Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Andreas, Kupz"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Innate immune cells, such as macrophages, mount an immune response upon exposure to antigens and pathogens. Emerging evidence shows that macrophages exposed to an antigen can generate a “memory-like” response (a.k.a. trained immunity), w
Externí odkaz:
https://doaj.org/article/0f87e52fdedf4779bd3c811a4c598d7e
Autor:
Tammy Allen, Maria Eugenia Castellanos, Paul Giacomin, Nadira D. Karunaweera, Andreas Kupz, Juan Carlos Lol, Dileep Sharma, Suchandan Sikder, Bemnet Tedla, Liza van Eijk, Danica Vojisavljevic, Guangzu Zhao, Saparna Pai
Publikováno v:
International Journal of Infectious Diseases, Vol 143, Iss , Pp 107014- (2024)
Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. Although anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer a promisin
Externí odkaz:
https://doaj.org/article/e967e76a9cd94a109368f6690799a557
Autor:
Nancy Wang, Timothy A Scott, Andreas Kupz, Meghanashree M Shreenivas, Newton G Peres, Dianna M Hocking, Chenying Yang, Leila Jebeli, Lynette Beattie, Joanna R Groom, Thomas P Pierce, Linda M Wakim, Sammy Bedoui, Richard A Strugnell
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011666 (2023)
Prior infection can generate protective immunity against subsequent infection, although the efficacy of such immunity can vary considerably. Live-attenuated vaccines (LAVs) are one of the most effective methods for mimicking this natural process, and
Externí odkaz:
https://doaj.org/article/f3d56009cb644d75a2d9d9ab1727aad4
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Tuberculosis (TB) has remained at the forefront of the global infectious disease burden for centuries. Concerted global efforts to eliminate TB have been hindered by the complexity of Mycobacterium tuberculosis (Mtb), the emergence of antibiotic resi
Externí odkaz:
https://doaj.org/article/dbe8034e30df48e9a18a5e0f5964a454
Autor:
Amali Karunathilaka, Samuel Halstrom, Patricia Price, Michael Holt, Viviana P. Lutzky, Denise L. Doolan, Andreas Kupz, Scott C. Bell, Rachel M. Thomson, John J. Miles, Champa N. Ratnatunga
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-8 (2022)
Abstract γδ T cells are a highly versatile immune lineage involved in host defense and homeostasis, but questions remain around their heterogeneity, precise function and role during health and disease. We used multi−parametric flow cytometry, dim
Externí odkaz:
https://doaj.org/article/fb172ebadebe414fa4a5dedc70fc85ea
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tuberculosis (TB) remains one of the most lethal infectious diseases globally. The only TB vaccine approved by the World Health Organization, Bacille Calmette-Guérin (BCG), protects children against severe and disseminated TB but provides limited pr
Externí odkaz:
https://doaj.org/article/33ef7735b5954afeb9d9a089172826f8
Autor:
Champa N. Ratnatunga, Katie Tungatt, Carla Proietti, Sam Halstrom, Michael R. Holt, Viviana P. Lutzky, Patricia Price, Denise L. Doolan, Scott C. Bell, Matt A. Field, Andreas Kupz, Rachel M. Thomson, John J. Miles
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic, progressive, and growing worldwide health burden associated with mounting morbidity, mortality, and economic costs. Improvements in NTM-PD management are urgently needed, which re
Externí odkaz:
https://doaj.org/article/fba668e651114e49b81917d41e8bd331
Autor:
Harindra D. Sathkumara, Janet L. Eaton, Matt A. Field, Brenda L. Govan, Natkunam Ketheesan, Andreas Kupz
Publikováno v:
Animal Models and Experimental Medicine, Vol 4, Iss 2, Pp 181-188 (2021)
Abstract Tuberculosis (TB) is one of the deadliest infectious diseases in the world. The metabolic disease type 2 diabetes (T2D) significantly increases the risk of developing active TB. Effective new TB vaccine candidates and novel therapeutic inter
Externí odkaz:
https://doaj.org/article/86bbf6f428ef4e3287774325d51cef76
Autor:
Newton G. Peres, Nancy Wang, Paul Whitney, Sven Engel, Meghanashree M. Shreenivas, Ian Comerford, Dianna M. Hocking, Anna B. Erazo, Irmgard Förster, Andreas Kupz, Thomas Gebhardt, Shaun R. McColl, Stephen J. McSorley, Sammy Bedoui, Richard A. Strugnell
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen
Externí odkaz:
https://doaj.org/article/2cba44dd59ea4403844f41d34e30910e
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2749 (2022)
Vaccination is an excellent approach to stimulating the host immune response and reducing human morbidity and mortality against microbial infections, such as tuberculosis (TB). Bacillus Calmette–Guerin (BCG) is the most widely administered vaccine
Externí odkaz:
https://doaj.org/article/fec9cbc3aa1d400fb754930594ab9bc3