paulsen
Publikováno v:
NPJ Microgravity
npj Microgravity, Vol 3, Iss 1, Pp 1-20 (2017)
npj Microgravity, Vol 3, Iss 1, Pp 1-20 (2017)
In the last decades, a plethora of in vitro studies with living human cells contributed a vast amount of knowledge about cellular and molecular effects of microgravity. Previous studies focused mostly on the identification of gravity-responsive genes
Autor:
Frank U. Müller, Anika Witten, Eva Wardelmann, Sabine Hamer, Monika Stoll, Juliane Stein, Andreas Huge, Uwe Völker, Elke Hammer, Matthias D. Seidl, Florentina Pluteanu, Beatrix Scholz
Publikováno v:
Circulation: Arrhythmia and Electrophysiology. 10
Background— Reduced expression of genes regulated by the transcription factors CREB/CREM (cAMP response element-binding protein/modulator) is linked to atrial fibrillation (AF) susceptibility in patients. Cardiomyocyte-directed expression of the in