Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andreas, Eleutheriades"'
Autor:
Andrew Tsotinis, Stavroula Georgakopoulou, Stefanos Riganas, Jean-François Mirjolet, Maria Theodoropoulou, Margarita Prassa, Vassilios I. Moutsos, Andreas Eleutheriades, Guillaume Serin, Alexandre Vamvakides, Humaira Khan, Angeliki Zaniou, Athanasios Mantelas, Ioannis Papanastasiou, George B. Foscolos, Kostas Dimas, Stavroula Pondiki, Vassilios N. Kourafalos
Publikováno v:
Journal of Medicinal Chemistry. 55:10241-10261
The synthesis of the adamantane phenylalkylamines 2a-d, 3a-c, and 4a-e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ(1), σ(2), and sodium channel binding affi
Autor:
Andrew Tsotinis, Margarita Prassa, Guillaume Serin, Ioannis Papanastasiou, Humaira Khan, Stavroula Georgakopoulou, Vassilios I. Moutsos, Jean-Jacques Bourguignon, Jean-François Mirjolet, Vassilios N. Kourafalos, Angeliki Zaniou, Alexandre Vamvakides, Stavroula Pondiki, Stefanos Riganas, Andreas Eleutheriades, George B. Foscolos, Kostas Dimas, Maria Theodoropoulou
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:3323-3331
The synthesis of N-{4-[a-(1-adamantyl)benzyl]phenyl}piperazines 2a-e is described. The in vitro antiproliferative activity of most compounds against main cancer cell lines is significant. The σ(1), σ(2)-receptors and sodium channels binding affinit
Autor:
Stefanos, Riganas, Ioannis, Papanastasiou, George B, Foscolos, Andrew, Tsotinis, Jean-Jacques, Bourguignon, Guillaume, Serin, Jean-François, Mirjolet, Kostas, Dimas, Vassilios N, Kourafalos, Andreas, Eleutheriades, Vassilios I, Moutsos, Humaira, Khan, Stavroula, Georgakopoulou, Angeliki, Zaniou, Margarita, Prassa, Maria, Theodoropoulou, Stavroula, Pondiki, Alexandre, Vamvakides
Publikováno v:
Bioorganicmedicinal chemistry. 20(10)
The synthesis of N-{4-[a-(1-adamantyl)benzyl]phenyl}piperazines 2a-e is described. The in vitro antiproliferative activity of most compounds against main cancer cell lines is significant. The σ(1), σ(2)-receptors and sodium channels binding affinit
Autor:
Andreas Eleutheriades, Vassilios N. Kourafalos, Athanasios Mantelas, Ioannis Papanastasiou, Alexandre Vamvakides, Stavroula Pondiki, Stavroula Georgakopoulou, Stefanos Riganas, Vassilios I. Moutsos, Kostas Dimas, George B. Foscolos, Maria Theodoropoulou, Prassa Margarita, Angeliki Zaniou, Andrew Tsotinis, Humaira Khan
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 8(4)
The synthesis of 4-(1-adamantyl)-4,4-diarylbutylamines 1, 5-(1-adamantyl)-5,5-diarylpentylamines 2 and 6-(1-adamantyl)-6,6-diarylhexylamines 3 is described and the σ1, σ2-receptors and sodium channels binding affinity of compounds 1 were investigat
Autor:
Andrew Tsotinis, Margarita Vlachou, Andreas Eleutheriades, Effie Prinea, Darren Ebreo, Muy-Teck The, David Sugden
Publikováno v:
ChemInform. 33
The potency of new indolic N1-phenethyl substituted melatoninergic ligands with and without methyl groups in the a and b position of the alkanamidoethyl side chain was examined using the pigment aggregation response in a clonal line of Xenopus laevis
Publikováno v:
ChemInform. 39
While attempting to prepare 2,5-dithiacyclopentyl derivatives from N-acyl 5-fluoroindole by reaction with 1,2-ethanedithiol we discovered that, instead of the expected product, annelation occurred to give a tricyclic compound containing a 3,6-dithiaa
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 3(6)
The synthesis of a series of new N-OMe fluoro-indoles with melatoninergic activity in the Xenopus melanophore assay is described. All of the 4-F substituted compounds, 22a-e and 25a,b, were antagonists on the clonal Xenopus melanophore line. Converse
Publikováno v:
Current drug discovery technologies. 4(3)
A series of new C-3 and N1-substituted 4-fluorotryptamides have been prepared and tested for their ability to activate pigment granule aggregation in Xenopus laevis melanophores and bind to the recombinant human MT(1) and MT(2) melatonin receptor sub
Publikováno v:
The Journal of organic chemistry. 72(23)
While attempting to prepare 2,5-dithiacyclopentyl derivatives from N-acyl 5-fluoroindole by reaction with 1,2-ethanedithiol we discovered that, instead of the expected product, annelation occurred to give a tricyclic compound containing a 3,6-dithiaa
Publikováno v:
European journal of medicinal chemistry. 42(7)
A series of new 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-alkanamides, with and without alkyl and cycloalkyl moieties in the beta-position of the alkanamido side chain, have been prepared and tested for their ability to activate pigment granule aggr