Engineered bacteria to accelerate wound healing: an adaptive, randomised, double-blind, placebo-controlled, first-in-human phase 1 trialResearch in context

Autor: Emelie Öhnstedt, Evelina Vågesjö, Andreas Fasth, Hava Lofton Tomenius, Pia Dahg, Sofia Jönsson, Nisha Tyagi, Mikael Åström, Zhanar Myktybekova, Lovisa Ringstad, Margareth Jorvid, Peter Frank, Per Hedén, Stefan Roos, Mia Phillipson

Publikováno v: EClinicalMedicine, Vol 60, Iss , Pp 102014- (2023)

Summary: Background: Impaired wound healing is a growing medical problem and very few approved drugs with documented clinical efficacy are available. CXCL12-expressing lactic acid bacteria, Limosilactobacillus reuteri (ILP100-Topical), has been demon

Externí odkaz: https://doaj.org/article/e9a33a7d869746a6a7dab3edaf7c422f

Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity

Autor: Melum, Vebjørn Jacobsen, Sáenz de Miera, Cristina, Markussen, Fredrik Andreas Fasth, Cazarez Marquez, Fernando, Jaeger, Catherine, Sandve, Simen Rød, Simonneaux, Valérie, Hazlerigg, David Grey, Wood, Shona Hiedi

Publikováno v: Melum, Sáenz de Miera, Markussen, Cazarez Marquez, Jaeger, Sandve, Simonneaux, Hazlerigg, Wood. Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity. Current Biology. 2024;34(3):632-640.e6

Externí odkaz: https://hdl.handle.net/10037/35128

How can we optimize the development of drugs for wound healing?

Autor: Mia Phillipson, Andreas Fasth, Patricia Grigoleit, Evelina Vågesjö

Publikováno v: Expert Opinion on Drug Discovery

Non-healing wounds, i.e., skin wounds that have failed to heal within 6 weeks, form a silent, global epidemic in the expanding aging and diabetic population. In addition to aging and diabetes, know...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3eaeb77c8ad049e30b1d394f4d85580
https://pubmed.ncbi.nlm.nih.gov/34651533