Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Andreas H. Wagner"'
Autor:
Young-Hwa Goo, Janeesh Plakkal Ayyappan, Francis D. Cheeran, Sushant Bangru, Pradip K. Saha, Paula Baar, Sabine Schulz, Todd A. Lydic, Bernhard Spengler, Andreas H. Wagner, Auinash Kalsotra, Vijay K. Yechoor, Antoni Paul
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood. LD-associated hydrolase (LDAH) has a lipase structure and high affinity for LDs of foam cells.
Externí odkaz:
https://doaj.org/article/213b8383686e44778bff5f56edd70410
Autor:
Marie Noormalal, Nesrin Schmiedel, Tarik Bozoglu, Andrea Matzen, Susanne Hille, Dima Ibrahim Basha, Prithviraj Manohar Vijaya Shetty, Anja Wolf, Marcin Zaradzki, Rawa Arif, Thomas Pühler, Georg Lutter, Andreas H. Wagner, Christian Kupatt, Derk Frank, Norbert Frey, Anca Remes, Oliver J. Müller
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101163- (2024)
Rupture or dissection of thoracic aortic aneurysms is still the leading cause of death for patients diagnosed with Marfan syndrome. Inflammation and matrix digestion regulated by matrix metalloproteases (MMPs) play a major role in the pathological re
Externí odkaz:
https://doaj.org/article/49ac9d0be7fc467286fe61422e59094f
Autor:
Anton Klersy, Sören Meyer, Florian Leuschner, Thorsten Kessler, Markus Hecker, Andreas H. Wagner
Publikováno v:
Cells, Vol 12, Iss 15, p 1926 (2023)
Background: Homozygosity for the C allele of the −1T>C single nucleotide polymorphism (SNP) of the CD40 gene (rs1883832) is associated with susceptibility to coronary heart disease (CHD), enhanced CD40 expression, and shedding. The disintegrin meta
Externí odkaz:
https://doaj.org/article/8c6827eb1bc7442182e2060cd976b869
Autor:
Anca Remes, Dima Ibrahim Basha, Thomas Puehler, Christopher Borowski, Susanne Hille, Laura Kummer, Andreas H. Wagner, Markus Hecker, Jasmin Soethoff, Georg Lutter, Derk Frank, Rawa Arif, Norbert Frey, Marcin Zaradzki, Oliver J. Müller
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 83-93 (2021)
Gene therapeutic approaches to aortic diseases require efficient vectors and delivery systems for transduction of endothelial cells (ECs) and smooth muscle cells (SMCs). Here, we developed a novel strategy to efficiently deliver a previously describe
Externí odkaz:
https://doaj.org/article/c5e92ee14b7e406480200f11383c9589
Autor:
Anca Remes, Maximilian Franz, Franziska Mohr, Antje Weber, Kleopatra Rapti, Andreas Jungmann, Matthias Karck, Markus Hecker, Klaus Kallenbach, Oliver J. Müller, Rawa Arif, Andreas H. Wagner
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 246-256 (2019)
Transplant vasculopathy (TV), characterized by obstructive lesions in affected vessels, represents one of the long-term complications of cardiac transplantation. Activation of the transcription factor activator protein-1 (AP-1) is implicated in smoot
Externí odkaz:
https://doaj.org/article/80fc4a64a51e45fba94f75402a0c93c3
Autor:
Laura Kummer, Marcin Zaradzki, Vijith Vijayan, Rawa Arif, Markus A. Weigand, Stephan Immenschuh, Andreas H. Wagner, Jan Larmann
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Graft rejection remains the major obstacle after vascularized solid organ transplantation. Endothelial cells, which form the interface between the transplanted graft and the host’s immunity, are the first target for host immune cells. During acute
Externí odkaz:
https://doaj.org/article/30ef069142d846439d459208dabc6965
Autor:
Cheryl S. Sultan, Andrea Saackel, Antonia Stank, Thomas Fleming, Maria Fedorova, Ralf Hoffmann, Rebecca C. Wade, Markus Hecker, Andreas H. Wagner
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 113-122 (2018)
Aims: High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to diabetic complications partly via increased generation of reactive oxygen species (ROS). This study focused on gl
Externí odkaz:
https://doaj.org/article/5d97dc6cbc174b04860c75183c6511cc
Autor:
Tim Weigand, Benjamin Singler, Thomas Fleming, Peter Nawroth, Karel D. Klika, Christian Thiel, Hans Baelde, Sven F. Garbade, Andreas H. Wagner, Markus Hecker, Benito A. Yard, Albert Amberger, Johannes Zschocke, Claus P. Schmitt, Verena Peters
Publikováno v:
Cellular Physiology and Biochemistry, Vol 46, Iss 2, Pp 713-726 (2018)
Background/Aims: Reactive dicarbonyl compounds, such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and anserine, which have been shown to mitigate diabetic nephropathy, were evaluated in vitro and
Externí odkaz:
https://doaj.org/article/9758b7d51f2b44179855a109b72ae677
Autor:
Rawa Arif, Marcin Zaradzki, Anca Remes, Philipp Seppelt, Reiner Kunze, Hannes Schröder, Simon Schwill, Stephan M. Ensminger, Peter N. Robinson, Matthias Karck, Oliver J. Müller, Markus Hecker, Andreas H. Wagner, Klaus Kallenbach
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 69-79 (2017)
Marfan syndrome is characterized by high expression of matrix metalloproteinases (MMPs) in aortic smooth muscle cells (AoSMCs) associated with medial elastolysis and aortic root aneurysm. We aimed to reduce aortic elastolysis through decrease of MMP
Externí odkaz:
https://doaj.org/article/d149b02da641496bb88b5064360f8425
Autor:
Verena Peters, Claus P. Schmitt, Tim Weigand, Kristina Klingbeil, Christian Thiel, Antje van den Berg, Vittorio Calabrese, Peter Nawroth, Thomas Fleming, Elisabete Forsberg, Andreas H. Wagner, Markus Hecker, Giulio Vistoli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1102-1110 (2017)
In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy. We now characterized the interaction of thiol-containing compounds with CN1 cysteine residue at position 102, which is important for CN1
Externí odkaz:
https://doaj.org/article/20d39db7239247e5b611b91497ee3032