Výsledky vyhledávání - "Andreas Berdeja"

Improving RNA Interference in Mammalian Cells by 4‘-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2‘-O-Alkyl Modifications

Autor: Balkrishen Bhat, Hans Gaus, Russell Jarres, Andreas Berdeja, Namir Sioufi, Prasad Dande, Eric E. Swayze, Richard H. Griffey, Thazha P. Prakash

Publikováno v: Journal of Medicinal Chemistry. 49:1624-1634

A systematic structure-activity relationship study of 4'-thioribose containing small interfering RNAs (siRNAs) has led to the identification of highly potent and stable antisense constructs. To enable this optimization effort for both in vitro and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d90a3f41f1372debd6ef5fbb1adee8
https://doi.org/10.1021/jm050822c

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