Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Andreas Beier"'
Autor:
Michael Feichtinger, Andreas Beier, Mario Migotti, Matthias Schmid, Fedir Bokhovchuk, Patrick Chène, Robert Konrat
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104099- (2022)
Summary: Yes-associated protein (YAP) is a partly intrinsically disordered protein (IDP) that plays a major role as the downstream element of the Hippo pathway. Although the structures of the complex between TEA domain transcription factors (TEADs) a
Externí odkaz:
https://doaj.org/article/29d36cbaa80447f8b4aa1c02d947df57
Publikováno v:
Life, Vol 4, Iss 4, Pp 788-799 (2014)
Early-stage evolutionary development of the universal genetic code remains a fundamental, open problem. One of the possible scenarios suggests that the code evolved in response to direct interactions between peptides and RNA oligonucleotides in the p
Externí odkaz:
https://doaj.org/article/d95cb121ea924aa29d476d0b50c4dc1b
Autor:
Thomas C. Schwarz, Andreas Beier, Karin Ledolter, Thomas Gossenreiter, Theresa Höfurthner, Markus Hartl, Terry S. Baker, Richard J. Taylor, Robert Konrat
Publikováno v:
Proceedings of the National Academy of Sciences. 120
α-synuclein (αS) is an intrinsically disordered protein whose functional ambivalence and protein structural plasticity are iconic. Coordinated protein recruitment ensures proper vesicle dynamics at the synaptic cleft, while deregulated oligomerizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::793b349a66d829b7412cb2a0a7258412
https://doi.org/10.1073/pnas.2201910120
https://doi.org/10.1073/pnas.2201910120
Autor:
Roberta Pierattelli, Robert Konrat, Georg Kontaxis, Clara Conrad-Billroth, Isabella C. Felli, Borja Mateos, Andreas Beier, Marco Schiavina
Publikováno v:
Journal of Molecular Biology. 432:3093-3111
Intrinsically disordered proteins (IDPs) carry out many biological functions. They lack a stable three-dimensional structure, but rather adopt many different conformations in dynamic equilibrium. The interplay between local dynamics and global rearra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f5be1278f5eb5224a4ab0f80cfe53e
https://doi.org/10.1016/j.jmb.2019.11.015
https://doi.org/10.1016/j.jmb.2019.11.015
Autor:
Sven Brüschweiler, Robert Konrat, Julia Schörghuber, Darryl B. McConnell, Gerd Bader, Andreas Beier, Bernhard Wolkerstorfer, Leonhard Geist, Dirk Kessler, Harald Engelhardt, Moriz Mayer, Gerald Platzer, Julian E. Fuchs, Roman J. Lichtenecker
Publikováno v:
Angewandte Chemie (International Ed. in English)
While CH–π interactions with target proteins are crucial determinants for the affinity of arguably every drug molecule, no method exists to directly measure the strength of individual CH–π interactions in drug–protein complexes. Herein, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f4c4ecbf6441f842757fe25e95d829
https://pubmed.ncbi.nlm.nih.gov/32421895
https://pubmed.ncbi.nlm.nih.gov/32421895
Autor:
Thomas C. Schwarz, Robert Konrat, Gerald Platzer, Dennis Kurzbach, Andreas Beier, Francesca Tribuzio
Publikováno v:
Journal of Molecular Biology. 430:2439-2452
Molecular recognition of and by intrinsically disordered proteins (IDPs) is an intriguing and still largely elusive phenomenon. Typically, protein recognition involving IDPs requires either folding upon binding or, alternatively, the formation of "fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eba100fbe092931d55246f3ef06ec1c
https://doi.org/10.1016/j.jmb.2018.04.035
https://doi.org/10.1016/j.jmb.2018.04.035
Autor:
Theresa Höfurthner, Carmen Calvis, Andreas Beier, Robert Konrat, Santiago Esteban, Miguel Moreno, Laura Nevola, Michael Feichtinger, Ramon Messeguer
Publikováno v:
Cancer Research. 81:2471-2471
MYC is a transcription factor involved in fundamental cellular functions such as proliferation, apoptosis, differentiation, metabolism and, as lately discovered, immune response. [1,2] It is deregulated in a wide variety of aggressive human cancers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f4b198c1cd77b6b7dde6c775e20380
https://doi.org/10.1158/1538-7445.am2021-2471
https://doi.org/10.1158/1538-7445.am2021-2471
Autor:
Thomas C. Schwarz, Dennis Kurzbach, Robert Konrat, Agathe Vanas, Andrea G. Flamm, Andreas Beier, Gerald Platzer
Publikováno v:
Physical Chemistry Chemical Physics. 19:10651-10656
A novel statistical analysis of paramagnetic relaxation enhancement (PRE) and paramagnetic relaxation interference (PRI) based nuclear magnetic resonance (NMR) data is proposed based on the computation of correlation matrices. The technique is demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb45b2eb1e747efccf98c51e4a349a5
https://doi.org/10.1039/c7cp00430c
https://doi.org/10.1039/c7cp00430c
Autor:
Moriz Mayer, Roman J. Lichtenecker, Bernhard Wolkerstorfer, Sven Brüschweiler, Robert Konrat, Gerald Platzer, Julian E. Fuchs, Harald Engelhardt, Darryl B. McConnell, Julia Schörghuber, Gerd Bader, Leonhard Geist, Andreas Beier, Dirk Kessler
Publikováno v:
Angewandte Chemie. 132:14805-14805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa463c2ddf917cac66c36356be582a6
https://doi.org/10.1002/ange.202009454
https://doi.org/10.1002/ange.202009454
Autor:
Dirk Kessler, Robert Konrat, Bernhard Wolkerstorfer, Moriz Mayer, Harald Engelhardt, Roman J. Lichtenecker, Gerald Platzer, Julian E. Fuchs, Leonhard Geist, Julia Schörghuber, Sven Brüschweiler, Gerd Bader, Andreas Beier, Darryl B. McConnell
Publikováno v:
Angewandte Chemie International Edition. 59:14697-14697
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c68349f279ea8cb5df3e583149f6fec
https://doi.org/10.1002/anie.202009454
https://doi.org/10.1002/anie.202009454