An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

Autor: Yao Meng, Sami Sanlidag, Sacha A. Jensen, Sean A. Burnap, Weston B. Struwe, Andreas H. Larsen, Xinyi Feng, Shruti Mittal, Mark S. P. Sansom, Cecilia Sahlgren, Penny A. Handford

Publikováno v: Science Signaling, 15(755):eabo3507. American Association for the Advancement of Science (AAAS)
Meng, Y, Sanlidag, S, Jensen, S A, Burnap, S A, Struwe, W B, Larsen, A H, Feng, X, Mittal, S, Sansom, M S P, Sahlgren, C & Handford, P A 2022, ' An N-glycan on the C2 domain of JAGGED1 is important for Notch activation ', Science Signaling, vol. 15, no. 755, eabo3507 . https://doi.org/10.1126/scisignal.abo3507

The canonical members of the Jagged/Serrate and Delta families of transmembrane ligands have an extracellular, amino-terminal C2 domain that binds to phospholipids and is required for optimal activation of the Notch receptor. Somatic mutations that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4c9efe42b092cdfc89289531844635
http://www.scopus.com/inward/record.url?scp=85139651605&partnerID=8YFLogxK

Coarse-Grained Simulations Suggest Potential Competing Roles of Phosphoinositides and Amphipathic Helix Structures in Membrane Curvature Sensing of the AP180 N-Terminal Homology Domain

Autor: Alexis Belessiotis-Richards, Andreas H. Larsen, Stuart G. Higgins, Molly M. Stevens, Alfredo Alexander-Katz

Publikováno v: The journal of physical chemistry. B. 126(15)

The generation and sensing of membrane curvature by proteins has become of increasing interest to researchers with multiple mechanisms, from hydrophobic insertion to protein crowding, being identified. However, the role of charged lipids in the membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e179e8bc3cef8e69aa72da2314af47da
https://pubmed.ncbi.nlm.nih.gov/35394774