Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andreas, Feichtner"'
Autor:
Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan
Publikováno v:
eLife, Vol 13 (2024)
Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of suc
Externí odkaz:
https://doaj.org/article/71c92e4b1a0b490fa5cb3387e2ae8a9c
Autor:
Alexander Mödlhammer, Sandra Pfurtscheller, Andreas Feichtner, Markus Hartl, Rainer Schneider
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The c-Myc protein (MYC) is a transcription factor with strong oncogenic potential controlling fundamental cellular processes. In most human tumors, MYC is overexpressed by enhanced transcriptional activation, gene amplification, chromosomal rearrange
Externí odkaz:
https://doaj.org/article/39dabf86ccb3473f82ec8aac7c939559
Autor:
Jakob Fleischmann, Andreas Feichtner, Louis DeFalco, Valentina Kugler, Selina Schwaighofer, Roland G Huber, Eduard Stefan
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 518 (2021)
Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling pathway lead to aberrant activation of the involved protein kinase entities. These oncogenic modifications alter signal propagation which converge on the gatekeepe
Externí odkaz:
https://doaj.org/article/6411160c8b174af68957ffdf8eb8a5b7
Autor:
Andreas Feichtner, Valentina Kugler, Selina Schwaighofer, Thomas Nuener, Jakob Fleischmann, Eduard Stefan
Publikováno v:
memo - Magazine of European Medical Oncology. 15:137-142
SummaryNumerous kinases act as central nodes of cellular signaling networks. As such, many of these enzymes function as molecular switches for coordinating spatiotemporal signal transmission. Typically, it is the compartmentalized phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c42e2c378d6dd26571d476f3e9b412
https://doi.org/10.1007/s12254-021-00790-6
https://doi.org/10.1007/s12254-021-00790-6
Autor:
Christina S Moesslacher, Jonathan Woodsmith, Elisabeth Auernig, Andreas Feichtner, Evelyne Jany-Luig, Stefanie Jehle, Josephine M Worseck, Christian L Heine, Eduard Stefan, Ulrich Stelzl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266d3e782731c48dab3fa116afc35454
https://doi.org/10.15252/rc.2023269367
https://doi.org/10.15252/rc.2023269367
Autor:
Christina S. Moesslacher, Jonathan Woodsmith, Elisabeth Auernig, Andreas Feichtner, Evelyne Jany-Luig, Stefanie Jehle, Josephine M. Worseck, Christian L. Heine, Eduard Stefan, Ulrich Stelzl
NF2 (Neurofibromine 2, merlin) is frequently inactivated in cancer, where its NF2 tumor suppressor functionality is tightly coupled to protein conformation. How NF2 conformation is regulated and how NF2 conformation influences tumor suppressor activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af409b006bfb78ec24da39043fee8777
https://doi.org/10.1101/2022.12.11.519953
https://doi.org/10.1101/2022.12.11.519953
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies
Autor:
Eduard Stefan, Omar Torres-Quesada, Egon Ogris, Johanna E. Mayrhofer, Philipp Tschaikner, Andreas Feichtner, Florian Enzler, Andrea Raffeiner, Jakob Troppmair, Markus Hartl, Rainer Schneider, Roland G. Huber, Ruth Röck, Jakob Fleischmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The pharmaceutical targeting of mutated BRAF has shown promising clinical outcomes in patients with melanoma. However, more than 300 reported BRAF patient mutations and the occurrence of a kinase-drug resistance mechanism hamper patient-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd40c2c1fcc0d48064d424aa4bada7f
https://doi.org/10.1073/pnas.2012150117
https://doi.org/10.1073/pnas.2012150117
Resistance to pharmacological treatments is a major public health challenge. Here we report Resistor—a novel structure- and sequence-based algorithm for drug design providing prospective prediction of resistance mutations. Resistor computes the Par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e99766e9f325937cbd7dfbe2117a16b2
https://doi.org/10.1101/2022.01.18.476733
https://doi.org/10.1101/2022.01.18.476733
Publikováno v:
Cell Systems. 13:830-843.e3
Resistance to pharmacological treatments is a major public health challenge. Here, we introduce Resistor-a structure- and sequence-based algorithm that prospectively predicts resistance mutations for drug design. Resistor computes the Pareto frontier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ceb6a48f2f272b519c292179817be1
https://doi.org/10.1016/j.cels.2022.09.003
https://doi.org/10.1016/j.cels.2022.09.003
Autor:
Andreas Feichtner, Natarajan Kannan, Gema Lordén, Eduard Stefan, Jason C. Del Rio, Eileen J. Kennedy, Charles C. King, David Gonzalez, Wayland Yeung, Ju Chen, Alexandr P. Kornev, Julius Bogomolovas, Jacob M. Wozniak, Timothy R. Baffi, Susan S. Taylor, Christine M. Gould, Ameya J. Limaye, Alexandra C. Newton
Publikováno v:
Sci Signal
The kinase complex mTORC2 is widely accepted as controlling phosphorylation of the hydrophobic motif, a key regulatory switch in the C-terminal tail of protein kinase C (PKC), Akt, and other AGC kinases. Yet the biochemical mechanism by which it cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9d5e5c6ed05edd689fb103fc9eb1e8
https://doi.org/10.1126/scisignal.abe4509
https://doi.org/10.1126/scisignal.abe4509