Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andreas Gerhard Weichert"'
Autor:
Andre Boelke, Emily Jane Canada, Brian Morgan Watson, Valentine J. Klimkowski, Michael Mohr, Qing Shi, David E. Timm, Shon Roland Pulley, Andreas Gerhard Weichert, Hans-Juergen Mest, J. Michael Kalbfleisch, Elizabeth A. Dingess-Hammond, Johann-Christian Zechel, Gerd Ruehter, Brandon J. Margolis, Soenke Petersen, Michael Robert Wiley, Graham N. Wishart, Annick J. Cauvin, Beatrice Renson, Stephen Parsons, Larry C. Blaszczak, Dirk Hankotius, Britta Evers, Scott Martin Sheehan
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(6)
A series of non-covalent inhibitors of the serine protease dipeptidyl peptidase IV (DPP-IV) were found to adopt a U-shaped binding conformation in X-ray co-crystallization studies. Remarkably, Tyr547 undergoes a 70 degrees side-chain rotation to acco
Publikováno v:
ChemInform. 37
A new, two-step synthesis of oxazolopyridines is described. The synthesis involving amide formation between o -aminopyridinols and aliphatic or aromatic carboxylic acids followed by condensation with hexachloroethane/triphenylphosphine takes place at
Autor:
María Luz de la Puente, David Gene Barrett, Martina Berg, Benjamin Bonnier, Stefan Heuser, Ulrike Roettig, David J. Steggles, Erich Seger, Astrid Kahl, Niall Oram, Gema Sanz Gil, Rainer Riedl, Jutta Wanner, Andreas Gerhard Weichert
A synthetic route towards cyclopropylic compounds, which act as glucokinase activators is described herein. The present synthesis gives easy and rapid access to a wide variety of either sulfones or sulfonamides starting from readily available late-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf5b8d7f2c4c3ea5d6a951f5db9e12b
https://hdl.handle.net/11475/2758
https://hdl.handle.net/11475/2758
Autor:
David Gene Barrett, Yong Wang, Stephen L. Briggs, Mark Radloff, Jim D. Durbin, Jesper Gromada, Haihong Guo, Alexander M. Efanov, Gema Sanz Gil, Andreas Gerhard Weichert, Andrea Zaliani, Martin B. Brenner, Annie Delaunois, Sabine Sewing, Ulrich Giese
Publikováno v:
Endocrinology. 146(9)
The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We report here the effects of a novel glucokinase activator, LY2121260. The activator enhanced GK activity via binding to the allosteric site located in the hinge reg