Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andreas Danzer"'
Autor:
Adrian Krummnow, Andreas Danzer, Kristin Voges, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1395 (2023)
The poor bioavailability of an active pharmaceutical ingredient (API) can be enhanced by dissolving it in a polymeric matrix. This formulation strategy is commonly known as amorphous solid dispersion (ASD). API crystallization and/or amorphous phase
Externí odkaz:
https://doaj.org/article/bb69911e81364571a3da478b65b7215f
Publikováno v:
Micromachines, Vol 13, Iss 10, p 1795 (2022)
There is an increasing focus on two-phase flow in micro- or mini-structured apparatuses for various manufacturing and measurement instrumentation applications, including the field of crystallization as a separation technique. The slug flow pattern of
Externí odkaz:
https://doaj.org/article/d0222415a1954aee98a0837aefe970ad
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1897 (2022)
Anomalous water-sorption kinetics in amorphous solid dispersions (ASDs) are caused by the slow swelling of the polymer. In this work, we used a diffusion–relaxation model with the Williams–Landel–Ferry (WLF) equation and the Arrhenius equation
Externí odkaz:
https://doaj.org/article/8efe8b382d894692a0b9fd3587b34113
Autor:
Adrian Krummnow, Andreas Danzer, Kristin Voges, Stefanie Dohrn, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1904 (2022)
In amorphous solid dispersions (ASDs), an active pharmaceutical ingredient (API) is dissolved on a molecular level in a polymeric matrix. The API is expected to be released from the ASD upon dissolution in aqueous media. However, a series of earlier
Externí odkaz:
https://doaj.org/article/a6f4f826bd9d43f4a239692d5477d985
Autor:
Raj Schneider, Jana Kerkhoff, Andreas Danzer, Amelie Mattusch, Andrijan Ohmann, Markus Thommes, Gabriele Sadowski
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100063- (2020)
Supersaturation profiles of amorphous indomethacin in aqueous solution containing 0.4 wt% and 4 wt% of isopropanol were predicted by combining separately-determined kinetics for dissolution, solution crystallization, and solid-state transformation. T
Externí odkaz:
https://doaj.org/article/0f8b03284ad04b0893bfb00f559a8721
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1181 (2022)
Water decreases the stability of amorphous solid dispersions (ASDs) and water sorption is, therefore, unwanted during ASD storage. This work suggests a methodology to predict the water-sorption isotherms and the water-sorption kinetics in amorphous p
Externí odkaz:
https://doaj.org/article/0d545d9f73fd45dc820bde07e4460aa5
Publikováno v:
Membranes, Vol 12, Iss 4, p 434 (2022)
Polyvinylpyrrolidone (PVP)-based polymers are excellent stabilizers for food supplements and pharmaceutical ingredients. However, they are highly hygroscopic. This study measured and modeled the water-sorption isotherms and water-sorption kinetics in
Externí odkaz:
https://doaj.org/article/265132e3806d42c4bc1d61d459ee4a67
Publikováno v:
Molecular Pharmaceutics. 20:2568-2578
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72cfda157169ca746771ceecae1cd799
https://doi.org/10.1021/acs.molpharmaceut.3c00008
https://doi.org/10.1021/acs.molpharmaceut.3c00008
Publikováno v:
Molecular Pharmaceutics. 20:2194-2206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef9b1d33b14d739e424d06c6f7feff4
https://doi.org/10.1021/acs.molpharmaceut.3c00006
https://doi.org/10.1021/acs.molpharmaceut.3c00006
Publikováno v:
The Journal of Supercritical Fluids. 200:105990
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::931c612283ebcb05e416c442a9ec71bd
https://doi.org/10.1016/j.supflu.2023.105990
https://doi.org/10.1016/j.supflu.2023.105990