Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases

Autor: Kushtrim Kryeziu, Seyed H. Moosavi, Christian H. Bergsland, Marianne G. Guren, Peter W. Eide, Max Z. Totland, Kristoffer Lassen, Andreas Abildgaard, Arild Nesbakken, Anita Sveen, Ragnhild A. Lothe

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-11 (2021)

Abstract Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses ex vivo and offer an opportunity

Externí odkaz: https://doaj.org/article/ae8e4589a2914bc0acf2c8d31711cf45

Laparoscopic Resection of Recurrence from Hepatocellular Carcinoma after Liver Transplantation: Case Reports and Review of the Literature

Autor: Mushegh A. Sahakyan, Airazat M. Kazaryan, Ewa Pomianowska, Andreas Abildgaard, Pål-Dag Line, Bjørn Atle Bjørnbeth, Bjørn Edwin, Bård Ingvald Røsok

Publikováno v: Case Reports in Oncological Medicine, Vol 2016 (2016)

Background. Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) indicates a poor prognosis. Surgery is considered the only curative option for selected patients with HCC recurrence following LT. Traditionally, the preference

Externí odkaz: https://doaj.org/article/ceeb8c4dc0794f3abb6adaa35e7f18df

Investigating Particle Size Effects in Catalysis by Applying a Size-Controlled and Surfactant-Free Synthesis of Colloidal Nanoparticles in Alkaline Ethylene Glycol: Case Study of the Oxygen Reduction Reaction on Pt

Autor: Masanori Inaba, Mehtap Oezaslan, Matthias Arenz, Jan Bucher, Søren Bredmose Simonsen, Andreas Abildgaard Swane, Jonathan Quinson, Kirsten M. Ø. Jensen, Jacob J. K. Kirkensgaard, Sebastian Kunz, Luise Theil Kuhn, Sarah Neumann

Publikováno v: ACS Catalysis
Quinson, J, Inaba, M, Neumann, S, Swane, A A, Bucher, J, Simonsen, S B, Theil Kuhn, L, Kirkensgaard, J J K, Jensen, K M O, Oezaslan, M, Kunz, S & Arenz, M 2018, ' Investigating particle size effects in catalysis by applying a size controlled and surfactant-free synthesis of colloidal nanoparticles in alkaline ethylene glycol-The case study of the oxygen reduction reaction on Pt ', A C S Catalysis, vol. 8, pp. 6627-6635 . https://doi.org/10.1021/acscatal.8b00694
ACS catalysis 8(7), 6627-6635 (2018). doi:10.1021/acscatal.8b00694

Colloidal platinum nanoparticles are obtained via a surfactant-free polyol process in alkaline ethylene glycol. In this popular synthesis, ethylene glycol functions as solvent and reducing agent. The preparation procedure is known for its reproducibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf408a5cecb9b076ea1b862123eb31f6
https://doi.org/10.1021/acscatal.8b00694

Abstract A19: Modeling intrapatient pharmacotranscriptomic heterogeneity with organoids derived from colorectal cancer liver metastases

Autor: Tuva Høst Brunsell, Jarle Bruun, Bjørn Atle Bjørnbeth, Kushtrim Kryeziu, Arild Nesbakken, Ragnhild A. Lothe, Jonas Langerud, Ina A. Eilertsen, Marianne Grønlie Guren, Andreas Abildgaard, Peter W. Eide, Bård I. Røsok, Anita Sveen, Seyed H. Moosavi

Publikováno v: Cancer Research. 80:A19-A19

Patients with metastatic colorectal cancer (CRC) have few targeted treatment options compared with other major malignancies, and both over- and undertreatment with cytostatic drugs remain a challenge. Recent studies show that patient-derived organoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::485b8e3cc6ddc481497723818f93835a
https://doi.org/10.1158/1538-7445.camodels2020-a19

The predictive value of coronary artery calcium detected by computed tomography in a prospective study on cardiac allograft vasculopathy in heart transplant patients

Autor: Thor Edvardsen, Leiv Sandvik, Einar Gude, Jarl Å. Jakobsen, Lars Aaberge, Andreas Abildgaard, Lars Gullestad, Anne Günther, Rune Andersen

Publikováno v: Transplant International. 31:82-91

The predictive value of coronary artery calcium (CAC) in heart transplant (HTX) patients is not established. We explored if the absence of CAC on computed tomography (CT) could exclude moderate and severe cardiac allograft vasculopathy [CAV2-3 ; the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efed380e8b525ebfd27630d8762e9e
https://doi.org/10.1111/tri.13057