Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Andreas Dendorfer"'
Autor:
Hengliang Zhang, Payel Sen, Jules Hamers, Theresa Sittig, Brent Woestenburg, Allessandra Moretti, Andreas Dendorfer, Daphne Merkus
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other non-cardiomyocyte cells. Retinoic acid (RA) plays an important role in r
Externí odkaz:
https://doaj.org/article/236e8f7b4280464d849755516f0aea5b
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Dysfunctional Ca2+ signaling affects the myocardial systole and diastole, may trigger arrhythmia and cause transcriptomic and proteomic modifications in heart failure. Thus, synchronous real-time measurement of Ca2+ and force is essential to
Externí odkaz:
https://doaj.org/article/6d50eb6e3e1645eda58e373fd49ac088
Autor:
Mariana Shumliakivska, Guillermo Luxán, Inga Hemmerling, Marina Scheller, Xue Li, Carsten Müller-Tidow, Bianca Schuhmacher, Zhengwu Sun, Andreas Dendorfer, Alisa Debes, Simone-Franziska Glaser, Marion Muhly-Reinholz, Klara Kirschbaum, Jedrzej Hoffmann, Eike Nagel, Valentina O. Puntmann, Sebastian Cremer, Florian Leuschner, Wesley Tyler Abplanalp, David John, Andreas M. Zeiher, Stefanie Dimmeler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha (DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential (CHIP), and are associated with unfavorable outcomes in patients suf
Externí odkaz:
https://doaj.org/article/20a09696ec974f6db501fff88d7fff78
Publikováno v:
Bio-Protocol, Vol 13, Iss 13 (2023)
Cardiovascular diseases are the leading cause of death and morbidity worldwide. Patient mortality has been successfully reduced by nearly half in the last four decades, mainly due to advances in minimally invasive surgery techniques and interventiona
Externí odkaz:
https://doaj.org/article/81e6bd6e343748d9a273277fed595f60
Autor:
Dena Esfandyari, Bio Maria Ghéo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grüter, Melanie Annemarie Meier, Anna Christina Näger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.
Externí odkaz:
https://doaj.org/article/d85bf05b483c4f8fbfb7b8bb9f690c4b
Autor:
Thirupura S. Shankar, Dinesh K. A. Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, Aspasia Thodou Krokidi, Dallen Calder, Sutip Navankasattusas, Paulina Sander, Oh Sung Kwon, Aishwarya Aravamudhan, Jing Ling, Andreas Dendorfer, Changmin Xie, Ohyun Kwon, Emily H. Y. Cheng, Kevin J. Whitehead, Thomas Gudermann, Russel S. Richardson, Frank B. Sachse, Johann Schredelseker, Kenneth W. Spitzer, Dipayan Chaudhuri, Stavros G. Drakos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart f
Externí odkaz:
https://doaj.org/article/5def0b8a41bf407088eed68a7df3942d
Autor:
Xiaochun Cao-Ehlker, Carola Fischer, Kun Lu, Tobias Bruegmann, Philipp Sasse, Andreas Dendorfer, Roland Tomasi
Publikováno v:
Bioengineering, Vol 10, Iss 2, p 171 (2023)
Organotypic heart slices from mice might provide a promising in vitro model for cardiac research because of the vast availability of genetically modified specimens, combined with the unrestricted feasibility of experimental interventions. However, mu
Externí odkaz:
https://doaj.org/article/49e70150c12e41e6a492d76f511dc30f
Autor:
Carola Fischer, Hendrik Milting, Evelyn Fein, Elisabeth Reiser, Kun Lu, Thomas Seidel, Camilla Schinner, Thomas Schwarzmayr, Rene Schramm, Roland Tomasi, Britta Husse, Xiaochun Cao-Ehlker, Ulrich Pohl, Andreas Dendorfer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable
Externí odkaz:
https://doaj.org/article/b0d54360a0484bdfbbb91bce79c8f903
Autor:
Maha Abu-Khousa, Dominik J. Fiegle, Sophie T. Sommer, Ghazali Minabari, Hendrik Milting, Christian Heim, Michael Weyand, Roland Tomasi, Andreas Dendorfer, Tilmann Volk, Thomas Seidel
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The normally positive cardiac force-frequency relationship (FFR) becomes flat or negative in chronic heart failure (HF). Here we explored if remodeling of the cardiomyocyte transverse tubular system (t-system) is associated with alterations in FFR an
Externí odkaz:
https://doaj.org/article/78ea67220bcb4439b18b746f91e17008
Autor:
Julia Jeannine Jung, Britta Husse, Christian Rimmbach, Stefan Krebs, Juliane Stieber, Gustav Steinhoff, Andreas Dendorfer, Wolfgang-Michael Franz, Robert David
Publikováno v:
Stem Cell Reports, Vol 2, Iss 5, Pp 592-605 (2014)
Therapeutic approaches for “sick sinus syndrome” rely on electrical pacemakers, which lack hormone responsiveness and bear hazards such as infection and battery failure. These issues may be overcome via “biological pacemakers” derived from pl
Externí odkaz:
https://doaj.org/article/eb164d8eddd342b28bb5a824538203dd