Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Andreas, Heine"'
Autor:
Anke-Dorothee Werner, Nils Krapoth, Michael J. Norris, Andreas Heine, Gerhard Klebe, Erica Ollmann Saphire, Stephan Becker
Publikováno v:
ACS Omega, Vol 9, Iss 30, Pp 33193-33203 (2024)
Externí odkaz:
https://doaj.org/article/35426d60ad6248b28f7e4aa3aa389ab4
Autor:
Francesca Magari, Henri Messner, Florian Salisch, Stella M. Schmelzle, Ger van Zandbergen, Alois Fürstner, John Ziebuhr, Andreas Heine, Christin Müller-Ruttloff, Arnold Grünweller
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33409- (2024)
Pateamines, derived from the sponge Mycale hentscheli, function as inhibitors of the RNA helicase eIF4A and exhibit promising antiviral and anticancer properties. eIF4A plays a pivotal role in unwinding stable RNA structures within the 5′-UTR of se
Externí odkaz:
https://doaj.org/article/e13316ce04ee406aae29ecf9b4ec549a
Autor:
Stefano Signetti, Andreas Heine
Publikováno v:
Defence Technology, Vol 31, Iss , Pp 49-57 (2024)
Towards higher impact velocities, ballistic events are increasingly determined by the material temperatures. Related effects might range from moderate thermal softening to full phase transition. In particular, it is of great interest to quantify the
Externí odkaz:
https://doaj.org/article/f61e6d5c6ee24c0e8e8b16544a031e02
Autor:
Andreas Heine, Matthias Wickert
Publikováno v:
Defence Technology, Vol 31, Iss , Pp 607-609 (2024)
A recently published modeling approach for the penetration into adobe and previous approaches implicitly criticized are reviewed and discussed.This article contains a note on the paper titled “Ballistic model for the prediction of penetration depth
Externí odkaz:
https://doaj.org/article/8d71e13e9db748beaf7a7bf931949046
Autor:
Marina Gárdonyi, Christian Hasewinkel, Johanna Wallbaum, Jan Wollenhaupt, Manfred S. Weiss, Gerhard Klebe, Klaus Reuter, Andreas Heine
Publikováno v:
ACS Omega, Vol 8, Iss 48, Pp 46051-46065 (2023)
Externí odkaz:
https://doaj.org/article/5bde61bba2284f389909af2957a03088
Autor:
Franziska U. Huschmann, Janis Mueller, Alexander Metz, Moritz Ruf, Johanna Senst, Serghei Glinca, Johannes Schiebel, Andreas Heine, Gerhard Klebe
Publikováno v:
Crystals, Vol 14, Iss 9, p 755 (2024)
Fragment screening directly on protein crystals has been applied using AnalytiCon’s collection of intermediates that have been utilized to generate libraries of larger synthetic natural product-like molecules. The fragments with well-balanced physi
Externí odkaz:
https://doaj.org/article/4e95b53a82e24820bf05c4f364b32dbd
Autor:
Wiebke Obermann, Mohammad Farhan Darin Azri, Leonie Konopka, Nina Schmidt, Francesca Magari, Julian Sherman, Liliana M. R. Silva, Carlos Hermosilla, Andreas H. Ludewig, Hicham Houhou, Simone Haeberlein, Mona Yiting Luo, Irina Häcker, Marc F. Schetelig, Christoph G. Grevelding, Frank C. Schroeder, Gilbert Sei Kung Lau, Anja Taubert, Ana Rodriguez, Andreas Heine, Tiong Chia Yeo, Arnold Grünweller, Gaspar Taroncher-Oldenburg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A inhibitors, but their anti-pathogenic potential has not been comprehensively assessed
Externí odkaz:
https://doaj.org/article/8922ae7cbaff49e69d1bb970b63c9468
Autor:
Johannes Schiebel, Roberto Gaspari, Tobias Wulsdorf, Khang Ngo, Christian Sohn, Tobias E. Schrader, Andrea Cavalli, Andreas Ostermann, Andreas Heine, Gerhard Klebe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Trypsin is a serine protease. Here the authors present the high resolution X-ray and neutron diffraction structures of uncomplexed and inhibitor bound trypsin that provide insights into the geometry of H-bonds in the active site of the enzyme and mol
Externí odkaz:
https://doaj.org/article/dfa101099f7848ffada5601ea4aa65b1
Autor:
Anna Sandner, Khang Ngo, Christoph P. Sager, Frithjof Scheer, Michael Daude, Wibke E. Diederich, Andreas Heine, Gerhard Klebe
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1837 (2021)
The transient specificity pocket of aldose reductase only opens in response to specific ligands. This pocket may offer an advantage for the development of novel, more selective ligands for proteins with similar topology that lack such an adaptive poc
Externí odkaz:
https://doaj.org/article/d281860ce9d74c0db718c7b1b1b9ce96
Autor:
Maurice Sebastiani, Christina Behrens, Stefanie Dörr, Hans-Dieter Gerber, Rania Benazza, Oscar Hernandez-Alba, Sarah Cianférani, Gerhard Klebe, Andreas Heine, Klaus Reuter
Publikováno v:
ACS Chemical Biology. 17:2229-2247
In tRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f71ab9cd3de511f3f5feba57768aaeb
https://doi.org/10.1021/acschembio.2c00368
https://doi.org/10.1021/acschembio.2c00368