Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Andreas Czich"'
Publikováno v:
Chemical Research in Toxicology. 35:2068-2084
Autor:
David, Kirkland, Marilyn J, Aardema, Rüdiger V, Battersby, Carol, Beevers, Karin, Burnett, Arne, Burzlaff, Andreas, Czich, E Maria, Donner, Paul, Fowler, Helinor J, Johnston, Harald F, Krug, Stefan, Pfuhler, Leon F, Stankowski
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 136
Titanium dioxide is a ubiquitous white material found in a diverse range of products from foods to sunscreens, as a pigment and thickener, amongst other uses. Titanium dioxide has been considered no longer safe for use in foods (nano and microparticl
Autor:
Joel P. Bercu, Melisa Masuda-Herrera, Alejandra Trejo-Martin, Priyanka Sura, Robert Jolly, Michelle Kenyon, Rob Thomas, David J. Ponting, David Snodin, Gregor Tuschl, Stephanie Simon, Kathleen De Vlieger, Richard Hutchinson, Andreas Czich, Susanne Glowienke, M. Vijayaraj Reddy, Sandra Johanssen, Esther Vock, Nancy Claude, Richard J. Weaver
Publikováno v:
Regulatory Toxicology and Pharmacology. :105415
Autor:
Alejandra Trejo-Martin, Joel P. Bercu, Andrew Thresher, Rachael E. Tennant, Robert F. Thomas, Kevin Cross, Andreas Czich, Kerstin Waese, John J. Nicolette, Joel Murray, Paul Sonders, Alison Kondratiuk, Jennifer R. Cheung, Dean Thomas, Anthony Lynch, James Harvey, Susanne Glowienke, Laura Custer, Patricia A. Escobar
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 135
Under ICH M7, impurities are assessed using the bacterial reverse mutation assay (i.e., Ames test) when predicted positive using in silico methodologies followed by expert review. N-Nitrosamines (NAs) have been of recent concern as impurities in phar
Publikováno v:
Chemical research in toxicology. 32(11)
One of the most appreciated capabilities of computational toxicology is to support the design of pharmaceuticals with reduced toxicological hazard. To this end, we have strengthened our drug photosafety assessments by applying novel computer models f
Autor:
Peter Kasper, Rolf Fautz, Andreas Zeller, Frank Bringezu, Stefan Pfuhler, Nicola J. Hewitt, Silvio Albertini, Yasmin Dietz, Andreas Czich, Annette Kirst
Publikováno v:
Mutagenesis. 33:179-193
Genotoxicity testing is an important part of standard safety testing strategies. Animal studies have always been a key component, either as a mandatory part of the regulatory test battery, or to follow-up questionable in vitro findings. The strengths
Autor:
David J. Ponting, Michelle O. Kenyon, Melisa Masuda-Herrera, Angela White, Robert Thomas, Maria Augusta C. Rodrigues, Joel P. Bercu, Fernanda Waechter, Andreas Czich, George E. Johnson, Kevin P. Cross, Susanne Glowienke
Publikováno v:
Regulatory Toxicology and Pharmacology. 123:104926
The ICH M7(R1) guideline describes a framework to assess the carcinogenic risk of mutagenic and carcinogenic pharmaceutical impurities following less-than-lifetime (LTL) exposures. This LTL framework is important as many pharmaceuticals are not admin
Autor:
Friedemann Schmidt, Alexander Amberg, Manuela Stolte, Andreas Czich, Hans-Peter Spirkl, Denis Mulliner
Publikováno v:
Chemical Research in Toxicology. 29:757-767
Hepatic toxicity is a key concern for novel pharmaceutical drugs since it is difficult to anticipate in preclinical models, and it can originate from pharmacologically unrelated drug effects, such as pathway interference, metabolism, and drug accumul
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
For regulatory information requirements, developmental toxicity testing is often conducted in two mammalian species. In order to provide a set of reference compounds that could be used to explore alternative approaches to supersede testing in a secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573b5cab9fab9fe6900f9b9ff51f874d
http://hdl.handle.net/2445/165321
http://hdl.handle.net/2445/165321
Autor:
David P. Elder, Alexander Amberg, James Harvey, Sharon Robinson, Hans-Peter Spirkl, Angela White, Andreas Czich
Publikováno v:
Organic Process Research & Development. 19:1495-1506
A substantial amount of mutagenicity data on acyl/sulfonyl halides is available in the public domain, and these data are the basis for many in silico models of mutagenicity (e.g., Derek Nexus and Leadscope). A review of these data indicates that the