Zobrazeno 1 - 10
of 556
pro vyhledávání: '"Andreas Bernkop-Schnürch"'
Enhanced Mucoadhesion of Thiolated β‑Cyclodextrin by S‑Protection with 2‑Mercaptoethanesulfonic Acid
Autor:
Gergely Kali, Ali Magdi Mahmoud Mahmoud Taha, Emiliano Campanella, Martyna Truszkowska, Soheil Haddadzadegan, Nunzio Denora, Andreas Bernkop-Schnürch
Publikováno v:
ACS Omega, Vol 9, Iss 5, Pp 5819-5828 (2024)
Externí odkaz:
https://doaj.org/article/c9c0802d02884772b80a8738a1a103e4
Autor:
Ahmad Saleh, Zeynep Burcu Akkuş-Dağdeviren, Julian David Friedl, Patrick Knoll, Andreas Bernkop-Schnürch
Publikováno v:
Heliyon, Vol 8, Iss 9, Pp e10577- (2022)
The aim of this study was to develop nanoparticles (NPs) providing a targeted drug release directly on the epithelium of the intestinal mucosa.NPs were prepared via ionic gelation between cationic chitosan (Cs) and anionic polyphosphate (PP). The res
Externí odkaz:
https://doaj.org/article/d209a2b96a334d54bd1587672259809e
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1993 (2023)
Aim: This study aims to design a novel thiolated κ-carrageenan (κ-CA-SH) and evaluate its potential as an excipient for the design of mucoadhesive drug delivery systems. Methods: Native κ-carrageenan (κ-CA) was thiolated with phosphorous pentasul
Externí odkaz:
https://doaj.org/article/c6b802d5d6e84ae4a969ac917afea84b
Autor:
Nathalie Hock, Giuseppe Francesco Racaniello, Sam Aspinall, Nunzio Denora, Vitaliy V. Khutoryanskiy, Andreas Bernkop‐Schnürch
Publikováno v:
Advanced Science, Vol 9, Iss 1, Pp n/a-n/a (2022)
Abstract Advances in nanotechnology have generated a broad range of nanoparticles (NPs) for numerous biomedical applications. Among the various properties of NPs are functionalities being related to thiol substructures. Numerous biological processes
Externí odkaz:
https://doaj.org/article/8deb9f8e384c4c6084afbc95332d87db
Autor:
Brunella Grassiri, Andrea Cesari, Federica Balzano, Chiara Migone, Gergely Kali, Andreas Bernkop-Schnürch, Gloria Uccello-Barretta, Ylenia Zambito, Anna Maria Piras
Publikováno v:
Polymers, Vol 14, Iss 15, p 3170 (2022)
Thiolated cyclodextrins are structurally simple mucoadhesive macromolecules, which are able to host drugs and increase their apparent water solubility, as well as interact with the mucus layer prolonging drug residence time on the site of absorption.
Externí odkaz:
https://doaj.org/article/256c08a5f7834a9aac957f09c907fd55
Autor:
Atiđa Selmani, Elisabeth Seibert, Carolin Tetyczka, Doris Kuehnelt, Ivan Vidakovic, Karin Kornmueller, Markus Absenger-Novak, Borna Radatović, Ivana Vinković Vrček, Gerd Leitinger, Eleonore Fröhlich, Andreas Bernkop-Schnürch, Eva Roblegg, Ruth Prassl
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 803 (2022)
This study aimed to design a hybrid oral liposomal delivery system for selenium nanoparticles (Lip-SeNPs) to improve the bioavailability of selenium. Thiolated chitosan, a multifunctional polymer with mucoadhesive properties, was used for surface fun
Externí odkaz:
https://doaj.org/article/a16fa600c046460eb68bfd182466d814
Autor:
Brunella Grassiri, Patrick Knoll, Angela Fabiano, Anna Maria Piras, Ylenia Zambito, Andreas Bernkop-Schnürch
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2612 (2022)
The goal of this study was the design and evaluation of a thiolated cyclodextrin providing high drug solubilizing and mucoadhesive properties for ocular drug delivery. Hydroxypropyl-β-cyclodextrin (HP-β-CD) was thiolated via a microwave-assisted me
Externí odkaz:
https://doaj.org/article/d53ffe5144764dd2904ff02f2693d40f
Targeted Self-Emulsifying Drug Delivery Systems to Restore Docetaxel Sensitivity in Resistant Tumors
Autor:
Virginia Campani, Iris Chiara Salaroglio, Valeria Nele, Joanna Kopecka, Andreas Bernkop-Schnürch, Chiara Riganti, Giuseppe De Rosa
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 292 (2022)
The use of chemotherapeutic agents such as docetaxel (DTX) in anticancer therapy is often correlated to side effects and the occurrence of drug resistance, which substantially impair the efficacy of the drug. Here, we demonstrate that self-emulsifyin
Externí odkaz:
https://doaj.org/article/b05a6b68b8d442d8aa326c81eb38b610
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1312 (2021)
This study was aimed to evaluate the impact of surfactants used for nanostructured lipid carriers (NLCs) to provide enzymatic protection for incorporated peptides. Insulin as a model peptide was ion paired with sodium dodecyl sulfate to improve its l
Externí odkaz:
https://doaj.org/article/35fd015410b14fb6b90bcd90d0e3ad23
Autor:
Iram Shahzadi, Andrea Fürst, Zeynep Burcu Akkus-Dagdeviren, Shumaila Arshad, Markus Kurpiers, Barbara Matuszczak, Andreas Bernkop-Schnürch
Publikováno v:
Polymers, Vol 12, Iss 6, p 1259 (2020)
As less reactive s-protected thiomers can likely interpenetrate the mucus gel layer to a higher extent before getting immobilized via disulfide bond formation with mucins, it was the aim of this study to develop a novel type of s-protected thiomer ba
Externí odkaz:
https://doaj.org/article/8a15c4fa515d4ff7ad07b6ab41abfc77