Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Andreas H Diacon"'
Autor:
Antal Martinecz, Martin J Boeree, Andreas H Diacon, Rodney Dawson, Colin Hemez, Rob E Aarnoutse, Pia Abel Zur Wiesch
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1011000 (2023)
BackgroundAntibiotic treatments are often associated with a late slowdown in bacterial killing. This separates the killing of bacteria into at least two distinct phases: a quick phase followed by a slower phase, the latter of which is linked to treat
Externí odkaz:
https://doaj.org/article/744d2eb58e5f4f758753e7eb9536c66a
Autor:
Robert S Wallis, Rodney Dawson, Sven O Friedrich, Amour Venter, Darcy Paige, Tong Zhu, Annette Silvia, Jason Gobey, Craig Ellery, Yao Zhang, Kathleen Eisenach, Paul Miller, Andreas H Diacon
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94462 (2014)
Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations conferring resistance to standard TB
Externí odkaz:
https://doaj.org/article/1d2f4c6c83044d40877fbbf4225b55e9
Autor:
Aksana Jones, Jay Saini, Belinda Kriel, Laura E. Via, Yin Cai, Devon Allies, Debra Hanna, David Hermann, Andre G. Loxton, Gerhard Walzl, Andreas H. Diacon, Klaus Romero, Ryo Higashiyama, Yongge Liu, Alexander Berg
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-18 (2022)
Abstract Background Despite the high global disease burden of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb) infection, novel treatments remain an urgent medical need. Development efforts continue to be hampered by the reli
Externí odkaz:
https://doaj.org/article/1c33dd8c2a7d407eb03ee7e006988320
Autor:
Jan-Willem C. Alffenaar, Jurriaan E. M. de Steenwinkel, Andreas H. Diacon, Ulrika S. H. Simonsson, Shashikant Srivastava, Sebastian G. Wicha
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
There has been an increased interest in pharmacokinetics and pharmacodynamics (PKPD) of anti-tuberculosis drugs. A better understanding of the relationship between drug exposure, antimicrobial kill and acquired drug resistance is essential not only t
Externí odkaz:
https://doaj.org/article/e4542944f8a243b7ad22068ab5e9346d
Autor:
Edith E. Machowski, Matebogo Letutu, Limakatso Lebina, Ziyaad Waja, Reginah Msandiwa, Minja Milovanovic, Bhavna G. Gordhan, Kennedy Otwombe, Sven O. Friedrich, Richard Chaisson, Andreas H. Diacon, Bavesh Kana, Neil Martinson
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background Pulmonary tuberculosis (TB) in people living with HIV (PLH) frequently presents as sputum smear-negative. However, clinical trials of TB in adults often use smear-positive individuals to ensure measurable bacterial responses follo
Externí odkaz:
https://doaj.org/article/879276020bf045e9ade5f10bfaa38a9d
Autor:
Ahmed A. Abulfathi, Veronique de Jager, Elana van Brakel, Helmuth Reuter, Nikhil Gupte, Naadira Vanker, Grace L. Barnes, Eric Nuermberger, Susan E. Dorman, Andreas H. Diacon, Kelly E. Dooley, Elin M. Svensson
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Meropenem is being investigated for repurposing as an anti-tuberculosis drug. This study aimed to develop a meropenem population pharmacokinetics model in patients with pulmonary tuberculosis and identify covariates explaining inter-indiv
Externí odkaz:
https://doaj.org/article/cadb0a5433cf4817a6465fe5572efa83
Autor:
Conor D. Tweed, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Lerato Mohapi, Michael E. Murphy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Stephen H. Gillespie
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background The phase III REMoxTB study prospectively enrolled HIV-positive (with CD4+ count > 250 cells, not on anti-retroviral therapy) and HIV-negative patients. We investigated the incidence of adverse events and cure rates according to H
Externí odkaz:
https://doaj.org/article/d4f6503cd6b943dbb18e73105c9b0eb8
Autor:
Charissa C. Naidoo, Georgina R. Nyawo, Imran Sulaiman, Benjamin G. Wu, Carolin T. Turner, Kevin Bu, Zaida Palmer, Yonghua Li, Byron W.P. Reeve, Suventha Moodley, Jennifer G. Jackson, Jason Limberis, Andreas H. Diacon, Paul D. van Helden, Jose C. Clemente, Robin M. Warren, Mahdad Noursadeghi, Leopoldo N. Segal, Grant Theron
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103374- (2021)
Background: The relationship between tuberculosis (TB), one of the leading infectious causes of death worldwide, and the microbiome, which is critical for health, is poorly understood. Methods: To identify potential microbiome-host interactions, prof
Externí odkaz:
https://doaj.org/article/2b0b5555619a46c9847ef66452da65ce
Autor:
Rodney Dawson, Andreas H. Diacon, Kim Narunsky, Veronique R. De Jager, Kelly W. Stinson, Xiaoyan Zhang, Yongge Liu, Jeffrey Hafkin
Publikováno v:
Antimicrobial Agents and Chemotherapy.
OPC-167832, an inhibitor of decaprenylphosphoryl-β- d -ribose 2’-oxidase, demonstrated potent antituberculosis activity and a favorable safety profile in preclinical studies. This report describes the first two clinical studies of OPC-167832: (i)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c7ff8a85bf2374ae82d1003e8b21421
https://doi.org/10.1128/aac.01477-22
https://doi.org/10.1128/aac.01477-22
Autor:
Caryn M Upton, Chanel I Steele, Gary Maartens, Andreas H Diacon, Lubbe Wiesner, Kelly E Dooley
Publikováno v:
J Antimicrob Chemother
Background With current treatment options most patients with CNS TB develop severe disability or die. Drug-resistant tuberculous meningitis is nearly uniformly fatal. Novel treatment strategies are needed. Bedaquiline, a potent anti-TB drug, has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9a9be729103000ccdd71f56712a59b
https://doi.org/10.1093/jac/dkac067
https://doi.org/10.1093/jac/dkac067