Zobrazeno 1 - 10
of 590
pro vyhledávání: '"Andreas, Strasser"'
Autor:
Cindy Audiger, Yacine Laâbi, Junli Nie, Leonie Gibson, Julie Wilson-Annan, Phillip Brook-Carter, Andrew Kueh, Alan W. Harris, Shalin Naik, Stephen L. Nutt, Andreas Strasser, Jerry M. Adams, Philippe Bouillet, Michaël Chopin
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114159- (2024)
Summary: The traditional view of hematopoiesis is that myeloid cells derive from a common myeloid progenitor (CMP), whereas all lymphoid cell populations, including B, T, and natural killer (NK) cells and possibly plasmacytoid dendritic cells (pDCs),
Externí odkaz:
https://doaj.org/article/c89909ecc3fe477ea2e87a7d2dff8850
Autor:
Destiny Dalseno, Holly Anderton, Andrew Kueh, Marco J Herold, John Silke, Andreas Strasser, Philippe Bouillet
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-9 (2023)
Abstract The cytokine TNF has essential roles in immune defence against diverse pathogens and, when its expression is deregulated, it can drive severe inflammatory disease. The control of TNF levels is therefore critical for normal functioning of the
Externí odkaz:
https://doaj.org/article/5e71f08ee1a54b03b4facdc1e3b04458
Autor:
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Göknur Giner, Stephanie Trezise, Ashley P. Ng, Gerry Healey, Serena R. Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J. Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S. Alexander, Jane E. Visvader, Stephen L. Nutt, Andreas Strasser, Benjamin Haley, Quan Zhao, Gemma L. Kelly, Marco J. Herold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Modelling of aggressive lymphomas, such as double hit lymphoma, has been challenging. Here the authors engineer a CRISPR activation mouse to enable the generation of these aggressive lymphomas and identify the pro-survival BCL-2 protein A1 as a venet
Externí odkaz:
https://doaj.org/article/a6a1367d102e4deb8dbd0ddb559ac31c
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-6 (2022)
Programmed cell death, in particular the intrinsic apoptotic pathway, has been shown to play a critical role in the shaping of tissues during embryonic development. The multi-BCL-2 Homology (BH) domain effectors of apoptosis, BAX, BAK, and BOK, are e
Externí odkaz:
https://doaj.org/article/fac68ffed72f4a9c8e2a9daa6dcfa08a
Autor:
Luuk Heitink, James R. Whittle, François Vaillant, Bianca D. Capaldo, Johanna F. Dekkers, Caleb A. Dawson, Michael J. G. Milevskiy, Elliot Surgenor, Minhsuang Tsai, Huei‐Rong Chen, Michael Christie, Yunshun Chen, Gordon K. Smyth, Marco J. Herold, Andreas Strasser, Geoffrey J. Lindeman, Jane E. Visvader
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1119-1131 (2022)
Breast cancer is a heterogeneous disease that comprises multiple histological and molecular subtypes. To gain insight into mutations that drive breast tumorigenesis, we describe a pipeline for the identification and validation of tumor suppressor gen
Externí odkaz:
https://doaj.org/article/a2c6e54222254a7aaa2607785b7929bf
Autor:
Lahiru Gangoda, Robyn L. Schenk, Lin Tai, Pacman Szeto, Jen G. Cheung, Andreas Strasser, Guillaume Lessene, Mark Shackleton, Marco J. Herold
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/fa7b8c7907f34a2890e07c751553ec89
Autor:
Jun T. Low, Gwo-Yaw Ho, Mark Scott, Chin Wee Tan, Lachlan Whitehead, Kathy Barber, Hon Y. K. Yip, Johanna F. Dekkers, Yumiko Hirokawa, John Silke, Antony W. Burgess, Andreas Strasser, Tracy L. Putoczki, Lorraine A. O’Reilly
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/29594c5b650d41c2b05a76d8d62358cb
Autor:
Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S. P. Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T. Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan, Philipp J. Jost
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Cancer cells frequently harbour genetic aberrations that protect them from programmed cell death. Here, the authors show in non-small cell lung cancer that the anti-apoptotic gene MCL-1 is subject to copy number gains and that deletion of MCL-1 reduc
Externí odkaz:
https://doaj.org/article/e72e961b8ad54302879663e878f7c62b
Autor:
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Göknur Giner, Stephanie Trezise, Ashley P. Ng, Gerry Healey, Serena R. Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J. Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S. Alexander, Jane E. Visvader, Stephen L. Nutt, Andreas Strasser, Benjamin Haley, Quan Zhao, Gemma L. Kelly, Marco J. Herold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/cc4c296b2b374573b5cc8009f758bbc9
Autor:
Sarah T. Diepstraten, Savannah Young, John E. La Marca, Zilu Wang, Ruth M. Kluck, Andreas Strasser, Gemma L. Kelly
Publikováno v:
Cell Death & Differentiation. 30:1005-1017
BH3-mimetic drugs are an anti-cancer therapy that can induce apoptosis in malignant cells by directly binding and inhibiting pro-survival proteins of the BCL-2 family. The BH3-mimetic drug venetoclax, which targets BCL-2, has been approved for the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85ea1312259fcc81d8a6fbbe2c9ad788
https://doi.org/10.1038/s41418-023-01117-0
https://doi.org/10.1038/s41418-023-01117-0