Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andreas, Marg"'
Autor:
Stefanie Müthel, Andreas Marg, Busem Ignak, Janine Kieshauer, Helena Escobar, Christian Stadelmann, Simone Spuler
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 494-511 (2023)
With thousands of patients worldwide, CAPN3 c.550delA is the most frequent mutation causing severe, progressive, and untreatable limb girdle muscular dystrophy. We aimed to genetically correct this founder mutation in primary human muscle stem cells.
Externí odkaz:
https://doaj.org/article/8e7f62ae77464719b1429f20e61ee163
Autor:
Biniam M. Bekele, Verena Schöwel‐Wolf, Janine Kieshauer, Andreas Marg, Andreas Busjahn, Sarah Davis, Gayle Nugent, Anne‐Karoline Ebert, Simone Spuler
Publikováno v:
Animal Models and Experimental Medicine, Vol 5, Iss 5, Pp 453-460 (2022)
Abstract Background The aim of the study was to demonstrate the efficacy of human muscle stem cells (MuSCs) isolated using innovative technology in restoring internal urinary sphincter function in a preclinical animal model. Methods Colonies of pure
Externí odkaz:
https://doaj.org/article/35445e124c5546d793caec04591c937f
Autor:
Christian Stadelmann, Silvia Di Francescantonio, Andreas Marg, Stefanie Müthel, Simone Spuler, Helena Escobar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 47-57 (2022)
Muscular dystrophies are approximately 50 devastating, untreatable monogenic diseases leading to progressive muscle degeneration and atrophy. Gene correction of transplantable cells using CRISPR/Cas9-based tools is a realistic scenario for autologous
Externí odkaz:
https://doaj.org/article/bca5f4941def4db8a722074c437a2bbb
Autor:
Andreas Marg, Helena Escobar, Nikos Karaiskos, Stefanie A. Grunwald, Eric Metzler, Janine Kieshauer, Sascha Sauer, Diana Pasemann, Edoardo Malfatti, Dominique Mompoint, Susanna Quijano-Roy, Anastasiya Boltengagen, Joanna Schneider, Markus Schülke, Séverine Kunz, Robert Carlier, Carmen Birchmeier, Helge Amthor, Andreas Spuler, Christine Kocks, Nikolaus Rajewsky, Simone Spuler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Skeletal muscle stem cells express the transcription factor Pax7. Here, the authors isolate, from human muscle, cells that are positive for the endothelial marker CLEC14A and show that despite not expressing pax7, these cells regenerate muscle and co
Externí odkaz:
https://doaj.org/article/ce96cb57dae14384b0b97d2a3e6fda84
Autor:
Jakub Malcher, Leonie Heidt, Aurélie Goyenvalle, Helena Escobar, Andreas Marg, Cyriaque Beley, Rachid Benchaouir, Michael Bader, Simone Spuler, Luis García, Verena Schöwel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 198-207 (2018)
Limb girdle muscular dystrophy 2B (LGMD2B) is without treatment and caused by mutations in the dysferlin gene (DYSF). One-third is missense mutations leading to dysferlin aggregation and amyloid formation, in addition to defects in sarcolemmal repair
Externí odkaz:
https://doaj.org/article/5d1d3497ef3d4ad2a0b0bfd742e30f43
Autor:
Joanna Schneider, Devakumar Sundaravinayagam, Alexander Blume, Andreas Marg, Stefanie Grunwald, Eric Metzler, Helena Escobar, Stefanie Müthel, Haicui Wang, Tobias Wollersheim, Steffen Weber-Carstens, Altuna Akalin, Michela Di Virgilio, Baris Tursun, Simone Spuler
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2772
Volume 24
Issue 3
Pages: 2772
Critical illness myopathy (CIM) is an acquired, devastating, multifactorial muscle-wasting disease with incomplete recovery. The impact on hospital costs and permanent loss of quality of life is enormous. Incomplete recovery might imply that the func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2721f8febd346746cededad8cc3848
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Dysferlin-deficient muscular dystrophy is a progressive disease characterized by muscle weakness and wasting for which there is no treatment. It is caused by mutations in DYSF, a large, multiexonic gene that forms a coding sequence of 6.2 kb. Sleepin
Externí odkaz:
https://doaj.org/article/1281b7ce905d4d4ba2d014d81e7e9328
Autor:
Christian Stadelmann, Silvia Di Francescantonio, Andreas Marg, Stefanie Müthel, Simone Spuler, Helena Escobar
Publikováno v:
Molecular therapy. Nucleic acids. 28
Muscular dystrophies are about 50 devastating untreatable monogenic diseases leading to progressive muscle degeneration and atrophy. Gene correction of transplantable cells using CRISPR/Cas9-based tools is a realistic scenario for autologous cell rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc1ea145d53d97bfdbdbf46e9312c9b
https://pubmed.ncbi.nlm.nih.gov/35356683
https://pubmed.ncbi.nlm.nih.gov/35356683
Autor:
Verena Schoewel, Andreas Marg, Severine Kunz, Tim Overkamp, Romy Siegert Carrazedo, Ute Zacharias, Peter T Daniel, Simone Spuler
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49603 (2012)
Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dystrophy, LGMD2B. There is no therapy. Dysferlin is a membrane protein comprised of seven, beta-sheet enriched, C2 domains and is involved in Ca(2+)dependent sa
Externí odkaz:
https://doaj.org/article/cb39ce123be842d29078789a4fcd6651
The biological effects of cytokines are mediated by STAT proteins, a family of dimeric transcription factors. In order to elicit transcriptional activity, the STATs require activation by phosphorylation of a single tyrosine residue. Our experiments r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31f4056a2e33ff869919d5dca9f46e8
https://europepmc.org/articles/PMC5473235/
https://europepmc.org/articles/PMC5473235/
