Výsledky vyhledávání - "Andreas Baudy"

Akademický článek

Flow virometry for process monitoring of live virus vaccines-lessons learned from ERVEBO

Autor: Geoffri Ricci, Kevin Minsker, Austin Kapish, James Osborn, Sha Ha, Joseph Davide, Joseph P. Califano, Darrell Sehlin, Richard R. Rustandi, Lawrence W. Dick, Josef Vlasak, Timothy D. Culp, Andreas Baudy, Edward Bell, Malini Mukherjee

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Direct at line monitoring of live virus particles in commercial manufacturing of vaccines is challenging due to their small size. Detection of malformed or damaged virions with reduced potency is rate-limited by release potency assays with l

Externí odkaz: https://doaj.org/article/6fd2905286724233b97e09383c9378da

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A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery

Autor: James J. Monroe, Ian Knemeyer, Robert Houle, Andreas Baudy, Frank D. Sistare, Michael J. Hafey, Raymond Evers, Jackie Shang, Qing Chen, Keith Q. Tanis

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 48(11)

Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug-induced liver injury (DILI). To understand the relationship between BSEP inhibition and DIL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21253d6763d1c3e2f5fa4f7a61d5a63a
https://pubmed.ncbi.nlm.nih.gov/32943412

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Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

Autor: Adrian Roth, Douglas A. Keller, Philip Hewitt, Andreas Baudy, Terry R. Van Vleet, Radhakrishna Sura, Monicah A. Otieno, Jinping Gan, William R Proctor

Publikováno v: Lab on a chip. 20(2)

The liver is critical to consider during drug development because of its central role in the handling of xenobiotics, a process which often leads to localized and/or downstream tissue injury. Our ability to predict human clinical safety outcomes with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad20b0de1b57f15d2012f4870b6fafb
https://pubmed.ncbi.nlm.nih.gov/31799979

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Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury

Autor: Andreas Baudy, Manishkumar Patel, Paul D. Hockings, Daniel Scotcher, John C. Waterton, Aleksandra Galetin, J. Gerry Kenna, Gunnar Schuetz, Steven Sourbron, Catherine D. G. Hines, Sabina Ziemian

Publikováno v: Drug-Induced Liver Toxicity
Methods in Pharmacology and Toxicology ISBN: 9781493976768
Kenna, J G, Waterton, J C, Baudy, A, Galetin, A, Hines, C D G, Hockings, P, Patel, M, Scotcher, D, Sourbron, S, Ziemian, S & Schuetz, G 2018, Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury . in Drug-Induced Liver Toxicity . Methods in Pharmacology and Toxicology, no. 9781493976768, Humana Press, Inc, New York, NY, pp. 627-651 . https://doi.org/10.1007/978-1-4939-7677-5_30
Methods in Pharmacology and Toxicology
Methods in Pharmacology and Toxicology-Drug-Induced Liver Toxicity

Imaging technologies can evaluate many different biological processes in vitro (in cell culture models) and in vivo (in animals and humans), and many are used routinely in investigation of human liver diseases. Some of these methods can help understa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9d95eadbc9aaa8385974439dd215e6

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Pituitary adenylate cyclase-activating peptide (PACAP) induces differentiation in the neuronal F11 cell line through a PKA-dependent pathway

Autor: Andreas Baudy, John Dunlop, Kevin Pong, H. Beal McIlvain, Danni Liu, Kelly Sullivan, Myles Fennell

Publikováno v: Brain research. 1077(1)

PACAP is a peptide with neuroprotective activity, which induces adenylate cyclase and protein kinase A (PKA) activity. PACAP has also been shown to induce neurite outgrowth in PC12 cells and dorsal root ganglion (DRG) neurons. Here, we report that ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b54e32831c1f88e67fd413153fe1c1
https://pubmed.ncbi.nlm.nih.gov/16487495

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