Výsledky vyhledávání - "Andreas F. G. Glawar"

Akademický článek

2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-l-xylitol (N-benzyl-l-XYLNAc)

Autor: Sarah. F. Jenkinson, Elizabeth. V. Crabtree, Andreas. F. G. Glawar, Terry D. Butters, George. W. J. Fleet, David. J. Watkin

Publikováno v: Acta Crystallographica Section E, Vol 66, Iss 5, Pp o1147-o1148 (2010)

X-ray crystallography defines the relative configuration at the three-stereogenic centres in the title compound N-benzyl-l-XYLNAc, C14H20N2O3. The five-membered pyrrolidine ring adopts an envelope conformation with the N atom lying out of the plane o

Externí odkaz: https://doaj.org/article/a8384492d10549cbb8a87a8a6ca7f2b1

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Nine of 16 Stereoisomeric Polyhydroxylated Proline Amides Are Potent β-N-Acetylhexosaminidase Inhibitors

Autor: Sarah F. Jenkinson, Isao Adachi, Benjamin James Ayers, Atsushi Kato, Mark R. Wormald, Chu-Yi Yu, Nigel Ngo, Zilei Liu, Robert J. Nash, George W. J. Fleet, R. Fernando Martínez, Shinpei Nakagawa, Andreas F. G. Glawar, Terry D. Butters

Publikováno v: The Journal of Organic Chemistry. 79:3398-3409

All 16 stereoisomeric N-methyl 5-(hydroxymethyl)-3,4-dihydroxyproline amides have been synthesized from lactones accessible from the enantiomers of glucuronolactone. Nine stereoisomers, including all eight with a (3R)-hydroxyl configuration, are low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7acdd17a1a1121453462f462fa650aa
https://doi.org/10.1021/jo500157p

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Kurz und knapp:L-Glucose undL-Glucuronsäure ausD-Glucose

Autor: Zilei Liu, Sarah F. Jenkinson, Andreas F. G. Glawar, R. Fernando Martínez, George W. J. Fleet, Akihide Yoshihara, Ken Izumori

Publikováno v: Angewandte Chemie. 126:1179-1182

Das seltene Vorkommen und die Kosten der Herstellung von L-Zuckern und anderen seltenen Zuckern haben die volle Ausschopfung ihres biologischen Potenzials bisher verhindert; zum Beispiel D-Psicose, erst seit kurzem verfugbar, ist schon als wichtiges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24ed67f1c18c999e3012baf293c948d2
https://doi.org/10.1002/ange.201309073

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Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids

Autor: Andreas F. G. Glawar, N. Ngo, Atsushi Kato, R. F. Martínez, Sarah F. Jenkinson, George W. J. Fleet, Benjamin James Ayers, Shinpei Nakagawa, Michael A. Hollas, Terry D. Butters

Publikováno v: Organicbiomolecular chemistry. 14(44)

This paper explores the computer modelling aided design and synthesis of β-N-acetylhexosaminidase inhibitors along with their applicability to human disease treatment through biological evaluation in both an enzymatic and cellular setting. We invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17eb1c1f299b677add200f1917e76857
https://pubmed.ncbi.nlm.nih.gov/27735004

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Isopropyl 2,5-anhydro-3,4-di-O-tert-butyldiphenyl-silyl-L-ribonate

Autor: George W. J. Fleet, David J. Watkin, Alison A. Edwards, George E. Tranter, Andreas F. G. Glawar, Gangadhar J. Sanjayan

Determination of the crystal structure of the title compound, C 40H50O5Si2, firmly established its relative configuration and hence that of some related tetrahydrofuran carboxylates. The material crystallizes with Z′ = 2. Except for the chiral cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9c7f68bc71f926e8a06e7e973408f8
https://ora.ox.ac.uk/objects/uuid:d2428b20-f674-4125-bbbb-642809ff4266

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