Vascular surveillance by haptotactic blood platelets in inflammation and infection

Autor: Leo Nicolai, Karin Schiefelbein, Silvia Lipsky, Alexander Leunig, Marie Hoffknecht, Kami Pekayvaz, Ben Raude, Charlotte Marx, Andreas Ehrlich, Joachim Pircher, Zhe Zhang, Inas Saleh, Anna-Kristina Marel, Achim Löf, Tobias Petzold, Michael Lorenz, Konstantin Stark, Robert Pick, Gerhild Rosenberger, Ludwig Weckbach, Bernd Uhl, Sheng Xia, Christoph Andreas Reichel, Barbara Walzog, Christian Schulz, Vanessa Zheden, Markus Bender, Rong Li, Steffen Massberg, Florian Gaertner

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector funct

Externí odkaz: https://doaj.org/article/4823a6cec2a1460586e33e31ba7a0aef

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

Autor: Joachim Pircher, Thomas Czermak, Andreas Ehrlich, Clemens Eberle, Erik Gaitzsch, Andreas Margraf, Jochen Grommes, Prakash Saha, Anna Titova, Hellen Ishikawa-Ankerhold, Konstantin Stark, Tobias Petzold, Thomas Stocker, Ludwig T Weckbach, Julia Novotny, Markus Sperandio, Bernhard Nieswandt, Alberto Smith, Hanna Mannell, Barbara Walzog, David Horst, Oliver Soehnlein, Steffen Massberg, Christian Schulz

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Cathelicidins are antimicrobial peptides that eliminate pathogens and contribute to the innate immune response. Here the authors show that neutrophil-derived LL-37/CRAMP induces platelet activation and promotes arterial thrombosis and thrombo-inflamm

Externí odkaz: https://doaj.org/article/8a00ffc239a5482690c1439aabca24d4

Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1

Autor: Enzo Lüsebrink, Inas Saleh, René M'Pembele, Manuela Thienel, Philipp Mourikis, Franz Röschenthaler, Christoph H. Mayr, Lisa Dannenberg, Thomas J. Stocker, Kajetan Trojovky, Joachim Pircher, Christian Jung, Alina Achilles, Richard Brandl, Bodo Levkau, Till Hoffmann, Tobias Zeus, Zhe Zhang, Norbert Gerdes, Thomas Hohlfeld, Andreas Ehrlich, Michael Spannagl, Daniel Konsek, Malte Kelm, Carolin Helten, Christian Schulz, Ron Regenauer, Herbert B. Schiller, Jan Strecker, Aysel Ayhan, Leo Nicolai, Tobias Petzold, Amin Polzin

Publikováno v: Circulation Research. 126:486-500

Rationale: A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban compared with vitamin K antagonists. At the same time, low-dose rivaroxaban has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8bedea63187b550b56b521d05fccf5
https://doi.org/10.1161/circresaha.119.315099

Role of RXRβ in platelet function and arterial thrombosis

Autor: Joachim Pircher, Enzo Lüsebrink, Steffen Massberg, Verena Warm, Pierre Chambon, Christian Schulz, Andreas Ehrlich, Zhe Zhang, Tobias Petzold, Jan Strecker

Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 2019, 17 (9), pp.1489-1499. ⟨10.1111/jth.14531⟩

OBJECTIVE: Retinoid X receptors (RXR) are a family of nuclear receptors that play critical roles in the regulation of numerous fundamental biological processes including cell proliferation, differentiation, and death. Earlier studies suggested that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eefee2c6216eb73cc06fcfa6f701740
https://doi.org/10.1111/jth.14531

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3

Autor: Benjamin Busch, Veit Hornung, Gesine Behrens, Matthias von Gamm, Wolfgang Wurst, Arie Geerlof, Johannes Lichti, Regina Feederle, Annalisa Schaub, Dhruv Chauhan, Elke Glasmacher, Katharina Essig, Annette Feuchtinger, Alisha N Jones, Christine Wolf, Andreas Ehrlich, Caroline C. Friedel, Kathrin Davari, Vigo Heissmeyer, Michael Sattler, Matthias H. Tschöp, Mathias Heikenwalder, Joachim Pircher, Anna Macht, Christian Schulz, Stefanie M. Hauck

Publikováno v: J. Exp. Med. 216, 1700-1723 (2019)
The Journal of Experimental Medicine
Journal of experimental medicine 216(7), 1700-1723 (2019). doi:10.1084/jem.20181762

von Gamm et al. demonstrate that mice deficient for the RNase Regnase-3 (Zc3h12c) develop hypertrophic lymph nodes and a systemic interferon response. Regnase-3 is a functional RNase that acts in myeloid cells upon IRF signaling, suggesting it to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6ae2c005f84820cba549cbfe6e849d
https://doi.org/10.1084/jem.20181762