Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Andreas Gogol-Döring"'
Autor:
Adrian Kovač, Csaba Miskey, Michael Menzel, Esther Grueso, Andreas Gogol-Döring, Zoltán Ivics
Publikováno v:
eLife, Vol 9 (2020)
An ideal tool for gene therapy would enable efficient gene integration at predetermined sites in the human genome. Here we demonstrate biased genome-wide integration of the Sleeping Beauty (SB) transposon by combining it with components of the CRISPR
Externí odkaz:
https://doaj.org/article/4ef11c70bbfa4a3da671a0c28d2a439a
Autor:
Carla Ibañez, Yvonne Poeschl, Tom Peterson, Julia Bellstädt, Kathrin Denk, Andreas Gogol-Döring, Marcel Quint, Carolin Delker
Publikováno v:
BMC Plant Biology, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background Global increase in ambient temperatures constitute a significant challenge to wild and cultivated plant species. Forward genetic analyses of individual temperature-responsive traits have resulted in the identification of several s
Externí odkaz:
https://doaj.org/article/a2c39d7bd77641d999e9a32d01dd4e40
Publikováno v:
PeerJ Computer Science, Vol 5, p e198 (2019)
The rise of high-throughput methods in genomic research greatly expanded our knowledge about the functionality of the genome. At the same time, the amount of available genomic position data increased massively, e.g., through genome-wide profiling of
Externí odkaz:
https://doaj.org/article/17a430da9c0941a5a263792f3420cda8
Autor:
Ivana Grabundzija, Simon A. Messing, Jainy Thomas, Rachel L. Cosby, Ilija Bilic, Csaba Miskey, Andreas Gogol-Döring, Vladimir Kapitonov, Tanja Diem, Anna Dalda, Jerzy Jurka, Ellen J. Pritham, Fred Dyda, Zsuzsanna Izsvák, Zoltán Ivics
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Helitron elements are proposed rolling-circle transposons in eukaryotic genomes, but experimental evidence for their transposition has been lacking. Here, Grabundzija et al. reconstruct an active Helitron from bats which they name Helraiser, and char
Externí odkaz:
https://doaj.org/article/8ad4073178cd4d31a1a49f1829a017bc
Autor:
Anja Tehel, Quynh Vu, Diane Bigot, Andreas Gogol-Döring, Peter Koch, Christina Jenkins, Vincent Doublet, Panagiotis Theodorou, Robert Paxton
Publikováno v:
Viruses, Vol 11, Iss 2, p 114 (2019)
Deformed wing virus (DWV) is an emerging infectious disease of the honey bee (Apis mellifera) that is considered a major cause of elevated losses of honey bee colonies. DWV comprises two widespread genotypes: the originally described genotype A, and
Externí odkaz:
https://doaj.org/article/7b3ed4a2154947069011544fa423a111
Autor:
Yongbo Wang, Andreas Gogol‐Döring, Hao Hu, Sebastian Fröhler, Yunxia Ma, Marvin Jens, Jonas Maaskola, Yasuhiro Murakawa, Claudia Quedenau, Markus Landthaler, Vera Kalscheuer, Dagmar Wieczorek, Yang Wang, Yuhui Hu, Wei Chen
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 9, Pp 1431-1442 (2013)
Abstract RBM10 encodes an RNA binding protein. Mutations in RBM10 are known to cause multiple congenital anomaly syndrome in male humans, the TARP syndrome. However, the molecular function of RBM10 is unknown. Here we used PAR‐CLIP to identify thou
Externí odkaz:
https://doaj.org/article/3e66e3b5cd234cef9361b45be41cadf5
Autor:
Catrin Stutika, Mario Mietzsch, Andreas Gogol-Döring, Stefan Weger, Madlen Sohn, Wei Chen, Regine Heilbronn
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161454 (2016)
Most DNA viruses express small regulatory RNAs, which interfere with viral or cellular gene expression. For adeno-associated virus (AAV), a small ssDNA virus with a complex biphasic life cycle miRNAs or other small regulatory RNAs have not yet been d
Externí odkaz:
https://doaj.org/article/d2713c58ea904d12a7e5e3628cdb3622
Autor:
Giandomenico Turchiano, Maria Carmela Latella, Andreas Gogol-Döring, Claudia Cattoglio, Fulvio Mavilio, Zsuzsanna Izsvák, Zoltán Ivics, Alessandra Recchia
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112712 (2014)
The Sleeping Beauty (SB) transposon is a non-viral integrating vector system with proven efficacy for gene transfer and functional genomics. However, integration efficiency is negatively affected by the length of the transposon. To optimize the SB tr
Externí odkaz:
https://doaj.org/article/eefaa821432f40aaad927477eac03a9c
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32750 (2012)
Epigenetic regulation of gene expression is commonly altered in human cancer. We have observed alterations of DNA methylation and microRNA expression that reflect the biology of bladder cancer. This common disease arises by distinct pathways with low
Externí odkaz:
https://doaj.org/article/f89371b4896e4b71990900e451306e06
Autor:
Daniela Hüser, Andreas Gogol-Döring, Timo Lutter, Stefan Weger, Kerstin Winter, Eva-Maria Hammer, Toni Cathomen, Knut Reinert, Regine Heilbronn
Publikováno v:
PLoS Pathogens, Vol 6, Iss 7, p e1000985 (2010)
Adeno-associated virus type 2 (AAV) is known to establish latency by preferential integration in human chromosome 19q13.42. The AAV non-structural protein Rep appears to target a site called AAVS1 by simultaneously binding to Rep-binding sites (RBS)
Externí odkaz:
https://doaj.org/article/eb0261c9c280413a82730aee381124c9