Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Andreas, Plaitakis"'
Autor:
Cleanthe Spanaki, Kyriaki Sidiropoulou, Zoe Petraki, Konstantinos Diskos, Xanthippi Konstantoudaki, Emmanouela Volitaki, Konstantina Mylonaki, Maria Savvaki, Andreas Plaitakis
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108821- (2024)
Summary: The human brain is characterized by the upregulation of synaptic, mainly glutamatergic, transmission, but its evolutionary origin(s) remain elusive. Here we approached this fundamental question by studying mice transgenic (Tg) for GLUD2, a h
Externí odkaz:
https://doaj.org/article/615683b44ddf4d8b852c3b8e18b8e65f
Autor:
Ionela Litso, Andreas Plaitakis, Vasiliki E. Fadouloglou, Mary Providaki, Michael Kokkinidis, Ioannis Zaganas
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 22 (2023)
Glutamate dehydrogenase (GDH) interconverts glutamate to a-ketoglutarate and ammonia, interconnecting amino acid and carbohydrate metabolism. In humans, two functional GDH genes, GLUD1 and GLUD2, encode for hGDH1 and hGDH2, respectively. GLUD2 evolve
Externí odkaz:
https://doaj.org/article/527a46d2d2794c3a9a0c02dd7f94986e
Autor:
Lambros Mathioudakis, Christina Dimovasili, Mara Bourbouli, Helen Latsoudis, Evgenia Kokosali, Garyfallia Gouna, Emmanouella Vogiatzi, Maria Basta, Stefania Kapetanaki, Simeon Panagiotakis, Alexandros Kanterakis, Dimitrios Boumpas, Christos Lionis, Andreas Plaitakis, Panagiotis Simos, Alexandros Vgontzas, Dimitrios Kafetzopoulos, Ioannis Zaganas
Publikováno v:
Neurobiology of Aging. 123:111-128
Using exome sequencing, we analyzed 196 participants of the Cretan Aging Cohort (CAC; 95 with Alzheimer's disease [AD], 20 with mild cognitive impairment [MCI], and 81 cognitively normal controls). The APOE ε4 allele was more common in AD patients (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e5f6eb53065833a6fd3d09f300d861
https://doi.org/10.1016/j.neurobiolaging.2022.07.002
https://doi.org/10.1016/j.neurobiolaging.2022.07.002
Autor:
Minas Tzagournissakis, Emmanouil Foukarakis, Dimitrios Samonakis, Miltiadis Tsilimbaris, Kleita Michaelidou, Lambros Mathioudakis, Anastasios Marinis, Emmanouil Giannakoudakis, Cleanthe Spanaki, Irene Skoula, Sofia Erimaki, Georgios Amoiridis, Georgios Koutsis, Sofia Koukouraki, Kostas Stylianou, Andreas Plaitakis, Panayiotis D. Mitsias, Ioannis Zaganas
Publikováno v:
Neurology. Genetics. 8(5)
Background and ObjectivesOur goal was to study hereditary transthyretin-related amyloidosis (hATTR) in Crete, Greece.MethodsWe aimed at ascertaining all hATTR cases in Crete, an island of 0.62 million people. For this, we evaluated patients with poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9212bb23c9feac829a225e63c1c149
https://pubmed.ncbi.nlm.nih.gov/36101541
https://pubmed.ncbi.nlm.nih.gov/36101541
Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome
Autor:
Theodora Panou, Vasileios Mastorodemos, Efrosyni Papadaki, Panagiotis G. Simos, Andreas Plaitakis
Publikováno v:
Behavioural Neurology, Vol 25, Iss 4, Pp 311-326 (2012)
The study investigates primary and secondary verbal memory and motor/executive functions (response inhibition and strategy shifting ability) in multiple sclerosis (MS) patients with clinically isolated syndrome (CIS). We studied 44 CIS patients and c
Externí odkaz:
https://doaj.org/article/ddabad739dcd4d9aad859d7cd5350b54
Publikováno v:
Biology, Vol 6, Iss 1, p 11 (2017)
Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD(P)+ to NAD(P)H. It is found in all living organisms serving both catabolic and anabolic react
Externí odkaz:
https://doaj.org/article/701a0dc953c948709fc5e5c7351d7df6
Autor:
Efrosini Z. Papadaki, Panagiotis G. Simos, Vasileios C. Mastorodemos, Theodora Panou, Thomas G. Maris, Apostolos H. Karantanas, Andreas Plaitakis
Publikováno v:
Behavioural Neurology, Vol 2014 (2014)
Background. Patients with clinically isolated syndrome (CIS) demonstrate brain hemodynamic changes and also suffer from difficulties in processing speed, memory, and executive functions. Objective. To explore whether brain hemodynamic disturbances in
Externí odkaz:
https://doaj.org/article/53d439bb40934f2f84eb356eb097a07d
Autor:
Aikaterini Kefala, Mary Providaki, Andreas Plaitakis, Konstantinos Kanavouras, Vasiliki E. Fadouloglou, Michael Kokkinidis, Dina Kotsifaki, Christina Dimovasili, Ioannis Zaganas, Iosifina Sarrou
Publikováno v:
Journal of neurochemistry 157(3), 802-815 (2021). doi:10.1111/jnc.15296
Journal of neurochemistry 157(3), 802 - 815 (2021). doi:10.1111/jnc.15296
Mammalian glutamate dehydrogenase (hGDH1 in human cells) interconverts glutamate to ��-ketoglutarate and ammonia while reducing NAD(P) to NAD(P)H. During primate evolu
Mammalian glutamate dehydrogenase (hGDH1 in human cells) interconverts glutamate to ��-ketoglutarate and ammonia while reducing NAD(P) to NAD(P)H. During primate evolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c75db608c62ebff2d9310b07cf7c55
Autor:
Maria Delidaki, Dimitra Kotzamani, Ioannis Zaganas, Zoe Petraki, Kyriaki Sidiropoulou, Eleni Douni, Andreas Plaitakis, Vagelis Rinotas, Cleanthe Spanaki
Publikováno v:
Neurochemical Research. 44:154-169
Human evolution is characterized by brain expansion and up-regulation of genes involved in energy metabolism and synaptic transmission, including the glutamate signaling pathway. Glutamate is the excitatory transmitter of neural circuits sub-serving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861f7de6c7885b5d39e4be0d44e2f8e8
https://doi.org/10.1007/s11064-018-2546-3
https://doi.org/10.1007/s11064-018-2546-3
Autor:
Zoe Petraki, Stavros Droubogiannis, Cleanthe Spanaki, Konstantina Mylonaki, Gregory Chlouverakis, Andreas Plaitakis
Publikováno v:
Metabolism: clinical and experimental. 100
Glutamate dehydrogenase 1 (GDH1) contributes to glucose-stimulated insulin secretion in murine β-cells, but not to basic insulin release. The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489b149344af37090d2b9dc5eaa30a0a
https://pubmed.ncbi.nlm.nih.gov/31400387
https://pubmed.ncbi.nlm.nih.gov/31400387