Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andreas Hagenbuch"'
Autor:
Aubin Michalon, Andreas Hagenbuch, Christian Huy, Evita Varela, Benoit Combaluzier, Thibaud Damy, Ole B. Suhr, Maria J. Saraiva, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Analyzing memory B cell repertoires of the healthy elderly enabled Michalon et al. to develop a recombinant human antibody selective for transthyretin amyloid. This antibody removes cardiac amyloid through recruitment of phagocytic immune cells.
Externí odkaz:
https://doaj.org/article/0bd15e092d1f47498ea907338e89a448
Autor:
Andreas Hagenbuch, Ole B. Suhr, Benoit Combaluzier, Roger M. Nitsch, Thibaud Damy, Aubin Michalon, Christoph Hock, Maria João Saraiva, Christian Huy, Evita Varela, Jan Grimm
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Transthyretin amyloid (ATTR) cardiomyopathy is a debilitating disease leading to heart failure and death. It is characterized by the deposition of extracellular ATTR fibrils in the myocardium. Reducing myocardial ATTR load is a therapeutic goal antic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f1dcdd422a02529a33364908bea395
https://doi.org/10.1038/s41467-021-23274-x
https://doi.org/10.1038/s41467-021-23274-x
Autor:
Andreas Hagenbuch, Benoit Combaluzier, Aubin Michalon, Ole B. Suhr, Jan Grimm, Maria João Saraiva, Evita Varela
Publikováno v:
Orphanet Journal of Rare Diseases
Misfolding and aggregation of transthyretin (TTR) is the basic pathophysiological mechanism of hereditary and wild type TTR amyloid (ATTR) amyloidosis. Polyneuropathy and/or cardiomyopathy with heart failure dominates the clinical presentation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4458dba321a3c060f839dfa48805fd1
https://doi.org/10.1186/1750-1172-10-s1-p39
https://doi.org/10.1186/1750-1172-10-s1-p39