Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andreas H Ludewig"'
Autor:
Andreas H Ludewig, Clotilde Gimond, Joshua C Judkins, Staci Thornton, Dania C Pulido, Robert J Micikas, Frank Döring, Adam Antebi, Christian Braendle, Frank C Schroeder
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006717 (2017)
Environmental conditions experienced during animal development are thought to have sustained impact on maturation and adult lifespan. Here we show that in the model organism C. elegans developmental rate and adult lifespan depend on larval population
Externí odkaz:
https://doaj.org/article/ae12795da473417daaad597e7fbe2665
Autor:
Wiebke Obermann, Mohammad Farhan Darin Azri, Leonie Konopka, Nina Schmidt, Francesca Magari, Julian Sherman, Liliana M. R. Silva, Carlos Hermosilla, Andreas H. Ludewig, Hicham Houhou, Simone Haeberlein, Mona Yiting Luo, Irina Häcker, Marc F. Schetelig, Christoph G. Grevelding, Frank C. Schroeder, Gilbert Sei Kung Lau, Anja Taubert, Ana Rodriguez, Andreas Heine, Tiong Chia Yeo, Arnold Grünweller, Gaspar Taroncher-Oldenburg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A inhibitors, but their anti-pathogenic potential has not been comprehensively assessed
Externí odkaz:
https://doaj.org/article/8922ae7cbaff49e69d1bb970b63c9468
Autor:
Russell N. Burkhardt, Alexander B. Artyukhin, Erin Z. Aprison, Brian J. Curtis, Bennett W. Fox, Andreas H. Ludewig, Diana Fajardo Palomino, Jintao Luo, Amaresh Chaturbedi, Oishika Panda, Chester J. J. Wrobel, Victor Baumann, Douglas S. Portman, Siu Sylvia Lee, Ilya Ruvinsky, Frank C. Schroeder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Biological sex affects all aspects of animal physiology. Using the model C. elegans, the authors show that metabolomes are highly sex-specific and include a vast space of yet unidentified metabolites that may control development and lifespan.
Externí odkaz:
https://doaj.org/article/ee59faf2849443c2ad2e5ad357aac4f5
Autor:
Wiebke Obermann, Mohammad Farhan Darin Bin Azri, Leonie Konopka, Nina Schmidt, Francesca Magari, Julian Sherman, Liliana M. R. Silva, Carlos Hermosilla, Andreas H. Ludewig, Hicham Houhou, Simone Haeberlein, Mona Yiting Luo, Irina Häcker, Marc F. Schetelig, Christoph G. Grevelding, Frank C. Schroeder, Gilbert Lau, Anja Taubert, Ana Rodriguez, Andreas Heine, Tiong Chia Yeo, Arnold Grünweller, Gaspar Taroncher-Oldenburg
Selective inhibition of eukaryotic initiation factor 4A (eIF4A), an RNA helicase, has been proposed as a strategy to fight pathogens. Plant-derived rocaglates exhibit some of the highest specificities among eIF4A inhibitors. Sensitivity to rocaglates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0259411e9ee8279f545aa48ba1d4e761
https://doi.org/10.1101/2022.09.09.507249
https://doi.org/10.1101/2022.09.09.507249
Autor:
Andreas H. Ludewig, Michael P. O'Donnell, Sarah M Cohen, Bennett W. Fox, Paul W. Sternberg, Pedro R Rodrigues, Brian J Curtis, Jingfang Yu, Chester J J Wrobel, Frank C. Schroeder
Publikováno v:
Journal of the American Chemical Society. 143:14676-14683
The recently discovered modular glucosides (MOGLs) form a large metabolite library derived from combinatorial assembly of moieties from amino acid, neurotransmitter, and lipid metabolism in the model organism C. elegans. Combining CRISPR-Cas9 genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9d318e8a7132a97000154a2ff942a0d
https://doi.org/10.1021/jacs.1c05908
https://doi.org/10.1021/jacs.1c05908
Autor:
Russell N. Burkhardt, Alexander B. Artyukhin, Erin Z. Aprison, Brian J. Curtis, Bennett W. Fox, Andreas H. Ludewig, Amaresh Chaturbedi, Oishika Panda, Chester J. J. Wrobel, Siu S. Lee, Ilya Ruvinsky, Frank C. Schroeder
Recent studies of animal metabolism have revealed large numbers of novel metabolites that are involved in all aspects of organismal biology, but it is unclear to what extent metabolomes differ between sexes. Here, using untargeted comparative metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1220bf154dffce0ce96d402d0e8d13b
https://doi.org/10.1101/2022.08.11.503636
https://doi.org/10.1101/2022.08.11.503636
Autor:
Chester J J, Wrobel, Jingfang, Yu, Pedro R, Rodrigues, Andreas H, Ludewig, Brian J, Curtis, Sarah M, Cohen, Bennett W, Fox, Michael P, O'Donnell, Paul W, Sternberg, Frank C, Schroeder
Publikováno v:
J Am Chem Soc
The recently discovered modular glucosides (MOGLs) form a large metabolite library derived from combinatorial assembly of moieties from amino acid, neurotransmitter, and lipid metabolism in the model organism C. elegans. Combining CRISPR-Cas9 genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b1e8b3071aa9a1dfadde9c16716865e
https://pubmed.ncbi.nlm.nih.gov/34460264
https://pubmed.ncbi.nlm.nih.gov/34460264
Autor:
Oishika Panda, Ilya Ruvinsky, Pooja Gudibanda, Erin Z. Aprison, Pedro R Rodrigues, Andreas H. Ludewig, Russell N. Burkhardt, Ying K. Zhang, Dania C. Pulido, Frank C. Schroeder, Alexander B. Artyukhin
Publikováno v:
Nature chemical biology
Excreted small-molecule signals can bias developmental trajectories and physiology in diverse animal species. However, the chemical identity of these signals remains largely obscure. Here we report identification of an unusual N-acylated glutamine de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bc77bc4c1c9c0358f2469917b3e2c7
https://doi.org/10.1038/s41589-019-0321-7
https://doi.org/10.1038/s41589-019-0321-7
Autor:
Adam Antebi, Frank C. Schroeder, Christian Braendle, Frank Döring, Andreas H. Ludewig, Clotilde Gimond, Robert J. Micikas, Joshua C. Judkins, Dania C. Pulido, Staci Thornton
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006717 (2017)
PLoS Genetics
PLoS Genet
PLoS Genetics
PLoS Genet
Environmental conditions experienced during animal development are thought to have sustained impact on maturation and adult lifespan. Here we show that in the model organism C. elegans developmental rate and adult lifespan depend on larval population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0d46dc5a398980b6bed7a9f8bf2904
http://europepmc.org/articles/PMC5402976?pdf=render
http://europepmc.org/articles/PMC5402976?pdf=render
Autor:
Rabia U. Malik, Parag Mahanti, Donha Park, Frank C. Schroeder, Anna Zimmermann, Andreas H. Ludewig, Donald L. Riddle, Frank Doering, Bennett W. Fox, Axel Bethke, Yevgeniy Izrayelit
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5522-5527
Lifespan in Caenorhabditis elegans , Drosophila , and mice is regulated by conserved signaling networks, including the insulin/insulin-like growth factor 1 (IGF-1) signaling cascade and pathways depending on sirtuins, a family of NAD + -dependent dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbc9d6879b9732228fbca7f96082a48
https://doi.org/10.1073/pnas.1214467110
https://doi.org/10.1073/pnas.1214467110