Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Andreas, Schepky"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 12, Pp 2052-2067 (2024)
Abstract Sensitivity analyses are important components of physiologically based pharmacokinetic (PBPK) model development and are required by regulatory agencies for PBPK submissions. They assess the impact of parametric uncertainty and variability on
Externí odkaz:
https://doaj.org/article/6f1bf57938af423bb7b8b82f85c954f8
Autor:
Abdulkarim Najjar, Jochen Kühnl, Daniela Lange, Camille Géniès, Carine Jacques, Eric Fabian, Anne Zifle, Nicola J. Hewitt, Andreas Schepky
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: We performed an exposure-based Next Generation Risk Assessment case read-across study using New Approach Methodologies (NAMs) to determine the highest safe concentration of daidzein in a body lotion, based on its similarities with its s
Externí odkaz:
https://doaj.org/article/da1994c1f9ce46a6a0656cab9deda374
Autor:
Tomaz Mohoric, Anke Wilm, Stefan Onken, Andrii Milovich, Artem Logavoch, Pascal Ankli, Ghada Tagorti, Johannes Kirchmair, Andreas Schepky, Jochen Kühnl, Abdulkarim Najjar, Barry Hardy, Johanna Ebmeyer
Publikováno v:
Toxics, Vol 12, Iss 9, p 666 (2024)
Skin sensitisation is a critical adverse effect assessed to ensure the safety of compounds and materials exposed to the skin. Alongside the development of new approach methodologies (NAMs), defined approaches (DAs) have been established to promote sk
Externí odkaz:
https://doaj.org/article/40414bbdcbce42a481b35ab28df41d2f
Autor:
Johanna Ebmeyer, Abdulkarim Najjar, Daniela Lange, Mareike Boettcher, Silja Voß, Katrin Brandmair, Jaqueline Meinhardt, Jochen Kuehnl, Nicola J. Hewitt, Christopher-Tilman Krueger, Andreas Schepky
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
We performed an ab initio next-generation risk assessment (NGRA) for a fragrance ingredient, benzyl salicylate (BSal), to demonstrate how cosmetic ingredients can be evaluated for systemic toxicity endpoints based on non-animal approaches. New approa
Externí odkaz:
https://doaj.org/article/1275c47fc0a743e199b7ff8ff499d8a3
Autor:
Cassandra Falckenhayn, Agata Bienkowska, Jörn Söhle, Katrin Wegner, Guenter Raddatz, Boris Kristof, Dirk Kuck, Ralf Siegner, Ronny Kaufmann, Julia Korn, Sascha Baumann, Daniela Lange, Andreas Schepky, Henry Völzke, Lars Kaderali, Marc Winnefeld, Frank Lyko, Elke Grönniger
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with deregulated gene expression and impaired tissue functionality, leading to the well-known skin a
Externí odkaz:
https://doaj.org/article/41b18a4c3c734ca79c31cb048d5cc259
Autor:
Thi-Phuong Tao, Ilka Maschmeyer, Edward L. LeCluyse, Eda Rogers, Katrin Brandmair, Silke Gerlach, Julia Przibilla, Fredy Kern, Camille Genies, Carine Jacques, Abdulkarim Najjar, Andreas Schepky, Uwe Marx, Jochen Kühnl, Nicola J. Hewitt
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more complex higher tier model to evaluate chemicals. Having established a skin and liver HUMIMIC Chip
Externí odkaz:
https://doaj.org/article/5068186205ee485da21ca6a4409cc5d3
Autor:
Abdulkarim Najjar, Andreas Schepky, Christopher-Tilman Krueger, Matthew Dent, Sophie Cable, Hequn Li, Sebastien Grégoire, Laurene Roussel, Audrey Noel-Voisin, Nicola J. Hewitt, Estefania Cardamone
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Ethical and legal considerations have led to increased use of non-animal methods to evaluate the safety of chemicals for human use. We describe the development and qualification of a physiologically-based kinetics (PBK) model for the cosmetic UV filt
Externí odkaz:
https://doaj.org/article/9acf312947514a1ab3886fc1447ba059
Autor:
Ilka Maschmeyer, Julia Przibilla, Thi Phuong Tao, Camille Genies, Carine Jacques-Jamin, Andreas Schepky, Uwe Marx, Katrin Brandmair, Nicola J. Hewitt, Jochen Kühnl, Silke Gerlach
Publikováno v:
Journal of Applied Toxicology. 41:1553-1567
We used TissUse's HUMIMIC Chip2 microfluidic model, incorporating reconstructed skin models and liver spheroids, to investigate the impact of consumer-relevant application scenarios on the metabolic fate of the hair dye, 4-amino-2-hydroxytoluene (AHT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20001faf92cda0c6cc4e81a1c2453cca
https://doi.org/10.1002/jat.4146
https://doi.org/10.1002/jat.4146
Autor:
Andreas, Natsch, Caroline, Bauch, Leslie, Foertsch, Frank, Gerberick, Kimberly, Norman, Allison, Hilberer, Heather, Inglis, Robert, Landsiedel, Stefan, Onken, Hendrik, Reuter, Andreas, Schepky, Roger, Emter
Publikováno v:
In Toxicology in Vitro April 2011 25(3):733-744
Autor:
Eric Arbey, Richard Cubberley, Joan Eilstein, Martina Klaric, Hélène Duplan, Carine Jacques-Jamin, Nicola J. Hewitt, Corie A. Ellison, Camille Genies, Helga Rothe, Daniela Lange, Aurélie Fabre, Sébastien Grégoire, Andreas Schepky
Publikováno v:
Journal of Applied Toxicology. 40:416-433
The abundance of xenobiotic metabolizing enzymes (XMEs) is different in the skin and liver; therefore, it is important to differentiate between liver and skin metabolism when applying the information to safety assessment of topically applied ingredie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a426ce4e883d06c3f8e4603b7b0c4be3
https://doi.org/10.1002/jat.3914
https://doi.org/10.1002/jat.3914