Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Andreas, Villunger"'
Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity
Autor:
Marina A. Schapfl, Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai, Michelle S. Levine, Eva Kiermaier, Verena Labi, Andrew J. Holland, Andreas Villunger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Centrioles define centrosome structure and function. Deregulation of centriole numbers can cause developmental defects and cancer. The p53 tumor suppressor limits the growth of cells lacking or harboring additional centrosomes and can be eng
Externí odkaz:
https://doaj.org/article/019d4fb19cb64cd6834d48d84c0fafe0
Autor:
Maja Zupančič, Erik Keimpema, Evgenii O. Tretiakov, Stephanie J. Eder, Itamar Lev, Lukas Englmaier, Pradeep Bhandari, Simone A. Fietz, Wolfgang Härtig, Estelle Renaux, Andreas Villunger, Tomas Hökfelt, Manuel Zimmer, Frédéric Clotman, Tibor Harkany
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Acquisition of specialized cellular features is controlled by the ordered expression of transcription factors (TFs) along differentiation trajectories. Here, we find a member of the Onecut TF family, ONECUT3, expressed in postmitotic neurons
Externí odkaz:
https://doaj.org/article/870efa62a88f49e8b3dc3aa88928feec
Autor:
Jana Trifinopoulos, Julia List, Thorsten Klampfl, Klara Klein, Michaela Prchal-Murphy, Agnieszka Witalisz-Siepracka, Florian Bellutti, Luca L. Fava, Gerwin Heller, Sarah Stummer, Patricia Testori, Monique L. den Boer, Judith M. Boer, Sonja Marinovic, Gregor Hoermann, Wencke Walter, Andreas Villunger, Piotr Sicinski, Veronika Sexl, Dagmar Gotthardt
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cancer research
Externí odkaz:
https://doaj.org/article/8800b97f24a34ac584683af5d6db62a8
Autor:
Michael Lohmüller, Bernhard F. Roeck, Tamas G. Szabo, Marina A. Schapfl, Fragka Pegka, Sebastian Herzog, Andreas Villunger, Fabian Schuler
Publikováno v:
Molecular Oncology, Vol 16, Iss 15, Pp 2771-2787 (2022)
Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of under‐replicated DNA or exogenous DNA damage. Cancer cells deficient in p53 tumor suppressor func
Externí odkaz:
https://doaj.org/article/813987d97eda4623b0c6dc51025a7d5f
Autor:
Gerlinde Karbon, Manuel D. Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl, Andreas Villunger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Abstract Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mi
Externí odkaz:
https://doaj.org/article/be72c07d709a45b1826c65c6dd5e8661
Autor:
Katharina Hutter, Thomas Rülicke, Tamas G. Szabo, Lill Andersen, Andreas Villunger, Sebastian Herzog
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
MicroRNAs are small non-coding RNAs that have emerged as post-transcriptional regulators involved in development and function of different types of immune cells, and aberrant miRNA expression has often been linked to cancer. One prominent miRNA famil
Externí odkaz:
https://doaj.org/article/d7203d1cea344819b421c719e24a2b13
Autor:
Taimoor I. Sheikh, Nasim Vasli, Stephen Pastore, Kimia Kharizi, Ricardo Harripaul, Zohreh Fattahi, Shruti Pande, Farooq Naeem, Abrar Hussain, Asif Mir, Omar Islam, Katta Mohan Girisha, Muhammad Irfan, Muhammad Ayub, Christoph Schwarzer, Hossein Najmabadi, Anju Shukla, Valentina C. Sladky, Vincent Zoran Braun, Irmina Garcia-Carpio, Andreas Villunger, John B. Vincent
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract PIDD1 encodes p53-Induced Death Domain protein 1, which acts as a sensor surveilling centrosome numbers and p53 activity in mammalian cells. Early results also suggest a role in DNA damage response where PIDD1 may act as a cell-fate switch,
Externí odkaz:
https://doaj.org/article/59946732b5df4eecace75327ea1e1e2b
Autor:
Leonie Meyer-Heemsoth, Katja Mitschke, Jasmina Bier, Konstantin Schütz, Andreas Villunger, Tobias J. Legler, Martin S. Weber, Fred Lühder, Holger M. Reichardt
Publikováno v:
Cells, Vol 12, Iss 3, p 450 (2023)
Glucocorticoids (GCs) are used to treat inflammatory disorders such as multiple sclerosis (MS) by exerting prominent activities in T cells including apoptosis induction and suppression of cytokine production. However, little is known about their impa
Externí odkaz:
https://doaj.org/article/7aa68e66f5924d57a5e3dda753c2a6fd
Publikováno v:
Cells, Vol 11, Iss 14, p 2126 (2022)
Glucocorticoids (GC) are highly potent negative regulators of immune and inflammatory responses. Effects of GC are primarily mediated by the glucocorticoid receptor (GR) which is expressed by all cell types of the immune system. It is, therefore, dif
Externí odkaz:
https://doaj.org/article/0e4f270e9c844f80bc80b0b14480c01a
Autor:
Chiara Herzog, Charlotte D. Vavourakis, James E. Barrett, Gerlinde Karbon, Andreas Villunger, Jiangrong Wang, Karin Sundström, Joakim Dillner, Martin Widschwendter
Publikováno v:
International Journal of Cancer. 152:2321-2330