Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andreas Børsting Jordy"'
Autor:
Lene Secher Myrmel, Anne-Marie Lundsgaard, Andreas Børsting Jordy, Jørgen F. P. Wojtaszewski, Lise Madsen, Henriette Pilegaard, Louise D. Høeg, Annette K. Serup, Erik A. Richter, Bente Kiens, Kim A. Sjøberg, Andreas M. Fritzen, Jacob Jeppesen
Publikováno v:
Diabetes. 66:2583-2595
To understand the mechanisms in lipid-induced insulin resistance, a more physiological approach is to enhance fatty acid (FA) availability through the diet. Nine healthy men ingested two hypercaloric diets (in 75% excess of habitual caloric intake) f
Autor:
Erik Christiansen, Astrid Breitschaft, Cilie W. Hansen, Tine A. Bækdal, Charlotte Granhall, Andreas Børsting Jordy, Azadeh Houshmand-Oregaard
Publikováno v:
Diabetes. 67
Semaglutide is a glucagon-like peptide (GLP-1) analog co-formulated with the absorption enhancer, sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC), to allow oral administration. The effect of oral semaglutide on the pharmacokinetics (PK) of the
Autor:
Jørgen F. P. Wojtaszewski, Thomas Larsen, Arne Astrup, Anne-Marie Lundsgaard, Steen Stender, Henriette Pilegaard, Erik A. Richter, Bente Kiens, Sanne Kellebjerg Poulsen, Andreas Børsting Jordy, Andreas M. Fritzen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:3509-3519
The molecular mechanisms behind diet-induced metabolic improvements remain to be studied.This study sought to investigate whether expression of proteins in skeletal muscle or adipose tissue could explain improvements in glucose and lipid homeostasis
Autor:
Bente Kiens, Andreas Børsting Jordy
Publikováno v:
Experimental Physiology. 99:1586-1592
New Findings What is the topic of this review? This report addresses novel mechanisms regulating the utilization of long-chain fatty acids, with emphasis on FAT/CD36 and lipolysis of intramuscular triacylglycerol in skeletal muscle during exercise an
Autor:
Lykke Sylow, Anne-Julie Oxboll, David E. James, Andreas Børsting Jordy, Daniel J. Fazakerley, Markus A. Rüegg, Kristen C. Thomas, James R. Krycer, Thomas E. Jensen, Guang Yang, Maximilian Kleinert, Peter Schjerling, Erik A. Richter, Bente Kiens
Publikováno v:
Molecular Metabolism
The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistance in mice, whereas the mTORC1
Autor:
Jacob Jeppesen, Annette K. Serup, David M. Thomson, Niels Jessen, Klaus Qvortrup, Roger W. Hunter, Kasper Thorsen, Andreas Børsting Jordy, Kei Sakamoto, Christian Pehmøller, Jason R.B. Dyck, Clara Prats, Lykke Sylow, Stine J. Maarbjerg, Andreas M. Fritzen, Peter Schjerling, Erik A. Richter, Bente Kiens, Jørgen F. P. Wojtaszewski
Publikováno v:
Diabetes
Jeppesen, J F, Maarbjerg, S J, Jordy, A B, Fritzen, A M, Pehmøller, C K, Hansen, L S, Serup, A K L, Jessen, N, Thorsen, K, Prats, C, Qvortrup, K, Dyck, J R B, Hunter, R W, Sakamoto, K, Thomson, D M, Schjerling, P, Wojtaszewski, J, Richter, E & Kiens, B 2013, ' LKB1 regulates lipid oxidation during exercise independently of AMPK ', Diabetes, vol. 62, no. 5, pp. 1490-9 . https://doi.org/10.2337/db12-1160
Jeppesen, J F, Maarbjerg, S J, Jordy, A B, Fritzen, A M, Pehmøller, C K, Hansen, L S, Serup, A K L, Jessen, N, Thorsen, K, Prats, C, Qvortrup, K, Dyck, J R B, Hunter, R W, Sakamoto, K, Thomson, D M, Schjerling, P, Wojtaszewski, J, Richter, E & Kiens, B 2013, ' LKB1 regulates lipid oxidation during exercise independently of AMPK ', Diabetes, vol. 62, no. 5, pp. 1490-9 . https://doi.org/10.2337/db12-1160
Lipid metabolism is important for health and insulin action, yet the fundamental process of regulating lipid metabolism during muscle contraction is incompletely understood. Here, we show that liver kinase B1 (LKB1) muscle-specific knockout (LKB1 MKO
Autor:
Anne-Marie Lundsgaard, Erik A. Richter, Bente Kiens, Andreas Børsting Jordy, Kim A. Sjøberg, Jørgen F. P. Wojtaszewski, Louise D. Høeg, Natalie Hiscock
Publikováno v:
Journal of Applied Physiology. 114:592-601
Adiponectin is an adipokine that regulates metabolism and increases insulin sensitivity. Mechanisms behind this insulin-sensitizing effect have been investigated in rodents, but little is known in humans, especially in skeletal muscle. Women have hig
Autor:
Cecilia Holm, Thomas J. Alsted, Andreas Børsting Jordy, Annette K. Serup, Bente Kiens, Peter Schjerling
Publikováno v:
Diabetes. 65(10)
Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appe
Autor:
Jesper B. Birk, Niels Jessen, Benoit Viollet, Rasmus Kjøbsted, Kasper Thorsen, Andreas Børsting Jordy, Jørgen F. P. Wojtaszewski, Jacob Jeppesen, Joachim Fentz, Peter Schjerling, Bente Kiens
Publikováno v:
Fentz, J, Kjøbsted, R, Birk, J B, Jordy, A B, Jeppesen, J, Thorsen, K, Schjerling, P, Kiens, B, Jessen, N, Viollet, B & Wojtaszewski, J F P 2015, ' AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice ', F A S E B Journal, vol. 29, no. 5, pp. 1725-1738 . https://doi.org/10.1096/fj.14-266650
The importance of AMPK in regulation of fatty acid (FA) oxidation in skeletal muscle with contraction/exercise is unresolved. Using a mouse model lacking both AMPKα1 and -α2 in skeletal muscle specifically (mdKO), we hypothesized that FA utilizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee194faf5bacf98658b54d3194a57169
https://pure.au.dk/portal/da/publications/ampk-is-critical-for-enhancing-skeletal-muscle-fatty-acid-utilization-during-in-vivo-exercise-in-mice(3f4a1de1-3690-4031-b247-4d31c64b31da).html
https://pure.au.dk/portal/da/publications/ampk-is-critical-for-enhancing-skeletal-muscle-fatty-acid-utilization-during-in-vivo-exercise-in-mice(3f4a1de1-3690-4031-b247-4d31c64b31da).html
Autor:
Mark A. Febbraio, Helene L. Kammoun, Michael J Kraakman, Timothy Gardner, Andreas Børsting Jordy, Emma Estevez, Bente Kiens, Darren C. Henstridge, Peter J. Meikle, Jacqui M Weir
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 308(9)
The accumulation of lipid at ectopic sites, including the skeletal muscle and liver, is a common consequence of obesity and is associated with tissue-specific and whole body insulin resistance. Exercise is well known to improve insulin resistance by