Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Andreas Gaumann"'
Autor:
Barbara Schwertner, George Dahdal, Wolfgang Jagla, Luis Grossmann, Konstantin Drexler, Michael P. Krahn, Katja Evert, Mark Berneburg, Sebastian Haferkamp, Christine Ziegler, Eric K. Parkinson, Grit Zahn, Maria E. Mycielska, Andreas Gaumann
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
We have recently shown that cancer cells of various origins take up extracellular citrate through the plasma membrane citrate carrier (pmCiC), a specific plasma membrane citrate transporter. Extracellular citrate is required to support cancer cell me
Externí odkaz:
https://doaj.org/article/0e8a6ba44376475d8a649d023b9f0b09
Autor:
Louisa Hempel, Constantin Lapa, Alexander Dierks, Andreas Gaumann, Josef Scheiber, Julia Veloso de Oliveira, Patrick Philipp, Cristina Oyarzun Laura, Stefan Wesarg, Sebastian Robert, Dirk Hempel
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Point mutations of the fibroblast growth factor receptor (FGFR)2 receptor in intrahepatic cholangiocarcinoma (iCC) are mainly of unknown functional significance compared to FGFR2 fusions. Pemigatinib, a tyrosine kinase inhibitor, is approved for the
Externí odkaz:
https://doaj.org/article/982c38906143430eb4ee3583f4e9e6bd
Autor:
Axel Muendlein, Kathrin Geiger, Stella Gaenger, Tobias Dechow, Christoph Nonnenbroich, Andreas Leiherer, Heinz Drexel, Andreas Gaumann, Wolfgang Jagla, Thomas Winder, Frank Mayer, Thomas Decker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Mutational analysis of circulating tumour (ct) DNA holds promise as an effective tool to predict the course of metastatic breast cancer (MBC). In the present study we used targeted next generation sequencing of ctDNA to evaluate the impact o
Externí odkaz:
https://doaj.org/article/37dd500e40fe4840b82c9e036d120298
Autor:
Sebastian Haferkamp, Konstantin Drexler, Marianne Federlin, Hans J. Schlitt, Mark Berneburg, Jerzy Adamski, Andreas Gaumann, Edward K. Geissler, Vadivel Ganapathy, E. Kenneth Parkinson, Maria E. Mycielska
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cancer cells need excess energy and essential nutrients/metabolites not only to divide and proliferate but also to migrate and invade distant organs for metastasis. Fatty acid and cholesterol synthesis, considered a hallmark of cancer for anabolism a
Externí odkaz:
https://doaj.org/article/c535675aec8b489abe46ee49c300d3a5
Autor:
Maria E. Mycielska, Markus T. J. Mohr, Katharina Schmidt, Konstantin Drexler, Petra Rümmele, Sebastian Haferkamp, Hans J. Schlitt, Andreas Gaumann, Jerzy Adamski, Edward K. Geissler
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decr
Externí odkaz:
https://doaj.org/article/94167722af1242ae8c4c8509999316e3
Autor:
Evan H Stanton, Konstantin Drexler, Sebastian Haferkamp, Marianne Federlin, Jerzy Adamski, Wolfgang Buchalla, Andreas Gaumann, Maria E. Mycielska, Vladimir M. Milenkovic, Katrin Jordan, Martin Proescholdt, Edward K. Geissler
Publikováno v:
Current Molecular Medicine. 22:506-513
Abstract: Brain tissue is known to have elevated citrate levels, necessary to regulate ion chelation, neuron excitability, and are also necessary for the supply of necessary energy substrates to neurons. Importantly, citrate also acts as a central su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75af442b579cf710dc2dce5e8af3bf22
https://doi.org/10.2174/1566524021666210302143802
https://doi.org/10.2174/1566524021666210302143802
Autor:
Frank R. De Gruijl, Edward K. Geissler, Rein Willemze, Jan N. Bouwes Bavinck, Cornelis P. Tensen, Abdoel El Ghalbzouri, Andreas Gaumann, Marjolein G.E. Van Olderen, Heggert G. Rebel, Gudrun E Koehl, Carolien A Bodmann, Pieter Voskamp
PDF file - 67K, Supplementary table 1; Primer sequences. Supplementary figure 1; Effects of immunosuppressive drugs on epidermal proliferation in HSEs (n=3-4) as % of Ki-67 positive (supra-)basal cells. Supplementary figure 2: Mice on Aza diet (A) sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a5e39ede1729a72d0a23e474160257
https://doi.org/10.1158/1940-6207.22524020.v1
https://doi.org/10.1158/1940-6207.22524020.v1
Autor:
Oliver Stoeltzing, Edward K. Geissler, Hans J. Schlitt, David Batt, Andreas Gaumann, Christina Hackl, Akira Mori, Christian Moser, Philipp Schachtschneider, Sven A. Lang
Supplementary Fig. S1 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72602e2e3037c0e98d118eddb7291119
https://doi.org/10.1158/1535-7163.22483097.v1
https://doi.org/10.1158/1535-7163.22483097.v1
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
Krebs cycle activity in the presence of extracellular citrate and absolute citrate levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33562ad332dd0da3e0d23cbf15bbe656
https://doi.org/10.1158/0008-5472.22419494.v1
https://doi.org/10.1158/0008-5472.22419494.v1
Autor:
Oliver Stoeltzing, Edward K. Geissler, Hans J. Schlitt, David Batt, Andreas Gaumann, Christina Hackl, Akira Mori, Christian Moser, Philipp Schachtschneider, Sven A. Lang
The Ras/Raf/MEK pathway represents an important oncogenic signaling pathway in gastrointestinal malignancies, including pancreatic cancer. Although activating B-Raf mutations are infrequent in pancreatic cancer, we hypothesized that targeting Raf cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107e50c1e4608618ad022f4a02cf96c1
https://doi.org/10.1158/1535-7163.c.6531068
https://doi.org/10.1158/1535-7163.c.6531068