Výsledky vyhledávání - "Andreas Janzer"

Akademický článek

Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation

Autor: Zhe Ji, Lizhi He, Asaf Rotem, Andreas Janzer, Christine S. Cheng, Aviv Regev, Kevin Struhl

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Systematic analysis of the control of dynamic cellular processes remains a challenge. Here the authors introduce a pipeline enabling them to identify TFs involved in Src-induced cellular transformation, and find that a large number of TFs with divers

Externí odkaz: https://doaj.org/article/290b03e8292f4574bc8968e5aeb70019

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De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

SUMMARYMutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they appear less active in aggressive glioma, underscoring the need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef99b65b0828b3d636a1f8cfa0b31ac5
https://doi.org/10.1101/2021.11.30.470443

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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

Autor: Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, Joyce H. Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy B. Cameron, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y.R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin, Samuel K. McBrayer

Publikováno v: Cancer Cell. 40:939-956.e16

Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they seem to be less active in aggressive glioma, underscoring the need fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8efc2185c0705640ff71c554ff4fe6
https://doi.org/10.1016/j.ccell.2022.07.011

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Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation

Autor: Asaf Rotem, Zhe Ji, Aviv Regev, Lizhi He, Kevin Struhl, Andreas Janzer, Christine S. Cheng

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature

Transient activation of Src oncoprotein in non-transformed, breast epithelial cells can initiate an epigenetic switch to the stably transformed state via a positive feedback loop that involves the inflammatory transcription factors STAT3 and NF-κB.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780d85d0c75304dd1a117efe04c05dc2
http://link.springer.com/article/10.1038/s41467-018-04406-2

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DDRE-29. DE NOVO PYRIMIDINE SYNTHESIS IS A TARGETABLE VULNERABILITY IN IDH-MUTANT GLIOMA

Publikováno v: Neuro-oncology Advances

70–90% of lower-grade gliomas and secondary glioblastomas harbor gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1), causing overproduction of the oncometabolite (R)-2-hydroxyglutarate [(R)-2HG]. Although inhibitors of mutant IDH enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c10160a44ca8baa2c38c07d960be79
http://europepmc.org/articles/PMC7992238

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Abstract 2077: Activity of DHODH inhibitor BAY2402234 in subcutaneous and intracranial models of SCLC

Autor: Ricarda Schlenz, Stefan Kaulfuss, Renan Borowicz, Andreas Janzer, Andrea Triller, Gerhard Siemeister, Sven Christian, Katrin Gutberlet, Ashley Eheim, Katrin Jaensch, Michael Jeffers

Publikováno v: Cancer Research. 81:2077-2077

Introduction: BAY2402234 is a potent and specific orally administered inhibitor of dihydroorotate dehydrogenase (DHODH) which showed anti-tumor activity in preclinical models of AML and is under clinical evaluation in myeloid malignancies (NCT0340472

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4400e0b2c5fe6a2eaf5534efe06d32b0
https://doi.org/10.1158/1538-7445.am2021-2077

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Abstract DDT02-04: BAY 2402234: A novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies

Publikováno v: Cancer Research. 78:DDT02-04

Acute myeloid leukemia (AML), the most common acute leukemia in adults, is an aggressive hematologic malignancy resulting in bone marrow failure with a poor outcome; overall survival is approximately 25% at five years. Treatment options, in particula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::810e228e308047a51f2ef7b9122f3063
https://doi.org/10.1158/1538-7445.am2018-ddt02-04

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Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts

Autor: Roland Schüle, Magdalena Rohde, Andreas Janzer, Jutta Kirfel, Dominica Willmann, Hubert Schorle, Angela Egert, Elisabeth Sievers

Publikováno v: Experimental Cell Research. 348:123-131

Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing, immune responses and invasive tumors all require the orchestrated movement of cells to sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0029114a86485eadfdb331d3b01513c
https://doi.org/10.1016/j.yexcr.2016.08.026

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The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

Publikováno v: Leukemia. 33(10)

Acute myeloid leukemia (AML) is a devastating disease, with the majority of patients dying within a year of diagnosis. For patients with relapsed/refractory AML, the prognosis is particularly poor with currently available treatments. Although genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb03783633912c9af747df44438ccf9c
https://pubmed.ncbi.nlm.nih.gov/30940908

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Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

Autor: Benjamin Izar, Levi A. Garraway, Andreas Janzer, Kevin Struhl, John G. Doench, Asaf Rotem, Zhe Ji

Publikováno v: Proceedings of the National Academy of Sciences. 112:5708-5713

Colony formation in soft agar is the gold-standard assay for cellular transformation in vitro, but it is unsuited for high-throughput screening. Here, we describe an assay for cellular transformation that involves growth in low attachment (GILA) cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc4b16e4756b8e0947b4ba7a0384fc2
https://doi.org/10.1073/pnas.1505979112

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