Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Andreas, Jekle"'
Autor:
Cheng Liu, Sarah Stevens, Heleen Roose, Kha Le, Kristina Rekstyte-Matiene, Kusum Gupta, Sandra Chang, Vladimir Serebryany, Lillian Adame, Antitsa Stoycheva, Lawrence M Blatt, Leonid Beigelman, Sushmita Chanda, David B Smith, Julian A Symons, Andreas Jekle, Tongfei Wu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/c170486abb824f06906cb4f47c056214
Autor:
Cheng Liu, Sarah Stevens, Heleen Roose, Kha Le, Kristina Rekstyte-Matiene, Kusum Gupta, Sandra Chang, Vladimir Serebryany, Lillian Adame, Antitsa Stoycheva, Lawrence M Blatt, Leonid Beigelman, Sushmita Chanda, David B Smith, Julian A Symons, Andreas Jekle, Tongfei Wu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/875cd85b72334cbe84a2cbfc4b70946f
Autor:
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K. Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M. Blatt, Leonid Beigelman, Julian A. Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors to select for drug-resistant variants needs to be establish
Externí odkaz:
https://doaj.org/article/68b3f8dcc3b24cffa15d8cab99c36119
Autor:
Xuan G Luong, Sarah K Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Dinah Misner, Sushmita Chanda, Sucheta Mukherjee, Caroline Williams, Antitsa Stoycheva, Lawrence M Blatt, Leonid N Beigelman, Julian A Symons, Pierre Raboisson, David McGowan, Koen Vandyck, Jerome Deval
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0240338 (2020)
Thyroid hormones are important modulators of metabolic activity in mammals and alter cholesterol and fatty acid levels through activation of the nuclear thyroid hormone receptor (THR). Currently, there are several THRβ agonists in clinical trials fo
Externí odkaz:
https://doaj.org/article/9888716071a5408e90bb5d9370ea3a38
Autor:
Dieudonné Buh Kum, Hannah Vanrusselt, Abel Acosta Sanchez, Valerio Taverniti, Eloi R. Verrier, Thomas F. Baumert, Cheng Liu, Jerome Deval, Nikky Corthout, Sebastian Munck, Leonid Beigelman, Lawrence M. Blatt, Julian A. Symons, Pierre Raboisson, Andreas Jekle, Sandrine Vendeville, Yannick Debing
Publikováno v:
Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4755e456e6fad652ab68e05b5b5a46b
https://doi.org/10.1097/hep.0000000000000428
https://doi.org/10.1097/hep.0000000000000428
Autor:
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M Blatt, Leonid Beigelman, Julian A Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors to select for drug-resistant variants needs to be established. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c36125eb5d31998d4c26e9978f474d0c
https://doi.org/10.1101/2022.06.07.495116
https://doi.org/10.1101/2022.06.07.495116
Autor:
Antitsa Dimitrova Stoycheva, Leonid Beigelman, Tongqian Chen, Kenneth Shaw, Vivek K. Rajwanshi, Zhinan Jin, Andreas Jekle, Yujian Hu, Kusum Gupta, Caroline Williams, Amy Fung, Guangyi Wang, Vladimir Serebryany, Natalia B. Dyatkina, Xiangyang Wu, Marija Prhavc, Jerome Deval, David B. Smith, Wensheng Huang, Yuen Tam, Yongfei Huang
Publikováno v:
Journal of Medicinal Chemistry. 63:10380-10395
Chronic hepatitis C (CHC) is a major liver disease caused by the hepatitis C virus. The current standard of care for CHC can achieve cure rates above 95%; however, the drugs in current use are administered for a period of 8-16 weeks. A combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a823c2f5eb258939c818fe7c940eb7e5
https://doi.org/10.1021/acs.jmedchem.0c00935
https://doi.org/10.1021/acs.jmedchem.0c00935
Publikováno v:
Neglected Tropical Diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bbb9fccbb5b9652b40f6c0e41118e29
https://doi.org/10.1002/9783527808656.ch2
https://doi.org/10.1002/9783527808656.ch2
Autor:
Leonid Beigelman, Jerome Deval, Lawrence M. Blatt, Dorothée Bardiot, Laura Vangeel, Sandro Boland, Johan Neyts, Cheng Liu, Steven Dejonghe, Dinah Misner, Andreas Jekle, Pierre Raboisson, Sushmita Mukherjee Chanda, Vladimir Serebryany, Caroline S. Foo, Koen Vandyck, Arnaud Marchand, Suping Ren, Julian A. Symons, Patrick Chaltin, Kusum Gupta, Antitsa Dimitrova Stoycheva, Dirk Jochmans, Rana Abdelnabi
Publikováno v:
Biochemical and Biophysical Research Communications
There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents a promising target for antiviral therapy. The lack of selectivity for some of the reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f364b0af0bca75044f48bf96844cbe8
https://lirias.kuleuven.be/handle/123456789/673810
https://lirias.kuleuven.be/handle/123456789/673810
Autor:
Andreas Jekle, Julian A. Symons, Sushmita Mukherjee Chanda, Vladimir Serebryany, Leonid Beigelman, Cheng Liu, Rana Abdelnabi, Suping Ren, Steven Dejonghe, Sandro Boland, Johan Neyts, Dorothée Bardiot, Dinah Misner, Antitsa Dimitrova Stoycheva, Patrick Chaltin, Jerome Deval, Pierre Raboisson, Kusum Gupta, Koen Vandyck, Dirk Jochmans, Caroline S. Foo, Arnaud Marchand, Lawrence M. Blatt, Laura Vangeel
There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents a promising target for antiviral therapy. The lack of selectivity for some of the reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7502a8f400fdb028d390f18fc0e96d
https://doi.org/10.1101/2021.02.14.431129
https://doi.org/10.1101/2021.02.14.431129