Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andreas Borst"'
Autor:
José Vicente Gomes-Filho, Ruth Breuer, Hector Gabriel Morales-Filloy, Nadiia Pozhydaieva, Andreas Borst, Nicole Paczia, Jörg Soppa, Katharina Höfer, Andres Jäschke, Lennart Randau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract NAD is a coenzyme central to metabolism that also serves as a 5′-terminal cap for bacterial and eukaryotic transcripts. Thermal degradation of NAD can generate nicotinamide and ADP-ribose (ADPR). Here, we use LC-MS/MS and NAD captureSeq to
Externí odkaz:
https://doaj.org/article/b2bd0d8d07d04d60867ee100d9ab99d3
Autor:
Madeleine Huber, Nico Vogel, Andreas Borst, Friedhelm Pfeiffer, Svetlana Karamycheva, Yuri I. Wolf, Eugene V. Koonin, Jörg Soppa
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Genomes of bacteria and archaea contain a much larger fraction of unidirectional (serial) gene pairs than convergent or divergent gene pairs. Many of the unidirectional gene pairs have short overlaps of −4 nt and −1 nt. As shown previously, trans
Externí odkaz:
https://doaj.org/article/2913daaa04154072820da5ef8a4ae4e5
Autor:
Deniz Üresin, Dennis J. Pyper, Andreas Borst, Lydia Hadjeras, Rick Gelhausen, Rolf Backofen, Cynthia Sharma, Harald Schwalbe, Jörg Soppa
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
It is increasingly recognized that very small proteins (μ-proteins) are ubiquitously found in all species of the three domains of life, and that they fulfill important functions. The halophilic archaeon Haloferax volcanii contains 282 μ-proteins of
Externí odkaz:
https://doaj.org/article/5e3c294724f24213b6494198bc242a45
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Translation is an important step in gene expression. Initiation of translation is rate-limiting, and it is phylogenetically more diverse than elongation or termination. Bacteria contain only three initiation factors. In stark contrast, eukaryotes con
Externí odkaz:
https://doaj.org/article/faf199bfbeef47e086316e844130e12f
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Gene conversion is defined as the non-reciprocal transfer of genetic information from one site to a homologous, but not identical site of the genome. In prokaryotes, gene conversion can increase the variance of sequences, like in antigenic variation,
Externí odkaz:
https://doaj.org/article/a199aa4f52074a02b857e35d9fa53eaf
Autor:
Johannes, Grimm, Anita, Hufnagel, Marion, Wobser, Andreas, Borst, Sebastian, Haferkamp, Roland, Houben, Svenja, Meierjohann
Publikováno v:
Oncogenesis, Vol 7, Iss 9, Pp 1-12 (2018)
Approximately half of all melanoma patients harbour activating mutations in the serine/threonine kinase BRAF. This is the basis for one of the main treatment strategies for this tumor type, the targeted therapy with BRAF and MEK inhibitors. While the
Autor:
Martin Fenk, Dina Grohmann, Jörg Soppa, Sébastien Ferreira-Cerca, Andreas Borst, Robert Knüppel, Felix Grünberger, Winfried Hausner, Robert Reichelt, Michael Jüttner
The prokaryotic transcriptome is shaped by transcriptional and posttranscriptional events that define the characteristics of an RNA, including transcript boundaries, the base modification status, and processing pathways to yield mature RNAs. Currentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a0bb1a3b2432e254050d074b97f480
https://doi.org/10.1101/2019.12.18.880849
https://doi.org/10.1101/2019.12.18.880849
Publikováno v:
FEMS microbiology letters. 366(21)
In haloarchaea, a cluster of three genes is localized directly adjacent to the major replication origin, and, hence, the encoded proteins were annotated as ‘origin-associated proteins’ (Oap). However, prior to this study, no experimental data wer
Autor:
Sebastian Haferkamp, Johannes Grimm, Svenja Meierjohann, Sen Guo, Chunying Li, Guannan Zhu, Roland Houben, Andreas Borst, Tianwen Gao, David Schrama, Manuel Rösch
Publikováno v:
Cancer letters. 404
In patients with BRAF-mutated melanoma specific inhibitors of BRAFV600E and MEK1/2 frequently induce initial tumor reduction, frequently followed by relapse. As demonstrated previously, BRAFV600E-inhibition induces apoptosis only in a fraction of tre
Autor:
Marion Wobser, Sebastian Haferkamp, Roland Houben, Claus-Jürgen Scholz, Sabrina Angermeyer, Katharina Wiedorfer, Lisa Pfitzer, Andreas Borst, Sonja Hesbacher, David Schrama
Publikováno v:
Oncotarget
The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing tumor suppressive properties. Indeed, the PPs jointly control the G1/S transition mainly by inhibiting E2F transcription factors. Notably, several viral on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f07f6a9b0522ec437c3994036a6aa
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17785
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17785