Výsledky vyhledávání - "Andreas Bøggild"

Akademický článek

Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles

Autor: Ian Helstrup Nielsen, Anne Bruun Rovsing, Jacob Hørlück Janns, Emil Aagaard Thomsen, Albert Ruzo, Andreas Bøggild, Frederikke Nedergaard, Charlotte Thornild Møller, Thomas Boesen, Søren Egedal Degn, Jagesh V. Shah, Jacob Giehm Mikkelsen

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102318- (2024)

To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of engineered lentivirus-derived nanoparticles (LVNPs), we demonstrate efficient cell-targeted deliv

Externí odkaz: https://doaj.org/article/5b0da4b8e2504d17b7dca8efcfd345d5

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Akademický článek

The Cell Envelope Structure of Cable Bacteria

Autor: Rob Cornelissen, Andreas Bøggild, Raghavendran Thiruvallur Eachambadi, Roman I. Koning, Anna Kremer, Silvia Hidalgo-Martinez, Eva-Maria Zetsche, Lars R. Damgaard, Robin Bonné, Jeroen Drijkoningen, Jeanine S. Geelhoed, Thomas Boesen, Henricus T. S. Boschker, Roland Valcke, Lars Peter Nielsen, Jan D'Haen, Jean V. Manca, Filip J. R. Meysman

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Cable bacteria are long, multicellular micro-organisms that are capable of transporting electrons from cell to cell along the longitudinal axis of their centimeter-long filaments. The conductive structures that mediate this long-distance electron tra

Externí odkaz: https://doaj.org/article/111009a38e7a4b598145f7d94f4cc993

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Comparative electric and ultrastructural studies of cable bacteria reveal new components of conduction machinery

Autor: Leonid Digel, Mads L. Justesen, Robin Bonné, Nico Fransaert, Koen Wouters, Pia B. Jensen, Lea E. Plum-Jensen, Ian P. G. Marshall, Louison Nicolas-Asselineau, Taner Drace, Andreas Bøggild, John L. Hansen, Andreas Schramm, Espen D. Bøjesen, Lars P. Nielsen, Jean V. Manca, Thomas Boesen

Cable bacteria encompass at least two genera, and they are known to vary greatly in habitat preferences and filament thickness. We systematically investigated variations and similarities in cellular structures and electrical properties of different c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::039223ec8595fdb10dbfb9a87416a6aa
https://doi.org/10.1101/2023.05.24.541955

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Structure, folding and flexibility of co-transcriptional RNA origami

Autor: Ewan K. S. McRae, Helena Østergaard Rasmussen, Jianfang Liu, Andreas Bøggild, Michael T. A. Nguyen, Nestor Sampedro Vallina, Thomas Boesen, Jan Skov Pedersen, Gang Ren, Cody Geary, Ebbe Sloth Andersen

Publikováno v: Nature nanotechnology, vol 18, iss 7
McRae, E K S, Rasmussen, H Ø, Liu, J, Bøggild, A, Nguyen, M T A, Sampedro Vallina, N, Boesen, T, Pedersen, J S, Ren, G, Geary, C & Andersen, E S 2023, ' Structure, folding and flexibility of co-transcriptional RNA origami ', Nature Nanotechnology . https://doi.org/10.1038/s41565-023-01321-6

RNA origami is a method for designing RNA nanostructures that can self-assemble through co-transcriptional folding with applications in nanomedicine and synthetic biology. However, to advance the method further, an improved understanding of RNA struc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db776adc6c7ddd32d8dda4942734fbc1
https://doi.org/10.1038/s41565-023-01321-6

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High-resolution structures and conformational dynamics of RNA origami during folding

Autor: Ebbe Andersen, Ewan McRae, Helena Rasmussen, Jianfang Liu, Andreas Bøggild, Michael Nguyen, Nestor Vallina, Thomas Boesen, Jan Skov Pedersen, Gang (Gary) Ren, Cody Geary

Cotranscriptional folding of RNA is a fundamental self-assembly process of nature, important for the biological assembly of complex molecular machines like the ribosome. Inspired by this folding process, we developed the cotranscriptional RNA origami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3183f52ad0c7adb90b7b8a083d9e53e5
https://doi.org/10.21203/rs.3.rs-1182359/v1

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Predicted Loop Regions Promote Aggregation: A Study of Amyloidogenic Domains in the Functional Amyloid FapC

Autor: Brian S. Vad, Jan Skov Pedersen, Andreas Bøggild, Madhu Nagaraj, Mumdooh Ahmed, Jeppe Lyngsø, Anne Fillipsen, Daniel E. Otzen, Ümit Akbey

Publikováno v: Nagaraj, M, Ahmed, M, Lyngsø, J, Vad, B S, Bøggild, A, Fillipsen, A, Pedersen, J S, Otzen, D E & Akbey, Ü 2020, ' Predicted Loop Regions Promote Aggregation : A Study of Amyloidogenic Domains in the Functional Amyloid FapC ', Journal of Molecular Biology, vol. 432, no. 7, pp. 2232-2252 . https://doi.org/10.1016/j.jmb.2020.01.044

Protein fibrillation is traditionally associated with misfolding, loss of functional phenotype, and gain of toxicity in neurodegenerative diseases. However, many organisms exploit fibrils in the form of functional amyloids (FA), as seen in bacteria,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0f60043b5fcda772fa980ff6e8364c
https://doi.org/10.1016/j.jmb.2020.01.044

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How to grow your cable bacteria: Establishment of a stable single-strain culture in sediment and proposal of Candidatus Electronema aureum GS

Autor: Lars Peter Nielsen, Jesper Jensen Bjerg, Caitlin Petro, Casper Thorup, Signe Brokjær, Andreas Bøggild, Tine Sneibjerg Ebsen, Andreas Schramm

Publikováno v: Thorup, C, Petro, C, Bøggild, A, Ebsen, T S, Brokjær, S, Nielsen, L P, Schramm, A & Bjerg, J J 2021, ' How to grow your cable bacteria : Establishment of a stable single-strain culture in sediment and proposal of Candidatus Electronema aureum GS ', Systematic and Applied Microbiology, vol. 44, no. 5, 126236 . https://doi.org/10.1016/j.syapm.2021.126236
Systematic and applied microbiology

Cable bacteria are multicellular filamentous bacteria within the Desulfobulbaceae that couple the oxidation of sulfide to the reduction of oxygen over centimeter distances via long distance electron transport (LDET). So far, none of the freshwater or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff97c97cf541d5f5f11451e364cbe914
https://doi.org/10.1016/j.syapm.2021.126236

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On the evolution and physiology of cable bacteria

Autor: Markus Schmid, Tingting Yang, Lars Peter Nielsen, Thomas Boesen, Michael Wagner, Morten Simonsen Dueholm, Andreas Bøggild, Jesper Tataru Bjerg, Kasper Urup Kjeldsen, Marta Nierychlo, Per Halkjær Nielsen, Jeanine S. Geelhoed, Andreas Schramm, Lars Schreiber, Casper Thorup, Steffen Larsen, Filip J. R. Meysman, Jack van de Vossenberg, Nils Risgaard-Petersen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Kjeldsen, K U, Schreiber, L, Thorup, C A, Boesen, T, Bjerg, J T, Yang, T, Dueholm, M S, Larsen, S, Risgaard-Petersen, N, Nierychlo, M, Schmid, M, Bøggild, A, Vossenberg, J V D, Geelhoed, J S, Meysman, F J R, Wagner, M, Nielsen, P H, Nielsen, L P & Schramm, A 2019, ' On the evolution and physiology of cable bacteria ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 38, pp. 19116-19125 . https://doi.org/10.1073/pnas.1903514116
Kjeldsen, K U, Schreiber, L, Thorup, C A, Boesen, T, Bjerg, J T, Yang, T, Dueholm, M S, Larsen, S, Risgaard-Petersen, N, Nierychlo, M, Schmid, M, Bøggild, A, van de Vossenberg, J, Geelhoed, J S, Meysman, F J R, Wagner, M, Nielsen, P H, Nielsen, L P & Schramm, A 2019, ' On the evolution and physiology of cable bacteria ', Proceedings of the National Academy of Sciences, vol. 116, no. 38, pp. 19116-19125 . https://doi.org/10.1073/pnas.1903514116

Cable bacteria of the family Desulfobulbaceae form centimeter-long filaments comprising thousands of cells. They occur worldwide in the surface of aquatic sediments, where they connect sulfide oxidation with oxygen or nitrate reduction via long-dista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bdcc826126cae1941ef6e7fc56fa3e
https://repository.uantwerpen.be/docman/irua/52d568/162785_2020_03_17.pdf

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The Tubular Sheaths Encasing Methanosaeta thermophila Filaments Are Functional Amyloids

Autor: Gunna Christiansen, Poul Larsen, Andreas Bøggild, Per Halkjær Nielsen, Marcel Stenvang, Daniel E. Otzen, Kai Finster, Morten Simonsen Dueholm, Brian S. Vad

Publikováno v: Dueholm, M S, Larsen, P, Finster, K, Stenvang, M R, Christiansen, G, Vad, B S, Bøggild, A, Otzen, D E & Nielsen, P H 2015, ' The Tubular Sheaths Encasing Methanosaeta thermophila Filaments Are Functional Amyloids ', Journal of Biological Chemistry, vol. 290, no. 33, pp. 20590-20600 . https://doi.org/10.1074/jbc.M115.654780
Dueholm, M S, Larsen, P, Finster, K, Stenvang, M R, Christiansen, G, Vad, B S, Bøggild, A, Otzen, D E & Halkjær Nielsen, P 2015, ' The Tubular Sheaths Encasing Methanosaeta thermophila Filaments are Functional Amyloids ', Journal of Biological Chemistry, vol. 290, pp. 20590-26600 . https://doi.org/10.1074/jbc.M115.654780

Archaea are renowned for their ability to thrive in extreme environments, although they can be found in virtually all habitats. Their adaptive success is linked to their unique cell envelopes that are extremely resistant to chemical and thermal denat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdcc273235335ded00d7413af004b37
https://doi.org/10.1074/jbc.m115.654780

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